İntrauterin İnseminasyon Sikluslarında başarıyı etkileyen faktörler; tek merkezin iki yıllık deneyimi

Öz

Amaç: Bu çalışmanın amacı; ovulatuar disfonksiyonu veya açıklanamayan infertilitesi olan hastalarda, klomifen sitrat ve gonadotropinler ile yapılan ovulasyon indüksiyonu ve intrauterin inseminasyon sikluslarının başarı oranlarını değerlendirmek ve başarıyı etkileyen faktörleri incelemektir. Gereç ve Yöntemler: Haziran 2017 ve Ekim 2019 yılları arasında ovulatuar disfonksiyon veya açıklanamayan infertilite tanısı konan 152 infertil çiftte yapılan 223 intrauterin inseminasyon siklusu kayıtları retrospektif olarak tarandı. Sonuç: Toplamda 33 pozitif gebelik test sonucu elde edildi ve gebelik başarı oranımız %14,8’di. Gonadotropin IUI sikluslarında gebelik başarı oranı %16,6 ve klomifen sitrat IUI sikluslarında gebelik başarı oranı %9,3’dü. Ovulatuar disfonksiyonu ve açıklanamayan infertilitesi olan infertil populasyonda sigara içmenin IUI başarısı üzerine olumsuz etkisi saptanırken (p=0,012); kadın yaşı, BMI, infertilite süresi, bazal FSH, LH, östradiol düzeyleri ve trigger günü endometiral kalınlık ile IUI başarısı arasında bir ilişki saptanmadı.

Anahtar Kelimeler

• Ovulasyon indüksiyonu
• intrauterin inseminasyon
• prognostik faktörler
• gebelik oranı

Factors affecting success in intrauterine insemination cycles; 2-year single center experience

Öz

Abstract Objective: The aim of this study is to evaluate the success rates of intrauterine insemination cycles due to ovulation induction with clomiphene citrate and gonadotropins, and to identify factors associated with successful outcomes in women with unexplained infertility and ovulatory dysfunction. Material and Methods: Between June 2017 and October 2019, 223 intrauterine insemination cycle records were scanned retrospectively in 152 infertile couples diagnosed with ovulatory dysfunction or unexplained infertility. Result: A total of 33 positive pregnancy test results were obtained, which had shown a pregnancy success rate of 14.8%. Pregnancy success rate in Gonadotropin IUI (Intrauterine Insemination) cycles was found as 16.6% and pregnancy success rate in CC (Clomiphene Citrate) IUI cycles was found as 9.3%. While it has been detected that smoking has had a negative effect on IUI success rate for the infertile population with ovulatory dysfunction and unexplained infertility (p=0.012); factors such as female age, BMI (Body mass index), infertility span, basal FSH (Follicle Stimulating Hormone), basal LH (Luteinizing Hormone), basal estradiol levels and trigger-day endometrial thickness were found to have no correlation with IUI success rate at all.

Anahtar Kelimeler

• Ovulation induction
• intrauterine insemination
• prognostic factors
• pregnancy rate

Kaynakça

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