Clinical and Laboratory Results of Newborn Babies Born from Pregnant Women Infected with COVID-19

Öz

Aim: Covidien-19, which is a worldwide pandemic virus, has caused numerous casualties. Studies are carried out on newborn babies of pregnant women infected with the new type of coronavirus, and studies are in progress investigating vertical transmission. In our study, we plan to evaluate the clinical and laboratory results of newborn babies born from pregnant women infected with COVID-19 y. Materials and Method: This retrospective cohort study was carried out at Medical Sciences University Konya Teaching and Research Hospital, between April 2020 and August 2020. Newborn babies born from pregnant women, who were found to have a new type of coronavirus (SARS-CoV-2) infection with reverse transcriptase-polymerase chain reaction (RT-PCR) at the time of delivery, were included in the study. Complete blood count, biochemical profile, acute phase reactants, D-Dimer and ferritin values of pregnant women while they were infected with the SARS-CoV-2 were recorded. Complete blood count, biochemical values and acute phase reactants of newborn babies as well as two COVID-RT-PCR test results, conducted 24-hours apart, were noted. Fourteen pregnant women and their newborns, who satisfy the requirements, were included in the study. Results: Fourteen mothers and babies were included in the study. Both COVID-RT-PCR results of all newborn babies came back negative. Lymphocyte percentage and values of newborns were statistically higher compared to their mothers (p<0.05). At the time of hospitalization, the most common symptom was respiratory distress with 7 (50%) patients. Looking at the diagnosis at the time of hospitalizations, 6 (42.9%) patients had transient tachypnea of neonates, 1 (7.1%) had early onset neonatal sepsis and 1 (7.1%) had hypoxic ischemic encephalopathy. Six healthy babies were hospitalized in the NICU due to their mothers’ condition. In addition, the patient, who was followed up with a diagnosis of hypoxic ischemic encephalopathy, died due to her primary disease. Conclusion: In our study, we observed the absence of transplacental transmission from pregnant women infected with SARS-CoV-2 to their newborn babies.

Anahtar Kelimeler

• COVID-19
• newborn
• pregnant women
• vertical
• transplacental

Covid 19 Testi Pozitif iken Doğum Yapan 14 Gebenin Bebeklerinin Klinik ve Laboratuvar Sonuçları

Öz

Amaç: Dünya çapında bir pandemiye neden olan COVID-19 virüsü çok sayıda can kaybına neden olmuştur. Yeni tip koronavirüs ile enfekte olan gebelerin yenidoğan bebekleri ile ilgili çalışmalar yapılmakta olup vertikal geçiş açısından çalışmalar devam etmektedir. Biz de çalışmamızda COVID-19 ile enfekte olan gebelerden doğan yenidoğan bebeklerin klinik ve laboratuvar sonuçlarını değerlendirmeyi planladık. Gereçler ve Yöntem: Bu retrospektif çalışma, Sağlık Bilimleri Üniversitesi Konya Eğitim ve Araştırma Hastanesi Yenidoğan Yoğun Bakım Ünitesinde Nisan 2020- Ağustos 2020 tarihleri arasında yapıldı. Doğum yaptığı esnada revers transkriptaz-polimeraz zincir reaksiyonu (RT-PCR) ile yeni tip koronavirüs (SARS-CoV-2) enfeksiyonu saptanan gebelerden doğan yenidoğan bebeklerin çalışmaya dahil edilmesi planlandı. Gebelerin SARS-CoV-2 ile enfekte olduğu dönemde bakılan tam kan sayımı, biyokimyasal değerleri, akut faz reaktanları, D-Dimer ve ferritin değerleri kaydedildi. Yenidoğan bebeklerde ise tam kan sayımı, biyokimyasal değerleri ve akut faz reaktanları değerlendirilmeye alındı. Yenidoğan bebeklerin hepsinde 24 saat ile bakılan 2 tane COVID RT-PCR sonuçları not edildi. Gereken verilerine ulaşılan 14 gebe ve yenidoğan bebeği çalışmaya dahil edildi. Bulgular: Yenidoğan bebeklerin hepsinde 24 saat ara ile bakılan 2 tane COVID RT-PCR sonucu negatif olarak geldi. Yenidoğanların lenfosit yüzdesi ve değeri annelerine göre istatistiksel olarak yüksek saptandı (p<0,05). Yatış anındaki şikayetler değerlendirildiğinde; en sık şikayet 7 hastada (%50,0) solunum sıkıntısı idi. Yatış tanılarına bakıldığında; 6 hasta (%42,9) sağlıklı bebek, 6 hasta(%42,9) yenidoğan geçici takipnesi, 1 hasta (%7,1) erken neonatal sepsis ve 1 hasta (%7,1) hipoksik iskemik ensefalopati tanısı ile takip edildi. Ayrıca hipoksik iskemik ensefalopati tanısı ile takip edilen hasta primer hastalığı nedeni ile kaybedildi. Sonuç: Biz çalışmamızda SARS-CoV-2 ile enfekte olan gebeden yenidoğan bebeğe transplasental geçişin olmadığını destekler sonuçlar elde ettik.

Anahtar Kelimeler

• COVID-19
• yenidoğan
• gebe
• transplasental
• vertikal

Kaynakça

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