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BRCA Gene Mutations And Hereditary Breast And Ovarian Cancer Syndrome From The Perspective Of Ovarian Cancer

Yıl 2018, Cilt: 15 Sayı: 3, 135 - 144, 01.07.2018

İlker Selçuk Şule Özel Tayfun Güngör Yaprak Engin-üstün

Öz

Since ovarian cancer has the highest mortality rates among all the gynecological cancers, there is a tremendous effort to decrease this occasion by surveillance and prophylactic interventions. Ovarian cancer is mostly sporadic, however some people have an increased risk than the overall population due to hereditary and genetic predispositions. BRCA gene mutations are most commonly detected pathology in whom have a hereditary ovarian cancer risk. Genetic counseling, surveillance and prophylactic surgeries with regard to BRCA gene mutations should be applied by an experienced team in a multi-disciplinary approach.

Anahtar Kelimeler

BRCA ovarian cancer screening follow-up

Kaynakça

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Over Kanseri Perspektifinde BRCA Gen Mutasyonları Ve Herediter Meme ve Over Kanser Sendromu

Yıl 2018, Cilt: 15 Sayı: 3, 135 - 144, 01.07.2018

İlker Selçuk Şule Özel Tayfun Güngör Yaprak Engin-üstün

Öz

Over kanseri en çok ölümle sonuçlanan jinekolojik kanser olup, tarama çalışmalarıyla beraber önleyici girişimler ile ölüm oranlarının azaltılması için çok fazla çalışma vardır. Hastalık çoğunlukla sporadik gelişse de, ailesel faktörler ve genetik kökenli yatkınlık bazı bireyleri toplumsal oranlara göre artmış bir risk kuşağına sokmaktadır. Ailesel over kanseri yatkınlığı olan kişilerde en sık BRCA gen mutasyonları tespit edilmiş olup, BRCA gen mutasyonu taşıyan kişilere verilecek olan hizmetler; genetik danışmanlık, tarama ve koruyucu girişimler belli bir perspektif içerisinde tecrübeli bir ekip tarafından multi-disipliner bir yapıda yapılmalıdır.

Anahtar Kelimeler

BRCA over kanseri tarama takip

Kaynakça

  • Committee on Gynecologic Practice SoGO. Committee Opinion No. 716: The Role of the Obstetrician-Gynecologist in the Early Detection of Epithelial Ovarian Cancer in Women at Average Risk. Obstet Gynecol. 2017;130(3):e146-e9.
  • Kurman RJ, Shih Ie M. The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol. 2010;34(3):433-43.
  • Lancaster JM, Powell CB, Chen LM, Richardson DL, Committee SGO- CP. Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions. Gynecol Oncol. 2015;136(1):3-7.
  • Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G, et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol. 2014;15(8):852-61.
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  • Rebbeck TR, Lynch HT, Neuhausen SL, Narod SA, Van’t Veer L, Garber JE, et al. Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. N Engl J Med. 2002;346(21):1616-22.
  • Domchek SM, Friebel TM, Neuhausen SL, Wagner T, Evans G, Isaacs C, et al. Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study. Lancet Oncol. 2006;7(3):223-9.
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  • S. M. Domchek TF, S. L. Neuhausen, H. T. Lynch, C. F. Singer, R. A. Eeles, C. Isaacs, N. M. Tung, P. A. Ganz, F. J. Couch, J. N. Weitzel, O. I. Olopade, W. S. Rubinstein, G. E. Tomlinson, G. C. Pichert, M. B. Daly, E. T. Matloff, D. G. Evans, J. E. Garber, T. R. Rebbeck, PROSE Consortium. Is hormone replacement therapy (HRT) following risk-reducing salpin- go-oophorectomy (RRSO) in BRCA1 (B1)- and BRCA2 (B2)-mutation carriers associated with an increased risk of breast cancer? J Clin Oncol 29: 2011 (suppl; abstr 1501). 2011.
Toplam 106 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Collection
Yazarlar

İlker Selçuk Bu kişi benim

Şule Özel Bu kişi benim

Tayfun Güngör Bu kişi benim

Yaprak Engin-üstün Bu kişi benim

Yayımlanma Tarihi 1 Temmuz 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 15 Sayı: 3

Kaynak Göster

Vancouver Selçuk İ, Özel Ş, Güngör T, Engin-üstün Y. Over Kanseri Perspektifinde BRCA Gen Mutasyonları Ve Herediter Meme ve Over Kanser Sendromu. JGON. 2018;15(3):135-44.