PREMATURE OVARIAN INSUFFICIENCY

Yıl 2012, Cilt: 9 Sayı: 36, 1498 - 1501, 01.10.2012

Özlem Gün Eryılmaz Saynur Yılmaz Melike Doğanay Gülnur Özakşit

Öz

Premature Ovarian Insufficiency POF describes the diminished ovarian functions before the age 40. Related with the clinics of POF, menopausal symptoms, sub fertility, long term cardiovascular dysfunctions, osteoporosis and psychological problems are mentioned. Among the etiological factors most of them are idiopathic, and the less frequently pronounced items consists of oopherectomy, chemotherapy or radiotherapy, genetic factors, autoimmune adrenal and throid problems and FSH reseptor defects. Related with the infertility treatments no intervention has been found to improve conception rates. IVF with donor oocytes is the only treatment option.

Anahtar Kelimeler

Premature ovarian insufficiency, Infertility

PREMATUR OVER YETERSiZLiGi

Öz

Prematiir over yetersizligi POY , 40 yaşımdan once, overlerin fonksiyon kapasitesindeki azalmay1 ifade eder. POY ile menapozal semptomlar başlar, subfertilite, uzun donemde ortaya çıkabilecek kardiovaskiiler problemler, osteoporoz riski ve hatta psikolojik sıkıntilar oluşabilecek komplikasyonlar arasmdad1r. Etiyolojik faktörler içinde çogu idiopatik olmakla birlikte, ooferektomi, kemoterapi, radyoterapi, genetik bozukluklar, otoimmiine adrenal ve tiroid hastahklan ve FSH reseptör defektleri sayilabilir. Tedavinin temelinde estrojen ve progesteron içeren kombine preparatlarla hormon replasmam vardır. Spontan gebelik çok az gorülür, infertilite tedavilerinin başarısı yok denecek kadar azdır, çocuk sahibi olma ancak ülkemizde yasal olmayan donor oositli IVF ile mümkündür.

Anahtar Kelimeler

Prematlir over yetersizligi, nfertilite

Kaynakça

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