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THE EFFECTS OF MATERNAL VITAMIN LEVELS ON INFANT BIRTH WEIGHT

Yıl 2020, Cilt 17, Sayı 4, 569 - 573, 31.12.2020
https://doi.org/10.38136/jgon.742332

Öz

Aim: Malnutrition and vitamin deficiency during pregnancy result in low birth weight, neural tube defects, placenta and fetus anomalies and preterm delivery. The aim of this study is to investigate the effects of maternal vitamin D, B12, folate and homocysteine levels on infant birth weight. Materials and Method: The retrospective study population comprised 76 pregnancies delivered at Goztepe Training and Research Hospital affiliated to Istanbul Medeniyet University between January 2017 and December 219. Womens were grouped as normal and low according to the vitamin D, B12, folate and homocysteine levels recorded at 37-42 weeks of gestation. Maternal serum vitamin D, B12, folate and homocysteine levels were defined as low <20 ng/mL, <200 pg/mL<2.5 ng/mL, and <5 µM/L, respectively. It was investigated whether there was a significant difference between infant birth weight in both groups and the effects of mother serum vitamin levels on the infant birth weight. Results: The mean maternal age and gestational age were 24.7±4.5 and 39.6±1 week, respectively. The mean infant birth weight was 3320±345 gram. There was no relationship between maternal vitamin D, B12 and homocysteine levels during pregnancy and neonatal birth weight (p >0.05). When confounding variables were adjusted, a positive correlation was found between maternal folate level and infant birth weight (p <0.05). Conclusion: According to the results of this study, it can be considered that the level of maternal folate plays an important role in determining the birth weight of the infants.

Kaynakça

  • 1. Uzdil, Z and Özenoğlu, A. Gebelikte çeşitli besin öğeleri tüketiminin bebek sağlığı üzerine etkileri. Balıkesir Sağlık Bilimleri Dergisi 2015; 4(2): 117-121.
  • 2. McArdle HJ and Ashworth CJ. Micronutrients in fetal growth and development. Br Med Bull. 1999;55: 499-510.
  • 3. Kozuki N, Katz J, Lee AC, Vogel J, Silveira M, Short A. Maternal stature increases risk of small for gestational age and preterm births in low and middle-income countries: Individual participant data meta-analysis and population attributable fraction. J. Nutr. 2015; 145: 2542–2550.
  • 4. Grisaru-Granovsky S, Reichman B, Lerner-Geva L, Boyko V, Hammerman C, Samueloff A et al. Israel Neonatal Network. Mortality and morbidity in preterm small-for- gestational-age infants: A population-based study. Am. J. Obstet. Gynecol. 2012; 206: 150.e1–150.e7.
  • 5. World Health Organization (2019). Too many babies are born too small. World Health Organization. https://www.who.int/news-room/detail/16-05-2019-too-many-babies-are-borntoo- small.
  • 6. Unal M and Gonulalan G. Serum vitamin D level is related to disease severity in pediatric alopecia areata, J Cosmet Dermatol. 2018;17(1):101-104.
  • 7. Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med 2013; 368:149.
  • 8. Dorum BA, Şilfeler I, Dorum S, Şilfeler DB, Canbak Y, Kurnaz H. Anne vitamin B12 ve folat düzeylerinin bebek doğum ağırlığı üzerine etkisi. Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi 2009: 121-129.
  • 9. Matchar DB, McCrory DC, Millington DS, R.Feussner J. Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. Am J Med Sci 1994; 308:276
  • 10. Black RE. Micronutrients in pregnancy. British Journal of Nutrition 2001; 85: 193–7.
  • 11. Fekete, K, Berti, C, Trovato, M, Lohner S, Dullemeijer C, Souverein O et al. Effect of folate intake on health outcomes in pregnancy: a sys-tematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutrition Journal. 2012; 11(75): 1-8.
  • 12. Lucock M, Yates Z, Glanville T, Szimonetta Lohner, Carla Dullemeijer, Olga W et al. A critical role for B-vitamin nutrition in human development and evolutionary biology. Nutr Rev. 2003; 23: 1463–1475. 13. van der Molen EF, Verbruggen B, Nokalova I, Eskes KAB, Monnens LAH, Blom HJ. Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy. Br J Obstet Gynaecol. 2000; 107: 785–791
  • 14. Baschat AA and Hecher K. Fetal growth restriction due to placental disease. Semin Perinatol. 2004;28: 67–80.
  • 15. Wang S, Ge X, Zhu B, Xuan Y, Huang K, Rutayisire E et al. Maternal continuing folic acid supplementation after the first trimester of pregnancy ıncreased the risk of large-for-gestational-age birth: a population-based birth cohort study. Nutrient. 2016; 8(8): 1-11.
  • 16. World Health Organization Guideline: Daily iron and folic acid supplementation in pregnant women. World Health Organization 2012; 1-27.
  • 17. Ersoy G, Rakıcıoğlu N, Karabudak E, et al. Yaşam sürecinde beslenmenin önemi ve enerji dengesi. Türkiye beslenme rehberi. Ankara, Turkey: T.C. Sağlık Bakanlığı, No: 1031, 2015:102–5.
  • 18. Erbay E, Mersin S, İ brahimoğlu Ö. D Vitamini ve vücut sistemleri üzerine etkisi. Health Care Acad J 2019;6: Issue 3
  • 19. Alper Gürz, A, İğde A, Arttıran FA, Dikici M. Vitamininin fetal ve maternal etkileri. Konuralp Tıp Dergisi, 201; 7(1): 69-75.
  • 20. Finkelstein JL, Layden AJ, Stover PJ. Vitamin B-12 and perinatal health. Adv Nutr 2015; 6: 1–12.
  • 21. Guerra-Shinohara EM, Paiva AA, Rondo PH, Yamasaki Carolina K, Terzi A, D'Almeida V. Relationship between total homocysteine and folate levels in pregnant women and their newborn babies accord ing to maternal serum levels of vitamin B12. BJOG 2002; 109(7): 784-91.
  • 22. A Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes of Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic acid, Biotin and Choline. Washington, D.C.: National Academy Pres; 2000. p. 306-56.
  • 23. Wei SQ, Qi HP, Luo ZC, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: A systematic review and meta-analysis. The Journal of Maternal-fetal and Neonatal Medicine. 2013; 26: 889–899.
  • 24. Chandyo RK, Ulak M, Kvestad I, Shrestha M, Ranjitkar S, Basnet S et al. The effects of vitamin B12 supplementation in pregnancy and postpartum on growth and neurodevelopment in early childhood: Study Protocol for a Randomized Placebo Controlled Trial. BMJ Open. 2017; 29; 7(8): e016434.
  • 25. Ubeda N, Reyes L, González-Medina A, Alonso-Aperte E, Varela-Moreiras G. Physiologic changes in homocysteine metabolism in pregnancy: a longitudinal study in Spain. Nutrition, 2011, 27.9: 925-93
  • 26. De Falco M, Pollio F, Scaramellino M, Pontillo M, Lieto AD. Homocysteinaemia during pregnancy and placental disease. Clin Exp Obstet Gynecol. 2000;27(3-4):188-90.

ANNE VİTAMİN DÜZEYLERİNİN BEBEK DOĞUM AĞIRLIĞI ÜZERİNE ETKİSİ

Yıl 2020, Cilt 17, Sayı 4, 569 - 573, 31.12.2020
https://doi.org/10.38136/jgon.742332

Öz

Aim: Malnutrition and vitamin deficiency during pregnancy result in low birth weight, neural tube defects, placenta and fetus anomalies and preterm delivery. The aim of this study is to investigate the effects of maternal vitamin D, B12, folate and homocysteine levels on infant birth weight. Materials and Method: The retrospective study population comprised 76 pregnancies delivered at Goztepe Training and Research Hospital affiliated to Istanbul Medeniyet University between January 2017 and December 2019. Womens were grouped as normal and low according to the vitamin D, B12, folate and homocysteine levels recorded at 37-42 weeks of gestation. Maternal serum vitamin D, B12, folate and homocysteine levels were defined as low <20 ng/mL, <200 pg/mL<2.5 ng/mL, and <5 µM/L, respectively. It was investigated whether there was a significant difference between infant birth weight in both groups and the effects of mother serum vitamin levels on the infant birth weight. Results: The mean maternal age and gestational age were 24.7±4.5 and 39.6±1 week, respectively. The mean infant birth weight was 3320±345 gram. There was no relationship between maternal vitamin D, B12 and homocysteine levels during pregnancy and neonatal birth weight (p >0.05). When confounding variables were adjusted, a positive correlation was found between maternal folate level and infant birth weight (p <0.05). Conclusion: According to the results of this study, it can be considered that the level of maternal folate plays an important role in determining the birth weight of the infants.

Kaynakça

  • 1. Uzdil, Z and Özenoğlu, A. Gebelikte çeşitli besin öğeleri tüketiminin bebek sağlığı üzerine etkileri. Balıkesir Sağlık Bilimleri Dergisi 2015; 4(2): 117-121.
  • 2. McArdle HJ and Ashworth CJ. Micronutrients in fetal growth and development. Br Med Bull. 1999;55: 499-510.
  • 3. Kozuki N, Katz J, Lee AC, Vogel J, Silveira M, Short A. Maternal stature increases risk of small for gestational age and preterm births in low and middle-income countries: Individual participant data meta-analysis and population attributable fraction. J. Nutr. 2015; 145: 2542–2550.
  • 4. Grisaru-Granovsky S, Reichman B, Lerner-Geva L, Boyko V, Hammerman C, Samueloff A et al. Israel Neonatal Network. Mortality and morbidity in preterm small-for- gestational-age infants: A population-based study. Am. J. Obstet. Gynecol. 2012; 206: 150.e1–150.e7.
  • 5. World Health Organization (2019). Too many babies are born too small. World Health Organization. https://www.who.int/news-room/detail/16-05-2019-too-many-babies-are-borntoo- small.
  • 6. Unal M and Gonulalan G. Serum vitamin D level is related to disease severity in pediatric alopecia areata, J Cosmet Dermatol. 2018;17(1):101-104.
  • 7. Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med 2013; 368:149.
  • 8. Dorum BA, Şilfeler I, Dorum S, Şilfeler DB, Canbak Y, Kurnaz H. Anne vitamin B12 ve folat düzeylerinin bebek doğum ağırlığı üzerine etkisi. Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi 2009: 121-129.
  • 9. Matchar DB, McCrory DC, Millington DS, R.Feussner J. Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. Am J Med Sci 1994; 308:276
  • 10. Black RE. Micronutrients in pregnancy. British Journal of Nutrition 2001; 85: 193–7.
  • 11. Fekete, K, Berti, C, Trovato, M, Lohner S, Dullemeijer C, Souverein O et al. Effect of folate intake on health outcomes in pregnancy: a sys-tematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutrition Journal. 2012; 11(75): 1-8.
  • 12. Lucock M, Yates Z, Glanville T, Szimonetta Lohner, Carla Dullemeijer, Olga W et al. A critical role for B-vitamin nutrition in human development and evolutionary biology. Nutr Rev. 2003; 23: 1463–1475. 13. van der Molen EF, Verbruggen B, Nokalova I, Eskes KAB, Monnens LAH, Blom HJ. Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy. Br J Obstet Gynaecol. 2000; 107: 785–791
  • 14. Baschat AA and Hecher K. Fetal growth restriction due to placental disease. Semin Perinatol. 2004;28: 67–80.
  • 15. Wang S, Ge X, Zhu B, Xuan Y, Huang K, Rutayisire E et al. Maternal continuing folic acid supplementation after the first trimester of pregnancy ıncreased the risk of large-for-gestational-age birth: a population-based birth cohort study. Nutrient. 2016; 8(8): 1-11.
  • 16. World Health Organization Guideline: Daily iron and folic acid supplementation in pregnant women. World Health Organization 2012; 1-27.
  • 17. Ersoy G, Rakıcıoğlu N, Karabudak E, et al. Yaşam sürecinde beslenmenin önemi ve enerji dengesi. Türkiye beslenme rehberi. Ankara, Turkey: T.C. Sağlık Bakanlığı, No: 1031, 2015:102–5.
  • 18. Erbay E, Mersin S, İ brahimoğlu Ö. D Vitamini ve vücut sistemleri üzerine etkisi. Health Care Acad J 2019;6: Issue 3
  • 19. Alper Gürz, A, İğde A, Arttıran FA, Dikici M. Vitamininin fetal ve maternal etkileri. Konuralp Tıp Dergisi, 201; 7(1): 69-75.
  • 20. Finkelstein JL, Layden AJ, Stover PJ. Vitamin B-12 and perinatal health. Adv Nutr 2015; 6: 1–12.
  • 21. Guerra-Shinohara EM, Paiva AA, Rondo PH, Yamasaki Carolina K, Terzi A, D'Almeida V. Relationship between total homocysteine and folate levels in pregnant women and their newborn babies accord ing to maternal serum levels of vitamin B12. BJOG 2002; 109(7): 784-91.
  • 22. A Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes of Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic acid, Biotin and Choline. Washington, D.C.: National Academy Pres; 2000. p. 306-56.
  • 23. Wei SQ, Qi HP, Luo ZC, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: A systematic review and meta-analysis. The Journal of Maternal-fetal and Neonatal Medicine. 2013; 26: 889–899.
  • 24. Chandyo RK, Ulak M, Kvestad I, Shrestha M, Ranjitkar S, Basnet S et al. The effects of vitamin B12 supplementation in pregnancy and postpartum on growth and neurodevelopment in early childhood: Study Protocol for a Randomized Placebo Controlled Trial. BMJ Open. 2017; 29; 7(8): e016434.
  • 25. Ubeda N, Reyes L, González-Medina A, Alonso-Aperte E, Varela-Moreiras G. Physiologic changes in homocysteine metabolism in pregnancy: a longitudinal study in Spain. Nutrition, 2011, 27.9: 925-93
  • 26. De Falco M, Pollio F, Scaramellino M, Pontillo M, Lieto AD. Homocysteinaemia during pregnancy and placental disease. Clin Exp Obstet Gynecol. 2000;27(3-4):188-90.

Ayrıntılar

Birincil Dil İngilizce
Konular Kadın Hastalıkları ve Doğum
Bölüm Araştırma Makaleleri
Yazarlar

Meryem HOCAOĞLU (Sorumlu Yazar)
Goztepe Training and Research Hospital, Istanbul Medeniyet University,
0000-0002-1832-9993
Türkiye


Özgül BULUT
Goztepe Training and Research Hospital, Istanbul Medeniyet University,
0000-0001-9939-7375
Türkiye


Taner GÜNAY
Goztepe Training and Research Hospital, Istanbul Medeniyet University,
0000-0002-3985-0702
Türkiye


Abdulkadir TURGUT
Goztepe Training and Research Hospital, Istanbul Medeniyet University,
0000-0002-3156-2116
Türkiye


Fahri OVALI
Goztepe Training and Research Hospital, Istanbul Medeniyet University,
0000-0002-9717-313X
Türkiye

Destekleyen Kurum Yok
Proje Numarası Yok
Teşekkür Yok
Yayımlanma Tarihi 31 Aralık 2020
Başvuru Tarihi 25 Mayıs 2020
Kabul Tarihi 6 Ağustos 2020
Yayınlandığı Sayı Yıl 2020, Cilt 17, Sayı 4

Kaynak Göster

Vancouver Hocaoğlu M. , Bulut Ö. , Günay T. , Turgut A. , Ovalı F. THE EFFECTS OF MATERNAL VITAMIN LEVELS ON INFANT BIRTH WEIGHT. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2020; 17(4): 569-573.