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Preeklampsi ve HELLP Sendromlu Olgularda Nötrofil-Lenfosit Oranı (NLO), Platelet-Lenfosit Oranı (PLO) ve Ortalama Platelet Hacminin (OPH) Karşılaştırılması

Yıl 2021, Cilt 18, Sayı 4, 1083 - 1088, 31.12.2021
https://doi.org/10.38136/jgon.985290

Öz

Amaç: Bu çalışmada hem HELLP sendromlu hem de preeklampsili hastaların NLO ve PLO değerleri normal sağlıklı kontrol grubu ile karşılaştırıldı. Metod: Bu çalışma, 2012-2020 yılları arasında Mersin Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum servisine yatan 50 HELLP sendromu, 110 şiddetli Preeklampsi (PE) ve 61 kontrol hastasının dosyaları taranarak retrospektif olarak yapıldı. Çalışmada HELLP sendromu ve preeklampsi hastaları, sağlıklı kontrol grubu ile karşılaştırıldı. Ek hastalığı olan hastalar çalışma dışı bırakıldı. Hasta gruplarının venöz kan hemogram parametreleri ve doğum sırasında alınan biyokimyasal değerleri kaydedildi. Hastaların yaşı, gebelik haftası, karaciğer fonksiyon testleri, böbrek fonksiyon testleri, hemogram parametreleri, NLO ve PLO değerleri ve oluşan komplikasyonlar karşılaştırıldı. Çalışmanın etik onamı alındı (Karar tarihi:28/04/2021; Karar sayısı: 343) Sonuçlar: Çalışmada nötrofil sayısı, HELLP sendromu grubunda, kontrol grubuna göre anlamlı olarak yüksek bulundu (sırası ile 9493 ve 7210 p=0,04). NLO, hem HELLP sendromu hem de PE grubunda, kontrol grubuna göre yüksek bulundu (HELLP sendromu grubunda kontrol grubuna göre anlamlı olarak yüksekti (sırası ile 5,47 ve 3,66, p=0,02)). PLO, hem HELLP sendromu hem de PE grubunda, kontrol grubuna göre düşük bulundu (HELLP sendromu grubunda, kontrol grubuna (sıra ile 72 ve 111,18, p=0,0001) ve PE grubuna göre (sırası ile 72 ve 107,75 p=0,0002) anlamlı olarak düşük bulundu). Platelet sayısında tüm gruplar arasında anlamlı fark vardı (HELLP sendromu grubunda, PE grubuna (sıra ile 139,181 ve 196,222, p=0,0002) ve kontrol grubuna (sıra ile 139,181 ve 222,639, p=0,0001) göre anlamlı olarak düşük bulundu. Ayrıca PE grubunda, kontrol grubuna göre (sırası ile 196,222 ve 222,639 p=0,003) anlamlı olarak düşük bulundu). OPH, HELLP sendromu grubunda kontrol grubuna göre (sıra ile 9,95 ve 11,13, p=0,04) anlamlı olarak düşük bulundu. Sonuç: Çalışmamızda inflamatuar belirteçlerden NLO’nun artışının ve PLO ve OPH’nin azalmasının hem HELLP sendromu tanısında hem de HELLP sendromu ile PE ayrımında kullanılabileceği sonucuna ulaşıldı

Kaynakça

  • 1. American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin No. 222: Gestational Hypertension and Preeclampsia. Obstet Gynecol 2020; 135:e237.
  • 2. T.Y. Wong, H. Groen, M.M. Faas, M.G. van Pampus, Clinical risk factors for gestational hypertensive disorders in pregnant women at high risk for developing preeclampsia, Pregnancy Hypertens. 3 (4) (2013) 248–253.
  • 3. Harmon, A.C., Cornelius, D.C., Amaral, L.M., Faulkner, J.L., Cunningham Jr, M.W., Wallace, K., LaMarca, B., 2016. The role of inflammation in the pathology of preeclampsia. Clin. Sci. (Lond). 130 (6), 409–419.
  • 4. E. Laresgoiti-Servitje, N. Gomez-Lopez, D.M. Olson, An immunological insight into the origins of pre-eclampsia, Hum. Reprod. Update 16 (5) (2010) 510–524.
  • 5. W.W. Zhang, K.J. Liu, G.L. Hu, W.J. Liang, Preoperative platelet/lymphocyte ratio is a superior prognostic factor compared to other systemic inflammatory response markers in ovarian cancer patients, Tumour Biol. 36 (11) (2015) 8831–8837.
  • 6. Canzoneri, B.J.; Lewis, D.F.; Groome, L.; Wang, Y. Increased neutrophil numbers account for leukocytosis in women with preeclampsia. Am. J. Perinatol. 2009, 26, 729–732.
  • 7. Al Sheeha, M.A.; Alaboudi, R.S.; Alghasham, M.A.; Iqbal, J.; Adam, I. Platelet count and platelet indices in women with preeclampsia. Vasc. Health Risk Manag. 2016, 12, 477–480.
  • 8. Mannaerts, D.; Heyvaert, S.; de Cordt, C.; Macken, C.; Loos, C.; Jacquemyn, Y. Are neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and/or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia? J. Matern. Fetal Neonatal. Med. 2019, 32, 1412–1419.
  • 9. Serin, S.; Avcı, F.; Ercan, O.; Köstü, B.; Bakacak, M.; Kıran, H. Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia? Pregnancy Hypertens. 2016, 6, 22–25.
  • 10. Cintesun, E.; Incesu Cintesun, F.N.; Ezveci, H.; Akyurek, F.; Celik, C. Systemic inflammatory response markers in preeclampsia. J. Lab. Phys. 2018, 10, 316–319
  • 11. R.K. Kurt, Z. Aras, D.B. Silfeler, C. Kunt, M. Islimye, O. Kosar, Relationship of red cell distribution width with the presence and severity of preeclampsia, Clin.Appl. Thromb. Hemost. 21 (2) (2015) 128–131.
  • 12. A. Karateke, R.K. Kurt, A. Baloglu, Relation of platelet distribution width (PDW) and platelet crit (PCT) to preeclampsia, Ginekol Pol. 86 (5) (2015) 372–375.
  • 13. A. Kirbas, A.O. Ersoy, K. Daglar, T. Dikici, E.H. Biberoglu, O. Kirbas, et al., Prediction of preeclampsia by first trimester combined test and simple complete blood count parameters, J. Clin. Diagn. Res. 9 (11) (2015). QC20-3.
  • 14. H. Abdullahi, A. Osman, D.A. Rayis, G.I. Gasim, A.M. Imam, I. Adam, Red blood cell distribution width is not correlated with preeclampsia among pregnant Sudanese women, Diagn Pathol. 9 (2014) 29.
  • 15. Gezer, C.; Ekin, A.; Ertas, I.E.; Ozeren, M.; Solmaz, U.; Mat, E.; Taner, C.E. High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia. Ginekol. Pol. 2016;87(6):431-5.
  • 16. Agrawal, N.; Yadav, P.; Bishnoi, S.; Fayyaz, S. Can High First Trimester NLR And PLR is Early Predictor for Preeclampsia?: An Experience of Single Tertiary Care Center. Arch. Reprod. Med. Sex. Health 2018, 1, 3–7.
  • 17. Sachan, R.; Lal Patel, M.; Solanki, V.; Sachan, P.; Shyam, R. Diagnostic accuracy of neutrophil to lymphocyte ratio in prediction of nonsevere preeclampsia and severe preeclampsia. J. Curr. Res. Sci. Med. 2017.
  • 18. Ferrazzi, E.; Stampalija, T.; Monasta, L.; Di Martino, D.; Vonck, S.; Gyselaers,W. Maternal hemodynamics: A method to classify hypertensive disorders of pregnancy. Am. J. Obstet. Gynecol. 2018. Jan:218(1):124.e1-124.e11
  • 19. Stone JH. HELLP syndrome: hemolysis, elevated liver enzymes, and low platelets. JAMA1998; 280:559.
  • 20. Kinay, T.; Kucuk, C.; Kayikcioglu, F.; Karakaya, J. Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at <34 and _34 Weeks’ Gestation. Balkan Med. J. 2015, 32.
  • 21. Vigil-de Gracia, P.E.; Tenorio-Maranon, F.R.; Cejudo-Carranza, E.; Helguera-Martinez, A.; Garcia-Caceres, E. [Di_erence between preeclampsia, HELLP syndrome and eclampsia, maternal evaluation]. Ginecol. Obstet. Mex. 1996, 64, 377–382.
  • 22. Sibai BM, Taslimi MM, el-Nazer A, et al. Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsiaeclampsia. Am J Obstet Gynecol 1986; 155:501
  • 23. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am J Obstet Gynecol 1990; 162:311.
  • 24. Cornelius, D.C. Preeclampsia: From Inflammation to Immunoregulation. Clin. Med. Insights Blood Disord. 2018, 11, 1179545X17752325
  • 25. I. Ann-Charlotte, Inflammatory mechanisms in preeclampsia, Pregnancy Hypertens. 3 (2) (2013) 58.
  • 26. I. Sari, M. Sunbul, C. Mammadov, E. Durmus, M. Bozbay, T. Kivrak, et al.,Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography, Kardiol. Pol. 73 (12) (2015) 1310–1316.
  • 27. H.Q. Ying, Q.W. Deng, B.S. He, Y.Q. Pan, F. Wang, H.L. Sun, et al., The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients, Med. Oncol. 31 (12) (2014) 305.
  • 28. K.D. Seckin, M.F. Karsli, B. Yucel, M. Bestel, D. Yildirim, E. Canaz, et al., The utility of tumor markers and neutrophil lymphocyte ratio in patients with an intraoperative diagnosis of mucinous borderline ovarian tumor, Eur. J. Obstet. Gynecol. Reprod. Biol. 196 (2016) 60–63.
  • 29. O. Bektaş, K. Bektaş, C. Taşın The role of systemic inflammatory indexes in predicting preeclampsia and its severity. Perinatal Journal 2019;27(2):62-67 DOI: 10.2399/prn.19.0272003
  • 30. M.T. Gervasi, T. Chaiworapongsa, P. Pacora, N. Naccasha, B.H. Yoon, E. Maymon, et al., Phenotypic and metabolic characteristics of monocytes and granulocytes in preeclampsia, Am. J. Obstet. Gynecol. 185 (4) (2001) 792–797.
  • 31. S.W. Walsh, What causes endothelial cell activation in preeclamptic women?, Am J. Pathol. 169 (4) (2006) 1104–1106.
  • 32. Romero, R.; Gotsch, F.; Pineles, B.; Kusanovic, J.P. Inflammation in pregnancy: Its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr. Rev. 2007, 65, S194–S202
  • 33. A. Yavuzcan, M. Caglar, Y. Ustun, S. Dilbaz, I. Ozdemir, E. Yildiz, et al., Mean platelet volume, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in severe preeclampsia, Ginekol Pol. 85 (3) (2014) 197–203.
  • 34. M.A. Akıl, M.Z. Bilik, H. Acet, S.Y. Tunç, F. Ertas_, M. Aydın, et al., Mean platelet volume and neutrophil lymphocyte ratio as new markers of preeclampsia severity, Kosuyolu Heart J. 18 (2) (2015) 84–88.
  • 35. Yucel, B.; Ustun, B. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preeclampsia. Pregnancy Hypertens. 2017, 7, 29–32.
  • 36. Sisti G, Faraci A, Silva J, Upadhyay R. Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Routine Complete Blood Count Components in HELLP Syndrome: A Matched Case Control Study. Medicina (Kaunas). 2019 May 8;55(5):123.
  • 37. Gogoi, P.; Sinha, P.; Gupta, B.; Firmal, P.; Rajaram, S. Neutrophil-to-lymphocyte ratio and platelet indices in pre-eclampsia. Int. J. Gynaecol. Obstet. 2019, 144, 16–20.
  • 38. Dundar O, Yoruk P, Tutuncu L, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn. 2008;28:1052-6.
  • 39. Han L, Liu X, Li H, et al. Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia. PloS one. 2014;9:114488.
  • 40. Yoder SR, Thornburg LL, Bisognano JD. Hypertension in pregnancy and women of childbearing age. Am J Med. 2009;122:890-5

Comparison of Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR) and Mean Platelet Volume (MPV) in cases with Preeclampsia and HELLP Syndrome

Yıl 2021, Cilt 18, Sayı 4, 1083 - 1088, 31.12.2021
https://doi.org/10.38136/jgon.985290

Öz

Objective: In this study, NLR and PLR values of both HELLP syndrome and preeclampsia patients were compared with normal healthy control group. Method: This study was performed retrospectively by scanning the files of 50 HELLP syndrome, 110 severe preeclampsia (PE) and 61 control patients admitted to the Mersin University Medical Faculty Obstetrics and Gynecology Unit between 2012-2020. In the study, patients with HELLP syndrome and preeclampsia were compared with a healthy control group. Patients with additional disease were excluded from the study. Venous blood hemogram parameters of the patient groups and biochemical values obtained during delivery were recorded. Patients' age, gestational week, liver function tests, kidney function tests, hemogram parameters, NLR and PLR values and complications were compared. Ethical consent of the study was obtained (Date of decision: 28/04/2021; Decision number: 343). Results: In the study, the neutrophil count was found to be significantly higher in the HELLP syndrome group compared to the control group (9493 and 7210, respectively, p=0.04). NLR was higher in both HELLP syndrome and PE groups compared to the control group (It was significantly higher in the HELLP syndrome group compared to the control group (5.47 and 3.66, respectively, p = 0.02)). PLR was found to be lower in both the HELLP syndrome and PE groups compared to the control group ((In the HELLP syndrome group, compared to control group (72 and 111.18, respectively, p = 0.0001) and PE group (72 and 107.75, respectively, p= 0.0002) was found to be significantly low)). There was a significant difference in the number of platelets between all groups (in the HELLP syndrome group, it was found to be significantly lower than the PE group (139.181 and 196.222, respectively, p = 0.0002) and the control group (139.181 and 222.639, respectively, p = 0.0001). In addition, it was found to be significantly lower in the PE group compared to the control group (196.222 and 222.639, respectively, p = 0.003). MPV was found to be significantly lower in the HELLP syndrome group compared to the control group (9.95 and 11.13, respectively, p = 0.04). Conclusion: In our study, it was concluded that the increase in NLR and the decrease in PLR and MPV, which are inflammatory markers, can be used both in the diagnosis of HELLP syndrome and in the differentiation of HELLP syndrome and PE. Keywords: HELLP syndrome, Neutrophil- lymphocyte ratio, Mean platelet volume, Preeclampsia, Platelet-lymphocyte ratio.

Kaynakça

  • 1. American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin No. 222: Gestational Hypertension and Preeclampsia. Obstet Gynecol 2020; 135:e237.
  • 2. T.Y. Wong, H. Groen, M.M. Faas, M.G. van Pampus, Clinical risk factors for gestational hypertensive disorders in pregnant women at high risk for developing preeclampsia, Pregnancy Hypertens. 3 (4) (2013) 248–253.
  • 3. Harmon, A.C., Cornelius, D.C., Amaral, L.M., Faulkner, J.L., Cunningham Jr, M.W., Wallace, K., LaMarca, B., 2016. The role of inflammation in the pathology of preeclampsia. Clin. Sci. (Lond). 130 (6), 409–419.
  • 4. E. Laresgoiti-Servitje, N. Gomez-Lopez, D.M. Olson, An immunological insight into the origins of pre-eclampsia, Hum. Reprod. Update 16 (5) (2010) 510–524.
  • 5. W.W. Zhang, K.J. Liu, G.L. Hu, W.J. Liang, Preoperative platelet/lymphocyte ratio is a superior prognostic factor compared to other systemic inflammatory response markers in ovarian cancer patients, Tumour Biol. 36 (11) (2015) 8831–8837.
  • 6. Canzoneri, B.J.; Lewis, D.F.; Groome, L.; Wang, Y. Increased neutrophil numbers account for leukocytosis in women with preeclampsia. Am. J. Perinatol. 2009, 26, 729–732.
  • 7. Al Sheeha, M.A.; Alaboudi, R.S.; Alghasham, M.A.; Iqbal, J.; Adam, I. Platelet count and platelet indices in women with preeclampsia. Vasc. Health Risk Manag. 2016, 12, 477–480.
  • 8. Mannaerts, D.; Heyvaert, S.; de Cordt, C.; Macken, C.; Loos, C.; Jacquemyn, Y. Are neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and/or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia? J. Matern. Fetal Neonatal. Med. 2019, 32, 1412–1419.
  • 9. Serin, S.; Avcı, F.; Ercan, O.; Köstü, B.; Bakacak, M.; Kıran, H. Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia? Pregnancy Hypertens. 2016, 6, 22–25.
  • 10. Cintesun, E.; Incesu Cintesun, F.N.; Ezveci, H.; Akyurek, F.; Celik, C. Systemic inflammatory response markers in preeclampsia. J. Lab. Phys. 2018, 10, 316–319
  • 11. R.K. Kurt, Z. Aras, D.B. Silfeler, C. Kunt, M. Islimye, O. Kosar, Relationship of red cell distribution width with the presence and severity of preeclampsia, Clin.Appl. Thromb. Hemost. 21 (2) (2015) 128–131.
  • 12. A. Karateke, R.K. Kurt, A. Baloglu, Relation of platelet distribution width (PDW) and platelet crit (PCT) to preeclampsia, Ginekol Pol. 86 (5) (2015) 372–375.
  • 13. A. Kirbas, A.O. Ersoy, K. Daglar, T. Dikici, E.H. Biberoglu, O. Kirbas, et al., Prediction of preeclampsia by first trimester combined test and simple complete blood count parameters, J. Clin. Diagn. Res. 9 (11) (2015). QC20-3.
  • 14. H. Abdullahi, A. Osman, D.A. Rayis, G.I. Gasim, A.M. Imam, I. Adam, Red blood cell distribution width is not correlated with preeclampsia among pregnant Sudanese women, Diagn Pathol. 9 (2014) 29.
  • 15. Gezer, C.; Ekin, A.; Ertas, I.E.; Ozeren, M.; Solmaz, U.; Mat, E.; Taner, C.E. High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia. Ginekol. Pol. 2016;87(6):431-5.
  • 16. Agrawal, N.; Yadav, P.; Bishnoi, S.; Fayyaz, S. Can High First Trimester NLR And PLR is Early Predictor for Preeclampsia?: An Experience of Single Tertiary Care Center. Arch. Reprod. Med. Sex. Health 2018, 1, 3–7.
  • 17. Sachan, R.; Lal Patel, M.; Solanki, V.; Sachan, P.; Shyam, R. Diagnostic accuracy of neutrophil to lymphocyte ratio in prediction of nonsevere preeclampsia and severe preeclampsia. J. Curr. Res. Sci. Med. 2017.
  • 18. Ferrazzi, E.; Stampalija, T.; Monasta, L.; Di Martino, D.; Vonck, S.; Gyselaers,W. Maternal hemodynamics: A method to classify hypertensive disorders of pregnancy. Am. J. Obstet. Gynecol. 2018. Jan:218(1):124.e1-124.e11
  • 19. Stone JH. HELLP syndrome: hemolysis, elevated liver enzymes, and low platelets. JAMA1998; 280:559.
  • 20. Kinay, T.; Kucuk, C.; Kayikcioglu, F.; Karakaya, J. Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at <34 and _34 Weeks’ Gestation. Balkan Med. J. 2015, 32.
  • 21. Vigil-de Gracia, P.E.; Tenorio-Maranon, F.R.; Cejudo-Carranza, E.; Helguera-Martinez, A.; Garcia-Caceres, E. [Di_erence between preeclampsia, HELLP syndrome and eclampsia, maternal evaluation]. Ginecol. Obstet. Mex. 1996, 64, 377–382.
  • 22. Sibai BM, Taslimi MM, el-Nazer A, et al. Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsiaeclampsia. Am J Obstet Gynecol 1986; 155:501
  • 23. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am J Obstet Gynecol 1990; 162:311.
  • 24. Cornelius, D.C. Preeclampsia: From Inflammation to Immunoregulation. Clin. Med. Insights Blood Disord. 2018, 11, 1179545X17752325
  • 25. I. Ann-Charlotte, Inflammatory mechanisms in preeclampsia, Pregnancy Hypertens. 3 (2) (2013) 58.
  • 26. I. Sari, M. Sunbul, C. Mammadov, E. Durmus, M. Bozbay, T. Kivrak, et al.,Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography, Kardiol. Pol. 73 (12) (2015) 1310–1316.
  • 27. H.Q. Ying, Q.W. Deng, B.S. He, Y.Q. Pan, F. Wang, H.L. Sun, et al., The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients, Med. Oncol. 31 (12) (2014) 305.
  • 28. K.D. Seckin, M.F. Karsli, B. Yucel, M. Bestel, D. Yildirim, E. Canaz, et al., The utility of tumor markers and neutrophil lymphocyte ratio in patients with an intraoperative diagnosis of mucinous borderline ovarian tumor, Eur. J. Obstet. Gynecol. Reprod. Biol. 196 (2016) 60–63.
  • 29. O. Bektaş, K. Bektaş, C. Taşın The role of systemic inflammatory indexes in predicting preeclampsia and its severity. Perinatal Journal 2019;27(2):62-67 DOI: 10.2399/prn.19.0272003
  • 30. M.T. Gervasi, T. Chaiworapongsa, P. Pacora, N. Naccasha, B.H. Yoon, E. Maymon, et al., Phenotypic and metabolic characteristics of monocytes and granulocytes in preeclampsia, Am. J. Obstet. Gynecol. 185 (4) (2001) 792–797.
  • 31. S.W. Walsh, What causes endothelial cell activation in preeclamptic women?, Am J. Pathol. 169 (4) (2006) 1104–1106.
  • 32. Romero, R.; Gotsch, F.; Pineles, B.; Kusanovic, J.P. Inflammation in pregnancy: Its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr. Rev. 2007, 65, S194–S202
  • 33. A. Yavuzcan, M. Caglar, Y. Ustun, S. Dilbaz, I. Ozdemir, E. Yildiz, et al., Mean platelet volume, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in severe preeclampsia, Ginekol Pol. 85 (3) (2014) 197–203.
  • 34. M.A. Akıl, M.Z. Bilik, H. Acet, S.Y. Tunç, F. Ertas_, M. Aydın, et al., Mean platelet volume and neutrophil lymphocyte ratio as new markers of preeclampsia severity, Kosuyolu Heart J. 18 (2) (2015) 84–88.
  • 35. Yucel, B.; Ustun, B. Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preeclampsia. Pregnancy Hypertens. 2017, 7, 29–32.
  • 36. Sisti G, Faraci A, Silva J, Upadhyay R. Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Routine Complete Blood Count Components in HELLP Syndrome: A Matched Case Control Study. Medicina (Kaunas). 2019 May 8;55(5):123.
  • 37. Gogoi, P.; Sinha, P.; Gupta, B.; Firmal, P.; Rajaram, S. Neutrophil-to-lymphocyte ratio and platelet indices in pre-eclampsia. Int. J. Gynaecol. Obstet. 2019, 144, 16–20.
  • 38. Dundar O, Yoruk P, Tutuncu L, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn. 2008;28:1052-6.
  • 39. Han L, Liu X, Li H, et al. Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia. PloS one. 2014;9:114488.
  • 40. Yoder SR, Thornburg LL, Bisognano JD. Hypertension in pregnancy and women of childbearing age. Am J Med. 2009;122:890-5

Ayrıntılar

Birincil Dil Türkçe
Konular Kadın Hastalıkları ve Doğum
Bölüm Araştırma Makaleleri
Yazarlar

Cuma TAŞIN>
MERSİN ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, KADIN HASTALIKLARI VE DOĞUM ANABİLİM DALI
0000-0002-9315-4791
Türkiye


Serhat AKCAN> (Sorumlu Yazar)
MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ
0000-0001-8688-8802
Türkiye

Yayımlanma Tarihi 31 Aralık 2021
Başvuru Tarihi 20 Ağustos 2021
Kabul Tarihi 7 Kasım 2021
Yayınlandığı Sayı Yıl 2021, Cilt 18, Sayı 4

Kaynak Göster

Vancouver Taşın C. , Akcan S. Preeklampsi ve HELLP Sendromlu Olgularda Nötrofil-Lenfosit Oranı (NLO), Platelet-Lenfosit Oranı (PLO) ve Ortalama Platelet Hacminin (OPH) Karşılaştırılması. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2021; 18(4): 1083-1088.