Gebelerde düşük molekül ağırlıklı heparin kullanımının sistemik immün-inflamasyon indeksi üzerine etkisi

Yıl 2022, Cilt: 19 Sayı: 3, 1344 - 1349, 30.09.2022

Deniz Oluklu , Şule Göncü Ayhan , Mehmet Keven Dilek Sahin

https://doi.org/10.38136/jgon.956301

Öz

Amaç Gebelerde Düşük Molekül Ağırlıklı Heparin (DMAH) kullanımı sonrası inflamasyon belirteçlerinin değişiminin saptanması amaçlanmıştır.
Gereç ve Yöntemler Gebeliğinde DMAH kullanan 57 hastanın DMAH kullanımı öncesi ve bir ay sonrası hemogram tetkikindeki parametreler kullanılarak hesaplanan, NLO (Nötrofil Lenfosit Oranı), TLO (Trombosit Lenfosit Oranı), LMO (Lenfosit Monosit Oranı) ve SII (Sistemik İmmün-inflamasyon İndeks) (Nötrofil x Trombosit / Lenfosit) karşılaştırıldı.
Bulgular DMAH kullanımı sonrasında OEDG (Ortalama eritrosit dağılım genişliği), OTH (ortalama trombosit hacmi), OTDG (Ortalama trombosit dağılım genişliği), NLO ve SII anlamlı olarak artarken; platekrit, LMO anlamlı olarak azalmış olarak saptandı (p<0,05). Ayrıca TLO anlamlı olarak değişmemişti.
Sonuç DMAH'nin anti inflamatuar sürece katkısını göstermek için teknik olarak ucuz ve uygulanabilir olan hemogram parameterlerinden OTH, OTDG ve platekrit kullanılabilir. Bu parametreler DMAH kullanan gebelerin takibinde klinisyenlere yardımcı olabilir. DMAH'nin gebelik sonuçlarını iyileştirmesinde antikoagülan etkisinin yanı sıra anti inflamatuar etkisinin olabileceği sonucuna varılmıştır.

Anahtar Kelimeler

Düşük molekül ağırlıklı heparin, hemogram, OTH, OTDG, platekrit, Sistemik İmmün-inflamasyon İndeksi

The effect of low molecular weight heparin on the systemic immune-inflammation index in pregnancy

Öz

Aim The aim of this study was to investigate the effect of low molecular weight heparin (LMWH) use on inflammatory markers.
Material and Methods: Fifty-seven pregnant women were enrolled in this study. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), lymphocyte monocyte ratio (LMR), and systemic immune-inflammation index (SII) (Neutrophil x Platelet / Lymphocyte) were calculated using complete blood count parameters. These parameters were compared before and after one month usage of LMWH. .
Results After the usage of LMWH , mean erythrocyte distribution width (RDW), mean platelet volume (MPV), mean platelet distribution width (PDW) , NLR, and SII increased and platecrite, and LMR decreased significantly (p <0.05). Also, there was no change in TLR.
Conclusion In order to see anti-inflammatory effect of LMWH easily and cost effectively MPV, PDW, platecrite may be used. These parameters might be helpful in LWMH prescribed patient follow-ups. LMWH might be associated with better pregnancy outcomes as a result of both anticoagulation and anti-inflammatory effects.

Anahtar Kelimeler

Low Molecular Weight Heparin, Complete Blood Count, MPV, PDW, Platecrite, LMR, Systemic Immune-inflammation Index

Kaynakça

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