A comprehensive look at inflammation in RLS: assessing NLR, MLR, PLR, SII, SIRI, and microR

Abstract

Aims: Restless legs syndrome (RLS) has been linked to systemic inflammation. The number of studies investigating inflammation in RLS patients is extremely limited. The purpose of this study is to examine the possible role of proinflammatory parameters in RLS, specifically neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and microR. Methods: The study included 100 patients admitted to the neurology outpatient clinic diagnosed with RLS using the International Restless Legs Syndrome Study Group ((IRLSSG) scale and 100 healthy controls. Hemogram results were obtained from both RLS patients and healthy controls, while ferritin, folate, vitamin D and B12, and C-reactive protein (CRP) levels were obtained only from RLS patients. Results: The median age of the patient group was 52.50 (43-60.75), while the median age of the healthy group was 51.00 (50-53). The patient group is 37% male, while the healthy group is 34% male. It doesn't vary by age or gender (p=0.658). The two groups showed significant differences in PLR (<0.001), MLR (0.035), microR (p=0.023), and SIRI (p=0.022). There was no statistically significant difference in NLR, SII, and macroR levels between the two groups. Conclusion: In the current study, the inflammatory variables PLR, MLR, and microR were significantly lower, and SIRI was significantly higher from healthy control groups.

Keywords

• Restless Legs Syndrome
• NLR
• PLR
• MLR
• SII
• SIRI
• microR

Supporting Institution

NO

Project Number

2023-KAEK-156

Ethical Statement

KASTAMONU UNIVERSITY CLINICAL RESEARCH ETHICS COMMITTEE

Thanks

NO

References

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