Relationship between 25-OH-D3 levels and cognitive functions in children with obesity

Yıl 2024, , 524 - 528, 27.09.2024

Samet Özer , Hasan Bozkurt , İlknur Bütün

https://doi.org/10.32322/jhsm.1524634

Öz

Aims: The inconsistent results about neurocognitive functions in children with obesity may be suggestive of factors like vitamin deficiencies rather than the disorder itself. So we aimed to investigate the 25(OH)D3 levels and cognitive functions in obese children in the present study.
Methods: Seventy-two children were included to this study. Forty-one of them were obese children and 31 children were with normal weight. The patients were diagnosed as obese according to body mass index >95 percentile, considering the sex and age-specific growth curves for Turkish children. The participants completed the battery tests of the central nervous system vital signs (CNSVS), a neurocognitive test battery, via computer. The battery calculates seven domain scores (Memory, Psychomotor speed, Processing speed, Reaction time, Complex attention, Executive function, Cognitive flexibility) and a summary score (Neurocognition Index). 25(OH)D3 levels were measured in residual samples using a Shimadzu HPLC system with the aid of a 25(OH)D3 kit. The scores were compared by using commercial software (IBM SPSS Statistics 18).
Results: The mean 25-OH-vitamin D levels were 13.41±7.91 µg/L in obese children and 20.31±5.92µg/L in controls. Vitamin D3 levels were significantly lower in obese children than in control group (p<0.05). There was statistically significant difference between patient and healthy control group on all cognitive performance domains. Mean NCI score of obesity group was 86.17±8.85, whereas that of healthy participants was 90.61±8.28. The mean NCI score in the obesity group was significantly lower than that of the control group (p<0.001).
Conclusion: Cognitive index of obese children is lower than normal weight children. Lower 25(OH)D3 levels are related to cognitive deficits in children with obesity. Cognitive dysfunction and 25(OH)D3 levels in obese children and adolescents should be addressed in the evaluation and treatment of this population.

Anahtar Kelimeler

Child, obesity, 25-OH-vitamin D, cognitive dysfunction

Kaynakça

• Weiss R, Bremer AA, Lustig RH. What is metabolic syndrome, and why are children getting it? Ann N Y Acad Sci. 2013;1281(1): 123-140. doi:10.1111/nyas.12030
• Gobato AO, Vasques AC, Zambon MP, Barros Filho Ade A, Hessel G. Metabolic syndrome and insulin resistance in obese adolescents. Rev Paul Pediatr. 2014;32(1):55-62.
• Andıran N, Çelik N, Akça H, Doğan G. Vitamin D deficiency in children and adolescents. J Clin Res Pediatr Endocrinol. 2012;4(1):25-29. doi:10.4274/jcrpe.574
• Plesner JL, Dahl M, Fonvig CE, et al. Obesity is associated with vitamin D deficiency in Danish children and adolescents. J Pediatr Endocrinol Metab. 2018;31(1):53-61. doi:10.1515/jpem-2017-0246
• Lagunova Z, Porojnicu AC, Lindberg FA, Aksnes L, Moan J. Vitamin D status in Norwegian children and adolescents with excess body weight. Pediatr Diabetes. 2011;12(2):120-126. doi:10.1111/j.1399-5448.2010.00672.x
• Rajakumar K, Fernstrom JD, Holick MF, Janosky JE, Greenspan SL. Vitamin D status and response to vitamin D (3) in obese vs. non-obese African American children. Obesity (Silver Spring). 2008;16(1):90-95. doi:10.1038/oby.2007.23
• Dye L, Boyle NB, Champ C, Lawton C. The relationship between obesity and cognitive health and decline. Proc Nutr Soc. 2017; 76(4):443-454. doi:10.1017/S0029665117002014
• Davis CL, Tomporowski PD, Boyle CA, et al. Effects of aerobic exercise on overweight children’s cognitive functioning: a randomized controlled trial. Res Q Exerc Sport. 2007;78(5):510-519. doi:10.1080/02701367.2007.10599450
• Ronan L, Alexander-Bloch A, Fletcher PC. Childhood obesity, cortical structure, and executive function in healthy children. Cereb Cortex. 2020;30(4):2519-2528. doi: 10.1093/cercor/bhz257
• Staiano AE, Abraham AA, Calvert SL. Competitive versus cooperative exergame play for African American adolescents’ executive function skills: short-term effects in a long-term training intervention. Dev Psychol. 2012;48(2):337-342.
• Reger MA, Watson GS, Frey WH 2nd, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27(3):451-458. doi:10.1016/j.neurobiolaging.2005.03.016
• Erbaş O, Solmaz V, Aksoy D, Yavaşoğlu A, Sağcan M, Taşkıran D. Cholecalciferol (vitamin D 3) improves cognitive dysfunction and reduces inflammation in a rat fatty liver model of metabolic syndrome. Life Sci. 2014;103(2):68-72. doi:10.1016/j.lfs.2014.03.035
• Argano C, Mirarchi L, Amodeo S, Orlando V, Torres A, Corrao S. The role of vitamin D and its molecular bases in insulin resistance, diabetes, metabolic syndrome, and cardiovascular disease: state of the art. Int J Mol Sci. 2023;24(20):15485. doi:10.3390/ijms242015485
• Annweiler C, Allali G, Allain P, et al. Vitamin D and cognitive performance in adults: a systematic review. Eur J Neurol. 2009;16(10):1083-1089. doi:10.1111/j.1468-1331.2009.02755.x
• Yılmaz M, Yılmaz N. D Vitaminin beyindeki rolü ve ilişkili nörolojik hastalıklar. J Clin Exp Invest. 2013.4(3).
• Neyzi O, Günöz H, Furman A, et al. Türk çocuklarinda vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri. Çocuk Sağ Hast Derg. 2008;51:1-14.
• Gualtieri CT, Johnson LG. Reliability and validity of a computerized neurocognitive test battery, CNS vital signs. Arch Clin Neuropsychol. 2006;21(7):623-643. doi: 10.1016/j.acn.2006.05.007
• Brooks BL, Holdnack JA, Iverson GL. Reliable change on memory tests is common in healthy children and adolescents. Arch Clin Neuropsychol. 2017;32(8):1001-1009. doi: 10.1093/arclin/acx028
• Rosengren A, Teo K, Rangarajan S, et al. Psychosocial factors and obesity in 17 high-, middle- and low-income countries: the prospective urban rural epidemiologic study. Int J Obes (Lond). 2015;39(8):1217-1223. doi:10.1038/ijo.2015.48
• Tosunbayraktar G, Bas M, Kut A, Buyukkaragoz AH. Low serum 25 (OH) D levels are assocıated to hıgher BMI and metabolic syndrome parameters in adult subjects in Turkey. Afr Health Sci. 2015;15(4):1161-1169. doi:10.4314/ahs.v15i4.15
• Vranić L, Mikolašević I, Milić S. Vitamin D deficiency: consequence or cause of obesity? Medicina (Kaunas). 2019;55(9):541. doi: 10.3390/medicina55090541
• Fiamenghi VI, Mello ED. Vitamin D deficiency in children and adolescents with obesity: a meta-analysis. J Pediatr (Rio J). 2021;97(3):273-279. doi: 10.1016/j.jped.2020.08.006
• Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015;16(4):341-349. doi:10.1111/obr.1223924
• Grasemann H, Holguin F. Oxidative stress and obesity-related asthma. Paediatr Respir Rev. 2021;37:18-21. doi: 10.1016/j.prrv. 2020.05.004
• Li Y, Dai Q, Jackson JC, Zhang J. Overweight is associated with decreased cognitive functioning among school-age children and adolescents. Obesity (Silver Spring). 2008;16(8):1809-1815. doi:10.1038/oby.2008.296
• Halfon N, Larson K, Slusser W. Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17. Acad Pediatr. 2013;13(1):6-13. doi: 10.1016/j.acap. 2012.10.007
• Liang J, Matheson BE, Kaye WH, Boutelle KN. Neurocognitive correlates of obesity and obesity-related behaviors in children and adolescents. Int J Obes (Lond). 2014;38(4):494-506.
• Harse JD, Marriott RJ, Zhu K, Murray K, Bucks RS. Vitamin D status and cognitive performance in community-dwelling adults: a dose-response meta-analysis of observational studies. Front Neuroendocrinol. 2023;70:101080. doi:10.1016/j.yfrne.2023.101080
• Guo J, Mo H, Zuo L, Zhang X. Association of physical activity and vitamin D deficiency with cognitive impairment in older adults: a population based cross-sectional analysis. Front Nutr. 2024;11:1390903. doi:10.3389/fnut.2024.1390903
• Almuqbil M, Almadani ME, Albraiki SA, et al. Impact of vitamin D deficiency on mental health in university students: a cross-sectional study. Healthcare (Basel). 2023;11(14):2097. doi:10.3390/healthcare11142097
• Tan X, Gao L, Cai X, et al. Vitamin D3 alleviates cognitive impairment through regulating inflammatory stress in db/db mice. Food Sci Nutr. 2021;9(9):4803-4814. doi:10.1002/fsn3.2397
• Xie Y, Bai C, Feng Q, Gu D. Serum vitamin D3 concentration, sleep, and cognitive impairment among older adults in China Nutrients. 2023;15(19):4192. doi:10.3390/nu15194192