Kolorektal kanserli hastalarda metastatik karaciğer lezyonlarının geç faz FDG-PET/BT görüntülemesinin değerlendirilmesi

Abstract

Amaç: Amacımız, karaciğer metastazı olan kolorektal karsinom hastalarında F18-FDG-PET / BT ile geç faz görüntülemenin rolünü araştırmaktır. Gereç ve Yöntem: Karaciğer metastazı olan kolorektal karsinomlu hastalarda çift fazlı FDG-PET / BT taraması retrospektif olarak incelendi. FDG enjeksiyonundan sonra 92-253 dakika (ortalama 158.53 ± 35.7 dakika) geç faz görüntüleme alındı. 37 hastada altmış sekiz metastatik lezyon saptandı. Ortalama lezyon SUVmax ve lezyon-tümör olmayan karaciğer doku oranı hesaplandı ve rutin FDG-PET görüntüleme sonuçları geç faz görüntüleme sonuçları ile karşılaştırıldı. Bulgular: Metastatik lezyon boyutları 9-230 mm idi (ortalama 3.71 ± 3.7 cm). Rutin ve geç evre görüntüleme için metastaz ve tümörsüz karaciğer SUVmax değerleri SUVmax olarak; 7,19 ± 3,8, 10,3 ± 5,4; Sırasıyla 2.98 ± 0.7, 2.41 ± 0.6. Geç evre görüntülemede metastatik karaciğer lezyonları, SUVmax değerleri artmış (p0.01) ve tümör olmayan karaciğer SUVmax değerleri azalmıştır (p0.01). Rutin görüntülemeye kıyasla geç faz lezyonunda tümörsüz karaciğer dokusuna artmıştı (p = 0.001). Lezyon retansiyon indeksi % 45.74 ± 31.8 ve tümör olmayan karaciğer indeksi% 18.63 ± 10.4 azaldı. Sonuç: Bulgularımıza göre, normal karaciğer FDG alımının zamanla azaldığını ve geç faz görüntülemenin, tümörün normal doku oranını belirginleştirdiği ve metastatik karaciğer lezyonlarının normal karaciğerden daha kolay ayırt edilmesini sağladığını göstermektedir.

Keywords

• Geç faz,FDG-PET,Karaciğer metastazları,Kolorektal Karsinom

The value of late phase imaging with FDG-PET/CT in liver metastases of colorectal carcinoma

Abstract

Aim: Our aim was investigated the role of late phase imaging with F18-FDG-PET/CT in colorectal carcinoma patients with liver metastases. Method: Dual phase FDG-PET/CT scan was retrospectively evaluated in colorectal carcinoma patients with liver metastases. Late phase imaging was acquired 92-253 minutes (mean 158.53±35.7 minutes) after the FDG injection. Sixty-eight metastatic lesions were determined in 37 patients. Mean lesion SUVmax and lesion-to non-tumorous liver tissue ratio were calculated and results of routine FDG-PET imaging were compared with late phase imaging. Results: Metastatic lesion sizes were 9 to230 mm (mean 3.71±3.7 cm). SUVmax values of the metastasis and non-tumorous liver SUVmax for routine and late-phase imaging were as follows; 7.19±3.8, 10.3±5.4; 2.98±0.7, 2.41±0.6 respectively. Metastatic liver lesions, SUVmax values were increased (p 0.01) and non-tumorous liver SUV max values were decreased (p 0.01) in late phase imaging. Compared to routine imaging, in late phase lesion to non-tumorous liver tissue was increased (p 0.001). Lesion retention index was 45.74± 31.8% and the non-tumorous liver index was decreased 18.63 ± 10.4%. Conclusion: The results of this study indicates that normal liver FDG uptake decreases in time and late phase imaging improves the tumor to normal tissue ratio and enable differentiation of metastatic liver lesions from normal liver.

Keywords

• Dual Phase,FDG-PET,Liver metastases,Colorectal carcinoma

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