Spectrum of eyelid lesions-a histopathological study in South India

Abstract

ABSTRACT Eyelids are complex structures that protect the anterior surface of the globe. Eyelid lesions range from benign, self limiting conditions to malignant, possibly metastatic tumors. Aim To assess the histomorphology of various eyelid lesions, determine their frequency, age and sex distribution in our study population and compare them with the other studies. Materials and Methods This is a retrospective study involving 122 patients of either sex presenting with lesions involving the eyelid, reporting to a tertiary care hospital in Karnataka. Results We came across 67.72% neoplastic, 28.34% inflammatory/ infectious, and 3.94% miscellaneous lesions. There was a slight female predominance with a male to female ratio of 1:1.18. The mean age at presentation was 43.7 years, range being 1-90 years. Majority were in their 3rd and 4th decades. Among the neoplastic lesions, 90.7% were benign. The most common benign, malignant and inflammatory lesions were nevus, sebaceous carcinoma and chalazion respectively. Uncommon stromal lesions, such a s fibrous histiocytoma and a rare variant of basal cell carcinoma with sebaceous differentiation were encountered. Conclusion The frequency of eyelid lesions depends upon age group, source institution, racial and geographic factors. Histopathology remains the mainstay for diagnosis. In addition to determining the malignant potential of a lesion, it reveals its exact nature and structure, thereby influencing management and prognosis.

Keywords

• eyelid
• nevus
• chalazion

Göz kapağı lezyonları spektrumu-Güney Hindistan'da histopatolojik bir çalışma

Abstract

Göz kapakları, kürenin ön yüzeyini koruyan karmaşık yapılardır. Göz kapağı lezyonları iyi huylu, kendi kendini sınırlayan durumlardan kötü huylu, muhtemelen metastatik tümörlere kadar değişir. Amaç Çeşitli göz kapağı lezyonlarının histomorfolojisini değerlendirmek için, çalışma popülasyonumuzdaki sıklığını, yaşını ve cinsiyet dağılımını belirlemek ve diğer çalışmalarla karşılaştırmak. Malzemeler ve yöntemler Bu retrospektif bir çalışmadır, her iki cinsiyetten 122 hastanın göz kapağını tutan lezyonlarla başvurması ve Karnataka'daki bir üçüncü basamak hastanesine bildirilmesi. Sonuçlar % 67.72 neoplastik,% 28.34 enflamatuar / enfeksiyöz ve% 3.94 çeşitli lezyonlarla karşılaştık. 1: 1.18 erkek / kadın oranı ile hafif bir kadın üstünlüğü vardı. Başvuru anındaki ortalama yaş 43.7, 1-90 yıl arasında değişiyordu. Çoğunluk 3. ve 4. dekadlarında idi. Neoplastik lezyonların% 90.7'si benign idi. En sık görülen benign, malign ve inflamatuvar lezyonlar sırasıyla nevüs, sebasöz karsinom ve sarkma idi. Nadir görülen stromal lezyonlar, böyle bir fibröz histiyositoma ve sebasöz farklılaşmalı nadir bir bazal hücreli karsinom varyantı ile karşılaşıldı. Sonuç Göz kapağı lezyonlarının sıklığı yaş grubuna, kaynak kuruma, ırksal ve coğrafi faktörlere bağlıdır. Histopatoloji, tanı için temel dayanaktır. Bir lezyonun kötü huylu potansiyelini belirlemenin yanı sıra, kesin doğasını ve yapısını ortaya çıkarır, böylece yönetimi ve prognozu etkiler.

Keywords

• göz kapağı
• nevüs
• şalazyon

References

1. Reference 1. Yanoff M, Sassani J W. Ocular Pathology. 7th ed. Philadelphia:Elsevier Saunders;2015.
2. Reference 2. Folberg R. Tumors of the eye and ocular adnexa. In:Diagnostic Histopathology of Tumors. Fletcher CDM.4th ed. Philadelphia: Elsevier Saunders; 2013: 2086-116.
3. Reference 3. Pe’er J. Pathology of eyelid tumors. Indian J Ophthalmol 2016;64:177-90.
4. Reference 4. Singh U, Kolavali RR. Overview of Eyelid Tumors. In:Surgical Ophthalmic Oncology. Chaugule SS, Honavar SG, Finger PT (eds). Switzerland: Springer; 2019:3-10.
5. Reference 5. Bagheri A, Tavakoli M, Kanaani A, Zavareh RB, Esfandiari H, Aletaha M et al.Eyelid Masses: A 10-year Survey from a Tertiary Eye Hospital in Tehran. Middle East Afr J Ophthalmol 2013;20:187-92.
6. Reference 6. Xu XL, Li B, Sun XL, Li LQ, Ren RJ, Gao F et al. Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006. Ophthalmic Surg Lasers Imaging. 2008 Sep-Oct;39(5):367-72. PubMed PMID: 18831417.
7. Reference 7. Kaliki S, Bothra N, Bejjanki KM, Nayak A, Ramappa G, Mohamed A et al. Malignant Eyelid Tumors in India: A Study of 536 Asian Indian Patients. Ocul Oncol Pathol. 2019;5(3):210–219. PubMed PMID: 31049330
8. Reference 8. Patel M, Chavda BH, Shah Y, Bhavsar M. Study of Incidence, Occurrence, Origin, and Histological Types of Eyelid Tumors at Tertiary Care Hospital in Ahmedabad. Int J Sci Stud 2019;6(10):16-19.

9. Reference 9. Coroi MC, Roşca E, Muţiu G, Coroi T, Bonta M. Eyelid tumors: histopathological and clinical study performed in County Hospital of Oradea between 2000-2007. Rom J Morphol Embryol. 2010;51(1):111-5. PubMed PMID: 20191129.
10. Reference 10. Gupta P, Gupta RC, Khan L. Profile of eyelid malignancy in a Tertiary Health Care Center in North India. J Can Res Ther 2017;13:484-6.
11. Reference 11. Ozdal PC, Callejo SA, Codère F, Burnier MN Jr. Benign ocular adnexal tumours of apocrine, eccrine or hair follicle origin. Can J Ophthalmol. 2003 Aug;38(5):357-63. PubMed PMID: 12956276.
12. Reference 12. Deprez M, Uffer S. Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol 2009;31(3):256-62.
13. Reference 13. Al-FakyYH. Epidemiology of benign eyelid lesions in patients presenting to a teaching hospital. Saudi J Ophthalmol 2012;26:211-6.
14. Reference 14. Al-Buloushi A, Filho JP, Cassie A, Arthurs B, Burnier A report of three cases. Eye 2005;19:1313-4.
15. Reference 15. Shields JA, Demirci H, Marr BP, Eagle RC Jr, Shields CL. Sebaceous carcinoma of the eyelids: personal experience with 60 cases. Ophthalmology. 2004 Dec;111(12):2151-7. Review. PubMed PMID: 15582067.
16. Reference 16. Ni C, Searl SS, Kuo PK, Chu FR, Chong CS, Albert DM. Sebaceous cell carcinomas of the ocular adnexa. Int Ophthalmol Clin 1982;22:23-61.
17. Reference 17. Wang JK, Liao SL, Jou JR, Lai PC, Kao SCS, Hou PK et al. Malignant eyelid tumors in Taiwan. Eye 2003;17:216-20.
18. Reference 18. Dasgupta T, Wilson LD, Yu JB. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer. Jan 1 2009;115(1):158-165.
19. Reference 19. Kale SM, Patil SB, Khare N, Math M, Jain A, Jaiswal S. Clinicopathological analysis of eyelid malignancies - A review of 85 cases. Indian J Plast Surg. 2012 Jan;45(1):22-8. doi: 10.4103/0970-0358.96572. PMID: 22754148; PMCID: PMC3385393.
20. Reference 20. Jahagirdar SS, Thakre TP, Kale SM, Kulkarni H, Mamtani M. A clinicopathological study of eyelid malignancies from central India. Indian J Ophthalmol. 2007 Mar-Apr;55(2):109-12. PubMed PMID: 17322599.
21. Reference 21. Paul S, Vo DT, Sikliss RZ. Malignant and Benign Eyelid Lesions in San Francisco: Study of a Diverse Urban Population. American Journal of Clinical Medicine.2011.8(1): 40-6.
22. Reference 22. Asproudis I, Sotiropoulos G, Gartzios C, Raggos V, Papoudou-Bai A, Ntountas I et al. Eyelid tumors at the university eye clinic of Ioannina, Greece: A 30-year retrospective study. Middle East Afr J Ophthalmol 2015;22:230-2.
23. Reference 23. Misago N, Suse T, Uemura T, Narisawa Y. Basal Cell Carcinoma with Sebaceous Differentiation. Am J Dermatopathol. 2004;26:298–303.
24. Reference 24. Steffen CH, Ackerman AB. Basal-cell carcinoma with sebaceous differentiation. In: Steffen CH, Ackerman AB, editors. Neoplasms with Sebaceous Differentiation. Philadelphia, PA: Lea & Febiger; 1994: 577-96.
25. Reference 25. Steffen CH, Ackerman AB. Sebaceous carcinoma. In: Steffen CH, Ackerman AB, editors. Neoplasms with Sebaceous Differentiation. Philadelphia, PA: Lea & Febiger; 1994:487–574.