The effect of myometrial invasion and histological grade on lymph node metastasis in patient with early stage endometrium cancer

Abstract

Aim: Early detection of endometrial cancer is important for the prognosis of the disease. In our study, the effect of myometrial invasion and histological grade on lymph node metastasis was investigated in patient with early stage endometrium cancer . Material and Method: A total of 249 patients from the last 10 years who underwent systemic lymphadenectomy for staging in our hospital were retrospectively examined. The pathologies of these patients were limited to the uterine corpus. The effect of histological grade of tumor and myometrial invasion on lymph node metastasis was evaluated statistically. Results: The average lymph node collected from patients was 27.7 (11-78). Lymph node metastasis was detected in 4.1% of patients with histological grade 1-2 and <1/2 myometrial invasion. Lymph node metastasis was detected in 18.3% of patients with stage 1-2 tumors with myometrial invasion ≥1/2. Lymph node metastasis was detected in 11.1% of patients with myometrial invasion <1/2 and histological grade 3. Lymph node metastasis was detected in 27.3% of patients with myometrial invasion ≥1/2 and histological grade 3. Conclusions: The most important findings of our study are that histological degree and myometrial invasion are common independent markers for retroperitoneal lymph node metastasis in early stage endometrium cancers and demonstrate the necessity of lymphadenectomy.

Keywords

• Endometrium cancer
• Lymph Node Metastasis
• Staging
• Myometrial invasion

References

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