Brief review of parathyroid adenoma; problems caused by water clear cells

Abstract

Water clear cells; they can be seen in many tumors such as germ cell tumors, kidney tumors, lymphomas, sarcomas, thymic carcinomas, parathyroid carcinomas, paraganglioma. They may be primary or may occur as a result of metastatic conditions. Therefore, histopathologically differential diagnosis may be difficult or confusing. Clinical findings, radiological findings and histopathological evaluation may be required for differential diagnosis. Here, as immunohistochemically; a case with parathormone, CD10 positive and synaptophysin negative and CD10 positivity in the area where clear cells are dominant is presented. The case was reported as water clear cell (WCC) component dominant parathyroid adenoma with clinical, biochemical, radiological evaluation and histopathology and the differential diagnosis is discussed.

Keywords

• Water clear cells; parathyroid; adenomas; hyperplasia; carcinomas; metastasis
• Water clear cells
• parathyroid

References

1. Can N, Ozyılmaz F, Taştekin E. Pathological Approach to Parathyroid Diseases. Türkiye Klinikleri J Med Pathol-Special Topics 2018; 3: 107-20.
2. Bilezikian J.The Parathyroids: Basic and Clinical Concepts.3st ed. San Diego: Academic Press; 2015.
3. McCann LM, Beto J. Roles of calcium-sensing receptor and vitamin D receptor in the pathophysiology of secondary hyperparathyroidism. J Ren Nutr 2010; 20: 141-50.
4. Marini F, Cianferotti L, Giusti F, Brandi ML. Molecular genetics in primary hyperparathyroidism: the role of genetic tests in differential diagnosis, disease prevention strategy, and therapeutic planning. A 2017 update. Clin Cases Miner Bone Metab 2017; 14: 60-70.
5. Roth SI. The ultrastructure of primary water-clear cell hyperplasia of the parathyroid glands. Am J Pathol 1970; 61: 233-48.
6. Miettinen M, Clark R, Lehto VP, Virtanen I, Damjanov I. Intermediate-filament proteins in parathyroid glands and parathyroid adenomas. Arch Pathol Lab Med 1985; 109: 986-9.
7. Kanda K, Okada Y, Tanikawa T, et al. A rare case of primary hyperparathyroidism with clear cell adenoma. Endocr J 2004; 51: 207-12.
8. Arık D, Dündar E, YılmazE, Sivrikoz C. Water-clear cell adenoma of the mediastinal parathyroid gland. Turk Patoloji Derg 2019; 35: 157-61.

9. Duan K, Mete O. Parathyroid carcinoma: diagnosis and clinical implications. Turk Patoloji Derg 2015; 31: 80-97.
10. Pirela D, Treitl D, El Hussein S, Poppiti R, Mesko T, Manzano A. Intrathyroidal clear cell tumor of parathyroid origin with review of literatüre. Case Rep Pathol 2016; 2016: 7169564.
11. Vila Duckworth L, Winter WE, Vaysberg M, Moran CA, Al-Quran SZ. Intrathyroidal parathyroid carcinoma: report of an unusual case and review of the literature. Case Rep Pathol 2013; 2013: 198643.