Yıl 2020, Cilt 3 , Sayı 1, Sayfalar 36 - 41 2020-01-15

Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio

Seyfullah KAN [1] , Adnan KARAİBRAHİMOĞLU [2]


ABSTRACT

Aim: Cardiovascular risk has increased in diabetic retinopathy (DR). Brachial artery flow mediated dilation (FMD) is a non-invasive method used to evaluate endothelial dysfunction. Measurement of adhesion molecules such as E-selectin is the indirect method of predicting endothelial dysfunction. Monocyte/ HDL ratio (MHR) is a novel marker found to be related with cardiovascular diseases. In this study, in DR patients without an apparent cardiovascular disease, we aimed to investigate the relation between endothelial dysfunction indicators such as MHR, FMD, E-selectin and subclinical atherosclerosis.

Material and Method: In this study, 96 diabetic patients without apparent cardiac symptoms and 32 healthy control patients that matched for gender, age and body mass index (BMI) were included. The patients were separated into four groups as; nonproliferative diabetic retinopathy (NPDR, n=31), proliferative diabetic retinopathy (PDR, n=32), diabetic patients without a retinopathy (n=33)  and control group (n=33). Anthropometric, biochemical values and FMD were measured. Correlation and regression analysis were done for the relation between MHR and FMD.

Results: MHR was significantly high in PDR group (p<.001). E-selectin and FMD which are indicators for endothelial dysfunction were significantly different between groups (p< .001). E-selectin measures were highest in PDR group, lower in NPDR group, however it was significantly higher than DM and control groups (p= .026). Inversely proportional to E-selectin, FMD was significantly higher in control and significantly lower in PDR group (p< .001). Univariate logistic regression method was used to determine factors that had an influence on FMD. Glucose, HbA1C, CRP and MHR had a negative effect.

Conclusion: In patients with DR, MHR levels might be used as a novel non-invasive marker to determine early atherosclerotic risk.

Diabetic retinopathy, MHR, FMD, , E-Selectin
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Orcid: 0000-0001-7571-0953
Yazar: Seyfullah KAN (Sorumlu Yazar)
Kurum: Süleyman Demirel Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim dalı
Ülke: Turkey


Yazar: Adnan KARAİBRAHİMOĞLU
Kurum: Süleyman Demirel Üniversitesi Tıp Fakültesi Biyoistatistik ve Tıbbi Bilişim AD
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 15 Ocak 2020

Bibtex @araştırma makalesi { jhsm640760, journal = {Journal of Health Sciences and Medicine}, issn = {}, eissn = {2636-8579}, address = {Kırıkkale Üniversitesi Tıp Fakültesi / İç Hastalıkları Anabilim Dalı}, publisher = {MediHealth Academy Yayıncılık}, year = {2020}, volume = {3}, pages = {36 - 41}, doi = {10.32322/jhsm.640760}, title = {Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio}, key = {cite}, author = {Kan, Seyfullah and Karaibrahimoğlu, Adnan} }
APA Kan, S , Karaibrahimoğlu, A . (2020). Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio . Journal of Health Sciences and Medicine , 3 (1) , 36-41 . DOI: 10.32322/jhsm.640760
MLA Kan, S , Karaibrahimoğlu, A . "Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio" . Journal of Health Sciences and Medicine 3 (2020 ): 36-41 <https://dergipark.org.tr/tr/pub/jhsm/issue/51843/640760>
Chicago Kan, S , Karaibrahimoğlu, A . "Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio". Journal of Health Sciences and Medicine 3 (2020 ): 36-41
RIS TY - JOUR T1 - Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio AU - Seyfullah Kan , Adnan Karaibrahimoğlu Y1 - 2020 PY - 2020 N1 - doi: 10.32322/jhsm.640760 DO - 10.32322/jhsm.640760 T2 - Journal of Health Sciences and Medicine JF - Journal JO - JOR SP - 36 EP - 41 VL - 3 IS - 1 SN - -2636-8579 M3 - doi: 10.32322/jhsm.640760 UR - https://doi.org/10.32322/jhsm.640760 Y2 - 2019 ER -
EndNote %0 Journal of Health Sciences and Medicine Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio %A Seyfullah Kan , Adnan Karaibrahimoğlu %T Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio %D 2020 %J Journal of Health Sciences and Medicine %P -2636-8579 %V 3 %N 1 %R doi: 10.32322/jhsm.640760 %U 10.32322/jhsm.640760
ISNAD Kan, Seyfullah , Karaibrahimoğlu, Adnan . "Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio". Journal of Health Sciences and Medicine 3 / 1 (Ocak 2020): 36-41 . https://doi.org/10.32322/jhsm.640760
AMA Kan S , Karaibrahimoğlu A . Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio. J Health Sci Med / JHSM. 2020; 3(1): 36-41.
Vancouver Kan S , Karaibrahimoğlu A . Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio. Journal of Health Sciences and Medicine. 2020; 3(1): 36-41.
IEEE S. Kan ve A. Karaibrahimoğlu , "Three noninvasive methods in the evaluation of subclinical cardiovascular disease in patients with diabetic retinopathy: endothelial dysfunction, serum E-selectin level and monocyte to HDL ratio", Journal of Health Sciences and Medicine, c. 3, sayı. 1, ss. 36-41, Oca. 2020, doi:10.32322/jhsm.640760