Does red ginseng ameliorate liver damage caused by obstructive jaundice? : an experimental study

Yıl 2021, Cilt: 4 Sayı: 2, 233 - 239, 28.03.2021

Abdullah Durhan , Koray Koşmaz , Abdullah Şenlikci , Ender Ergüder , Marlen Süleyman , Mehmet Esat Duymuş , Yusuf Murat Bağ , Mevlüt Recep Pekcici , Mehmet Şeneş , İlknur Alkan Kuşabbi , Eylem Pınar Eser , Sema Hücümenoğlu

https://doi.org/10.32322/jhsm.900023

Cited By: 2

Öz

Aim: This experimental study aimed to evaluate the hepatoprotective effect on obstructive jaundice (OJ) of oral red ginseng (RG) extract, which is known to have anti-inflammatory and antioxidant properties.
Methods: The rats were randomly separated into 3 groups of 10 rats: the sham group, the control group, and the treatment group. In Group 1 (sham), the common bile duct (CBD) was identified but no ligation or transection was performed. In Group 2 (control), the CBD was identified and ligation and transection were performed, but no treatment was given. In Group 3 (RG group), CBD ligation and transection were performed, then RG extract was administered via an orogastric tube at a dose of 100 mg/ kg/day for 10 days. After 10 days, blood samples were taken for biochemical analysis, and liver tissue samples for biochemical and histopathological analysis.
Results: Significantly higher serum albumin levels and lower serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in the RG group than in the control group (p = 0.028, p = 0.001 and p = 0.034, respectively). In the oxidative stress parameters, malondialdehyde (MDA) levels and catalase (CAT) levels were significantly different between the RG group and control group (p = <0.001 for each). Total sulfhydryl (T-SH) was not at a statistically significant level, although it was high and approached the value of the sham group ( p = 0.076). In the histopathological evaluation, the RG group had statistically significantly lower scores in all parameters compared to the control group (p<0.05).
Conclusion: The results of this study showed that RG has a strong hepatoprotective effect as a result of its anti-inflammatory and antioxidant properties.

Anahtar Kelimeler

Red ginseng, obstructive jaundice, anti-inflammatory properties, antioxidant properties, hepatoprotective effects

Kaynakça

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