Determinants of intensive care prognosis in patients with “platelet indices” in chronic obstructive pulmonary disease and lung cancer

Yıl 2021, Cilt: 4 Sayı: 3, 329 - 333, 21.05.2021

Güler Eraslan Doğanay , Mustafa Özgür Cırık

https://doi.org/10.32322/jhsm.904057

Öz

Aim: Platelet activation and consumption indicate worse prognosis in critical ill patients. Researchers found that the lungs play an important role in the production of mature platelets. Chronic obstructive pulmonary disease(COPD) is a respiratory disease affects the lungs and also has systemic effects due to inflammation. This study was conducted to examine prognosis and mortality with Platelet indices in COPD and lung cancer patients in intensive care.
Methods: We extracted clinical datas including patient demographics, Charlson Comorbidite Index, Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment scores, length of stay in ICU, length of stay in hospital, duration of mechanical ventilation, inotrope use, Plt count, MPV, PDW, and PCT values and 30-day mortality retrospectively.
Results: This study was conducted with the 344 COPD and 84 lung cancer patients’ data analysis admitted to ICU .In this study we found that Plt count, PDW, and MPV are also predict COPD while Plt count and MPV predict lung cancer.The study shown that, CCI, APACHE II, SOFA score, intrope use, MV duration and mortality were higher in lung cancer patients compared to COPD patients.
Conclusion: Plt indices can be a determinant in patients with COPD and lung cancer but they might not make a clear distinction for prognosis.

Anahtar Kelimeler

Platelet Indices, Chronic obstructive pulmonary disease, Lung Cancer, Platelet count, MPV, intensive care

Kaynakça

• Lefrancais E, Ortiz Munoz G, Caudrillier A, et al. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature 2017; 544: 105-9.
• Nikolic I, Kukulj S, Samarzija M, et al. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio help identify patients with lung cancer, but do not differentiate between lung cancer subtypes. Croat Med J 2016; 57: 287–92.
• Omar M, Tanriverdi O, Cokmert S, et al. Role of increased mean platelet volume (MPV) and decreased MPV/platelet count ratio as poor prognostic factors in lung cancer. Clin Respir J 2018; 12: 922–9.
• Golebiewska EM, Poole AW. Platelet secretion: from hemostasis to wound healing and beyond. Blood Rev 2015; 29: 153–62.
• Hoffbrand AV, Moss PAH, Pettit JE. Essential Hematology. Blackwell Publishing, Malden MA 2006; 5: 106–10.
• Ozsarı E, Kocak MZ. Clinical significance of mean platelet volume/lymphocyte ratio and mean platelet volume/platelet ratio in the exacerbation of chronic obstructive pulmonary disease. Eur Res J 2019; 5: 6. 1001–6.
• Kalemci S, Akin F, Sarihan A, Sahin C, Zeybek A, Yilmaz N. Relationship between hematological parameters and severity of chronic obstructive pulmonary disease. Pol Arch Intern Med 2018; 128: 171–7.
• Zampieri FG, Ranzani OT, Sabatoski, et al. An increase in mean platelet volume after admission is associated with higher mortality in critically ill patients. Ann Intens Care 2014; 4: 20.
• Ghosh TK, Khan N, Malik A. Platelet auto-antibod-ies in septicaemic patients. Indian J Pathol Microbiol 1999; 42: 31–5.
• Greinacher A, Selleng K. Thrombocytopenia in the intensive care unit patient. Hematology Am Soc Hematol Educ Program Book 2010; 1: 135–43.
• Nelson RB, Kehl D. Electronically determined platelet indices in thrombocytopenic patients. Cancer. 1981; 48.4: 954–6.
• Zhang Z, Xu X, Ni H, Deng H. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 2014; 29: 885. e1-6.
• Zhang S, Cui YL, Diao MY, Chen DC, Lin ZF. Use of platelet indices for determining illness severity and predicting prognosis in critically ill patients. Chinese Med J 2015; 128.15: 2012.
• Becchi C, Al Malyan M, Fabbri LP, Marsili M, Boddi V, Boncinelli S. Mean platelet volume trend in sepsis: is it a useful parameter? Minerva Anestesiol 2006; 72.9: 749–56.
• Han L, Liu X, Li H, et al. Blood coagulation parameters and platelet indices: Changes in normal and preeclamptic pregnancies and predictive values for preeclampsia. PLoS One 2014; 9: e114488.
• Ghoshal K, Bhattacharyya M. Overview of platelet physiology: Its hemostatic and nonhemostatic role in disease pathogenesis. Scientific World Journal 2014; 781857.
• Samuel D, Bhat AN, Prabhu VM. Platelet indices as predictive markers of prognosis in critically ill patients: a prospective study. Indian J Crit Care Med 2020; 24: 817-22.
• Sezgi C, Taylan M, Kaya H, et al. Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit. Clin Respir J 2015; 9: 403-8.