The effects of anogenital condylomas on female sexuality and psychology: a case-control study

Yıl 2021, Cilt: 4 Sayı: 4, 482 - 487, 15.07.2021

Eser Ağar , Seda Şahin Aker

https://doi.org/10.32322/jhsm.933593

Öz

Objective: HPV is a sexually transmitted virus with over two hundred subtypes. It can cause anogenital condyloma, cervical dysplasia, and cervical cancer. HPV types 6 and 11 are responsible for anogenital condylomas. The effect of condylomas on female sexual life and psychological state is investigated in our study.
Material and Methods: Seventy-six vulvar condyloma patients and 80 participants as the control group were included in the study after excluding the subjects not meeting the inclusion criteria. After an initial evaluation, condylomas excised using carbon dioxide laser followed by a medical assessment in the 3rd post-excisional month. FSFI and BDI scales were used on a group of healthy patients with anogenital condyloma at 0-3 months.
Results: There was a statistically significant difference in the FSFI scores at 0 and 3 months between the case and control groups (p<0,001). Although no statistically significant difference was found, a trend of improvement in the FSFI scores of cases from 0 to 3 months was observed (p = 0.194). A statistically significant difference was found in the BDI scores of cases from 0 to 3 months (p = 0.002).
Conclusion: Anogenital condylomas cause negative effects on female psychology and sexuality, and excisional intervention seems to have a beneficial effect on psychology and sexual functions.

Anahtar Kelimeler

HPV, condyloma, sexual functioning, depression

Teşekkür

The authors wish to thank the editors of Model Statistics Center for help with the statistical treatment of the data.

Kaynakça

• Centers for Disease Control and Prevention. Genital HPV infection—CDC fact sheet. Centers for Disease Control and Prevention 2017. https://www.cdc.gov/std/hpv/hpv-Fs-July-2017.pdf
• Münger K, Baldwin A, Edwards KM, et al. Mechanisms of Human Papillomavirus-Induced Oncogenesis. J Virol 2004; 78: 11451–60.
• Melia M. Human papillomavirus (HPV). The Johns Hopkins University, 2017. https: //www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540278/1/Human_papillomavirus__HPV_.
• Gravitt PE, Peyton CL, Apple RJ, Wheeler CM. Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method. J Clin Microbiol 1998; 36: 3020–7.
• Ozgul N, Tuncer M, Abacioglu M, Gultekin M. Estimating prevalence of genital warts in Turkey: Survey among KETEM-affiliated gynecologists across Turkey. Asian Pacific J Cancer Prev 2011; 12: 2397–400.
• Graziottin A, Serafini A. HPV infection in women: Psychosexual impact of genital warts and intraepithelial lesions. J Sex Med 2009; 6: 633–45.
• Morin C, Bouchard C, Brisson J, Fortier M, Blanchette C, Meisels A. Human papillomaviruses and vulvar vestibulitis. Obstet Gynecol 2000; 95: 683–7.
• Aygin D, Eti Aslan F. The Turkish adaptation of the female sexual function index. Turkiye Klin J Med Sci 2005; 25: 393–9.
• Şahin NH. Beck depresyon envanterinin universite ogrencileri icin gecerliligi ve guvenirligi. Psikol Derg 1989; 7: 3–13.
• Parkpinyo N, Chayachinda C, Thamkhantho M. Factors associated with sexual dysfunction in women experiencing anogenital warts at Siriraj hospital. J Med Assoc Thail 2020; 103: 359–64.
• Bruni L, Diaz M, Castellsagué X, Ferrer E, Bosch FX, De Sanjosé S. Cervical human papillomavirus prevalence in 5 continents: Meta-analysis of 1 million women with normal cytological findings. J Infect Dis 2010; 202: 1789–99.
• Waller J, McCaffery K, Kitchener H, Nazroo J, Wardle J. Women’s experiences of repeated HPV testing in the context of cervical cancer screening: A qualitative study. Psychooncology 2007; 16: 196–204.
• Bennett KF, Waller J, Ryan M, Bailey JV, Marlow LAV. Concerns about disclosing a high-risk cervical human papillomavirus (HPV) infection to a sexual partner: A systematic review and thematic synthesis. BMJ Sex Reprod Heal 2019; 47: 17–26.
• Filiberti A, Tamburini M, Stefanon B, et al. Psychological aspects of genital human papillomavirus infection: A preliminary report. J Psychosom Obstet Gynecol 1993; 14: 145–52.
• McCaffery K, Waller J, Forrest S, Cadman L, Szarewski A, Wardle J. Testing positive for human papillomavirus in routine cervical screening: Examination of psychosocial impact. BJOG An Int J Obstet Gynaecol 2004; 111: 1437–43.
• McCaffery K, Waller J, Nazroo J, Wardle J. Social and psychological impact of HPV testing in cervical screening: A qualitative study. Sex Transm Infect 2006; 82: 169–74.
• Nagele E, Reich O, Greimel E, Dorfer M, Haas J, Trutnovsky G. Sexual activity, psychosexual distress, and fear of progression in women with human papillomavirus-related rremalignant genital lesions. J Sex Med 2016; 13: 253–9.
• Özçelik B, Serin IS, Gökahmetoğlu S, Başbuğ M, Erez R. Human papillomavirus frequency of women at low risk of developing cervical cancer: A preliminary study from a Turkish university hospital. Eur J Gynaecol Oncol 2003; 24: 157–9.
• Sakin Ö, Uzun SB, Koyuncu K, Giray B, Akalın EE, Anğın AD. Cervix human papilloma virus positivity: Does it cause sexual dysfunction? J Turkish Soc Obstet Gynecol 2020; 16: 235–41.
• Vriend HJ, Nieuwkerk PT, van der Sande MAB. Impact of genital warts on emotional and sexual well-being differs by gender. Int J STD AIDS 2014; 25: 949–55.
• El-esawy F, Ahmed H. Effect of Genital Warts on Female Sexual Function and Quality of Life: An Egyptian Study. Hum Androl 2017; 7: 58–64.
• Nahidi M, Nahidi Y, Kardan G, et al. Evaluation of Sexual Life and Marital Satisfaction in Patients with Anogenital Wart. Actas Dermosifiliogr 2019; 110: 521–5.
• Scrivener L, Green J, Hetherton J, Brook G. Disclosure of anogenital warts to sexual partners. Sex Transm Infect 2008; 84: 179–82.
• Waller J, Marlow LAV, Wardle J. The association between knowledge of HPV and feelings of stigma, shame and anxiety. Sex Transm Infect 2007; 83: 155–9.
• de Sanjosé S, Diaz M, Castellsagué X, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis 2007; 7: 453–9.
• Kaderli R, Schnüriger B, Brügger LE. The impact of smoking on HPV infection and the development of anogenital warts. Int J Colorectal Dis 2014; 29: 899–908.
• Lam JUH, Rebolj M, Dugué PA, Bonde J, von Euler-Chelpin M, Lynge E. Condom use in prevention of human papillomavirus infections and cervical neoplasia: Systematic review of longitudinal studies. J Med Screen 2014; 21: 38–50.
• Dinh TH, Sternberg M, Dunne EF, Markowitz LE. Genital warts among 18- to 59-year-olds in the United States, National Health and Nutrition Examination Survey, 1999-2004. Sex Transm Dis 2008; 35: 357–60.
• Wiley DJ, Douglas J, Beutner K, et al. External genital warts: Diagnosis, treatment, and prevention. Clin Infect Dis 2002; 35: S210–24.
• Ma J, Kan Y, Zhang A, et al. Female sexual dysfunction in women with non-malignant cervical diseases: A study from an urban Chinese sample. PLoS One 2015; 10: e0141004.
• Ilgen O. Sexual dysfunction in women who are human papillomavirus positive. Reprod Med Gynecol Obstet 2020; 5: 1–4.
• Mercan R, Mercan S, Durmaz B, et al. Sexual dysfunction in women with human papilloma virus infection in the Turkish population. J Obstet Gynaecol (Lahore) 2019; 39: 659–63.
• Uzun SB, Sakin Ö, Hüseyin Ç, Şimsek EE. The effects of HPV test on anxiety, emotion and depression in women. J Acad Res Med 2020; 10: 149–54.