The diagnostic value of calcium binding protein S100A8/A9 and S100A12 in acute pancreatitis

Yıl 2022, Cilt: 5 Sayı: 3, 844 - 849, 30.05.2022

Okan Bardakcı , Murat Daş , Hilal Şehitoğlu , Ece Ünal Çetin , Ünzile Atalay , Uğur Küçük , Fatih Kamış , Alpaslan Tanoğlu , Yavuz Beyazıt

https://doi.org/10.32322/jhsm.1096501

Öz

Background: S100A8/A9 and S100A12 which are the major calcium-binding proinflammatory proteins secreted by granulocytes, has been proposed to be related to distinct disease states of inflammatory origin. This study aims to explore the circulating levels of S100A8/A9 and S100A12 in acute pancreatitis (AP) and reveal their relationship with conventional inflammatory markers.
Material and Method: Serum S100A8/A9 and S100A12 were determined in AP patients (male/female: 17/13) by using a specific enzyme-linked immunosorbent assay (ELISA) method at both onset and remission and in 30 healthy controls (male/female: 17/13).
Results: Significantly higher S100A8/A9 and S100A12 levels were found in AP patients compared to healthy controls (p<0.001). Circulating levels of S100A8/9, S100A12 and C-reactive protein (CRP) were found to be elevated in AP patients at disease onset compared with remission. The correlation analysis demonstrated a significant association between S100A8/A9 and S100A12 (r=0.366, p=0.047). The cut-off level for S100A8/A9 for detecting AP was ≥54.4 ng/ml with a sensitivity and specificity of 96.7% and 73.3% (AUC: 0.958). The optimum cut-off level for S100A12 for detecting AP was ≥350.25 ng/ml with a sensitivity and specificity of 73.3% and 76.7% (AUC: 0.752) respectively.
Conclusion: Circulating S100A8/A9 and S100A12 levels were found to be elevated in AP patients. Both of these markers might serve as an additional tool in the diagnostic workup in AP since S100A8/A9 and S100A12 were significantly correlated with CRP.

Anahtar Kelimeler

Acute pancreatitis, S100A8/A9, S100A12, CRP, inflammation

Proje Numarası

THD-2020-3255

Kaynakça

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