Radiological comparison of the Wuhan and B.1.1.7 variant COVID-19 infection; are there any differences in chest CT scans?

Yıl 2022, Cilt: 5 Sayı: 4, 1009 - 1014, 20.07.2022

Özlem Demircioğlu , Derya Kocakaya , Canan Çimşit , Rabia Can Sarinoğlu , Nurver Ülger , Cagatay Çimşit

https://doi.org/10.32322/jhsm.1114475

Öz

Aim: In September 2020, a variant of the SARS-CoV-2 virus was detected in England and it became the dominant type in most of the countries. The clinical behavior of the B.1.1.7 variant COVID-19 infectionis different from the Wuhan type.So we aimed to investigate whether there are any differences in computed tomography (CT) imaging findings of pneumonia caused by COVID-19 variants.
Material and Method: 340 patients who admitted to the emergency departmentwith symptoms of dyspnea and chest pain suspecting COVID-19 pneumonia and pulmonary embolism were included in the study. Oncology (n:12) and pediatric (n:8) patients, patients with negative PCR test (n:56), and patients infected with different variant (n:6) were excluded leaving 258 patients grouped into two (B.1.1.7 and Wuhan type) for evaluation of CT findings such as pleural thickening,pleural and pericardial effusion, consolidation, GGO presence and distribution, upper lobe involvement, pulmonary embolism, tree in bud pattern, centrilobuler nodule, revers halo sign, and hepatosteatosis.
Results: A statistically significant difference was obtained between the two groups in terms of pleural thickening (p=0.020), upper lobe involvement (p=0.037), localization of GGO (p=0.001), presence of pleural effusion (p=0.025), embolism (p=0.011) and presence of consolidation (p=0.042). However, no significant difference was found for the development of hepatosteatosis (p=0.520).
Conclusion: There aredifferences in radiological findings between B.1.1.7 variant and Wuhan type. In our study atypical radiological findings are more common in B.1.1.7 type. In addition, radiological findings that seen in severe COVID-19 pneumonia are more common in B.1.1.7.

Anahtar Kelimeler

Covid 19, Wuhan type, B.1.1.7 variant, Tomographic differences, Tomography

Kaynakça

• Public Health England, “Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01” (2020); www.gov.uk/ government/publications/investigation-of-novel-sars-cov-2- variant-variant-of-concern-20201201
• Davies NG, Abbott S, Barnard RC, et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science 2021; 372: eabg3055.
• Gu H, Chen Q, Yang G, et al. Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy. Science 2020; 369: 1603-7.
• Starr TN, Greaney AJ, Hilton SK, et al. Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding. Cell 2020; 182: 1295-310.
• Kara U, Şimşek F, Özhan MÖ, et al. The factor analysis approach to mortality prediction in COVID-19 severe disease using laboratory values: a retrospective study. J Health Sci Med 2022; 5: 528-33.
• Mutlu P, Mirici A, Gönlügür U, et al. Evaluating the clinical, radiological, microbiological, biochemical parameters and the treatment response in COVID-19 pneumonia. J Health Sci Med 2022; 5: 544-51.
• Hefeda MM. CT chest findings in patients infected with COVID-19: review of literature. The Egyptian J Radiol Nuclear Med2020; 51: 239.
• Lopez-Mendez I, Aquino-Matus J, Gall SM, et al. Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19). Ann Hepatol 2021; 20: 100271.
• Ceylan N, Çinkooğlu A, Bayraktaroğlu S, Savaş R. Atypical chest CT findings of COVID-19 pneumonia: a pictorial review. Diagn Interv Radiol 2021; 27: 344-9.
• Li M, Lei P, Zeng B, et al. Coronavirus Disease (COVID-19): Spectrum of CT findings and temporal progression of the disease. Acad Radiol 2020; 27: 603-8.
• Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol 2020; 30: 4381-9.
• Pan F, Ye T, Sun P, et al. Time Course of Lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19). Radiology 2020; 295: 715-21.
• Wei J, Xu H, Xiong J, et al. 2019 Novel coronavirus (COVID-19) pneumonia: serial computed tomography findings. Korean J Radiol 2020; 21: 501-4.
• Litmanovich DE, Chung M, Kirkbride RR, Kicska G, Kanne JP. Review of chest radiograph findings of covıd-19 pneumonia and suggested reporting language. J Thorac Imaging 2020; 35: 354-60.
• Li K, Wu J, Wu F, et al. The clinical and chest CT features associated with severe and critical COVID-19 pneumonia. Invest Radiol 2020; 55: 327-31.
• Jevnikar M, Sanchez O, Chocron R, et al. Prevalence of pulmonary embolism in patients with COVID-19 at the time of hospital admission. Eur Respir J 2021; 58: 2100116.
• Díaz LA, Idalsoaga F, Cannistra M, et al. High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data. World J Gastroenterol 2020; 26: 7693-706.
• Medeiros AK, Barbisan CC, Cruz IR, et al. Higher frequency of hepatic steatosis at CT among COVID-19-positive patients. Abdom Radiol (NY) 2020; 45: 2748-54.