Nazal septum deviasyon tipinin sistemik inflamasyon indeksi ve inflamasyonun kan belirteçleri üzerine etkisi

Yıl 2023, Cilt: 6 Sayı: 5, 1069 - 1073, 28.09.2023

Süheyla Kandemir , Gözde Pamuk

https://doi.org/10.32322/jhsm.1343255

Öz

Amaç: Bu çalışmanın amacı, nazal septum deviasyonu (NSD) olan hastalarda inflamasyonun kan belirteçlerindeki değişiklikleri ve sistemik immün inflamatuar indeksi belirlemekti. Ek bir amaç da septum deviasyon tipine göre bulgularda anlamlı bir fark olup olmadığını belirlemekti.
Gereç ve Yöntemler: Bu retrospektif çalışmaya fizik muayene ve BT (NSD grubu) ile NSD tanısı konan 321 hasta ve 101 sağlıklı kontrol dahil edildi. Standart tam kan sayımı yapıldı. Ana kan parametreleri ve ortalama trombosit hacmi (MPV), nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR) ve sistemik immün inflamatuar indeks (SII) kaydedildi. NSD, Dreher sınıflamasına göre 3 tip olarak sınıflandırıldı ve tipler kendi aralarında ve kontrol grubuyla karşılaştırıldı.
Bulgular: Hemoglobin seviyesi, trombosit ve nötrofil sayıları NSD grubunda kontrol grubuna göre anlamlı derecede yüksekti (her biri için P < 0.001). MPV, NLR, PLR ve SII de NSD grubunda anlamlı olarak daha yüksekti (her biri için P < 0.001). Septum deviasyonu derecesi arttıkça enflamasyonun tüm kan belirteçlerinde önemli bir artış oldu (her biri için P < 0.001).
Sonuç: İnflamasyonun kan belirteçleri, NSD'li hastalarda önemli ölçüde yüksektir. Bulgular, SII'nin NSD'li hastalarda inflamasyonu ölçmek için yararlı ve ucuz bir yöntem olduğunu göstermektedir. Septum deviasyonunun derecesi inflamasyonun derecesini etkileyebilir.

Anahtar Kelimeler

Nazal Septum, Nazal Obstrüksiyon, Ortalama Trombosit Hacmi

Destekleyen Kurum

Yok

Proje Numarası

Yok

The effect of nasal septum deviation type on the systemic inflammatory index and blood markers of inflammation

Öz

Aims: The aim of this study was to identify the changes in blood markers of inflammation and the systemic immune inflammatory index in patients with nasal septum deviation (NSD). An additional aim was to determine if there was a significant difference in the findings according to septum deviation type.
Methods: This retrospective study included 321 patients diagnosed with NSD via physical examination and CT (NSD group), and 101 healthy controls. Standard complete blood count was performed. Main blood parameters and mean platelet volume (MPV), the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune inflammatory index (SII) were recorded. NSD was classified as 3 types according to Dreher classification, and the types were compared to each other and the control group.
Results: The hemoglobin level, and platelet and neutrophil counts were significantly higher in the NSD group than in the control group (P<0.001 for each). The MPV, NLR, PLR, and SII were also significantly higher in the NSD group (P<0.001 for each). There was a significant increase in all blood markers of inflammation as the degree of septum deviation increased (P<0.001 for each).
Conclusion: Blood markers of inflammation are significantly elevated in patients with NSD. The SII value can indicate an inflammatory condition in these patients. The degree of septum deviation can affect the degree of inflammation.

Anahtar Kelimeler

Nasal septum, nasal obstruction, mean platelet volume

Proje Numarası

Yok

Kaynakça

• Sagit M, Korkmaz F, Kavugudurmaz M, Somdas MA. Impact of septoplasty on mean platelet volume levels in patients with marked nasal septal deviation. J Craniofac Surg. 2012;23:974-6.
• Avcı D, Hartoka Sevinç A, Güler S. The systolic pulmonary artery pressure and the E/e' ratio decrease after septoplasty in patients with grade 2 and 3 pure nasal septal deviation. Braz J Otorhinolaryngol. 2021;87:497-504.
• Ulu S, Ulu MS, Bucak A, Kahveci OK, Yucedag F, Aycicek A. Evaluating the relationship between nasal obstruction and mean platelet volume by using acoustic rhinometry in patients with septum deviation. Rhinology. 2013;51:249-52.
• Varol E, Ozturk O, Gonca T, et al. Mean platelet volume is increased in patients with severe obstructive sleep apnea. Scand J Clin Lab Invest. 2010;70:497-502.
• Kökoğlu K, Şahin MI. Use of neutrophil, eosinophil, basophil, and platelet to lymphocyte ratio to predict patient satisfaction after septoplasty plus inferior turbinate reduction. J Craniofac Surg. 2019;30:1022-6.
• Candemir M, Kiziltunç E, Nurkoç S, Şahinarslan A. Relationship between systemic immune-inflammation index (SII) and the severity of stable coronary artery disease. Angiology. 2021;72:575-81.
• Dreher A, de la Chaux R, Klemens C, et al. Correlation between otorhinolaryngologic evaluation and severity of obstructive sleep apnea syndrome in snorers. Arch Otolaryngol Head Neck Surg. 2005;131:95-8.
• Alghamdi FS, Albogami D, Alsurayhi AS, et al. Nasal septal deviation: a comprehensive narrative review. Cureus. 2022;14:31317.
• Unlu I, Kesici GG, Oneç B, Yaman H, Guclu E. The effect of duration of nasal obstruction on mean platelet volume in patients with marked nasal septal deviation. Eur Arch Otorhinolaryngol. 2016;273:401-5.
• Kara A, Guven M, Yilmaz MS, Demir D, Elden H. Are neutrophil, platelet and eosinophil-to- lymphocyte ratio and red blood cell distribution width can be used for nasal polyposis? Eur Arch Otorhinolaryngol. 2018;275:409-13.
• Karataş M, Taşolar H. The effect of marked nasal septal deviation on left ventricular function and blood markers. J Craniofac Surg. 2019;30:803-7.
• Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20:6212-22.
• Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of systemic immune-inflammation index in cancer: a meta-analysis. J Cancer. 2018;9:3295-302.
• Zhong JH, Huang DH, Chen ZY. Prognostic role of systemic immune-inflammation index in solid tumors: a systematic review and meta-analysis. Oncotarget. 2017;8:75381-8.
• Kubota K, Ito R, Narita N, Tanaka Y, et al. Utility of prognostic nutritional index and systemic immune-inflammation index in oral cancer treatment. BMC Cancer. 2022;22:368.
• Kınar A, Ulu Ş, Bucak A, Kazan E. Can Systemic Immune-Inflammation Index (SII) be a prognostic factor of Bell's palsy patients? Neurol Sci. 2021;42:3197-201.
• Yıldız E, Kuzu S, Günebakan Ç, Balcı A. A new biomarker in differentiation of mucosal chronic otitis media from squamous chronic otitis media: the systemic immune-inflammation index (SII). Indian J Otolaryngol Head Neck Surg. 2022;74:476-82.