Distribution of ABO and Rh blood groups in gynecological cancer cases

Yıl 2024, Cilt: 7 Sayı: 1, 126 - 131, 15.01.2024

Ramazan Adan , Veli Mihmanlı

https://doi.org/10.32322/jhsm.1404257

Öz

Aims: To investigate the relationship between blood type and gynecological cancers (ovarian, endometrial, and cervical).
Methods: In the study, between 2017 and 2022, 457 patient files who underwent surgery for gynecological cancer at İstanbul Prof. Dr. Cemil Taşçıoğlu City Hospital were reviewed. Seventy-eight of these files were excluded from the study due to missing data. Out of the remaining files, 379 were considered suitable for the study. Twenty-five of these were further excluded due to being cases of other gynecological cancers. A total of 354 patients were included in the study (n=354). Participants' sociodemographic data such as age and gender, cancer type, and blood groups (ABO-Rh) were retrospectively collected from patient records and the hospital automation system. Cases with missing data or inaccessible sociodemographic records were excluded from the study. The study was planned retrospectively and observationally. Gynecological cancers were examined in the three most common groups: ovarian cancer, endometrial cancer, and cervical cancer. The patients' blood group, Rh status, and pathology reports were analyzed. Based on the pathological diagnosis, three groups were initially formed, and below them, Rh and blood group status were noted. The blood group and Rh status in cancer groups were first presented in numbers and then calculated as percentages.
Results: The AB+ ratio in cervical cancers was statistically significantly higher compared to the reference article and endometrial cancers (p=0.021, p=0.049).
Conclusion: There are studies indicating a significant relationship between blood groups and various diseases. The expression of blood group antigens on blood cells and other epithelial surfaces acting as receptors or signal transducers contributes to these findings. The possibility of ABO antigens serving as receptors in tumor structures caused by infections, such as cervical cancer, should not be overlooked. In this regard, the significantly higher prevalence of cervical cancer in individuals with AB Rh (+) blood type, carrying A, B, and Rh antigens, can be explained concerning the population.

Anahtar Kelimeler

Gynecological cancers, Blood group, Cervical cancers

Etik Beyan

The study was initiated with the approval of the Prof. Dr. Cemil Taşcıolu City Hospital Clinical Researches Ethics Committee (Date:26.12.2022, Decision No:366).

Destekleyen Kurum

none

Teşekkür

none

Kaynakça

• Weissinger M, Kommoss S, Jacoby J, et al. Multiparametric dual-time-point [18F] FDG PET/MRI for lymph node staging in patients with untreated FIGO I/II cervical carcinoma. J Clin Med. 2022;11(17):4943.
• Wright JD, Matsuo K, Huang Y, et al. Prognostic performance of the 2018 International Federation of Gynecology and Obstetrics Cervical Cancer Staging Guidelines. Obstet Gynecol. 2019;134(1):49.
• Berek JS, Matias-Guiu X, Creutzberg C, et al. FIGO staging of endometrial cancer: 2023. Int J Gynaecol Obstet. 2023;162:383.
• Torre LA, Trabert B, DeSantis CE, et al. Ovarian cancer statistics, 2018. CA Cancer J Clin. 2018;68(4):284.
• Şahin F, Aydın E, Öcal EU, et al. Evaluation of colposcopy and LEEP results performed in gynecology and gynecological oncology surgery services. Eur J Gynaecol Oncol. 2024. doi:10.22514/ejgo.2023.071
• Yamamoto F, Cid E, Yamamoto M, et al. ABO research in the modern genomics era. Transfusion Med Rev. 2012;26(2):103-118.
• Canan E. İstanbul ilinde ABO ve Rh kan grupları dağılımının analizi. Dicle Tıp Derg. 2019;46(2):241-246.
• Lin S, Cao Y, Zhu K, et al. Identification of a novel prognostic signature based on N-linked glycosylation and its correlation with immunotherapy response in hepatocellular carcinoma. J Hepatocell Carcinoma. 2023;10:1749-1765.
• Thakur SK, Sompal S, Dinesh Kumar N, et al. Link between human ABO blood groups with diseases influencing blood donors and recipients frequency at RBTC, Delhi, India. Bioinformation. 2023;19(5):576-581.
• Cozzi GD, Levinson RT, Toole H, et al. Blood type, ABO genetic variants, and ovarian cancer survival. PLoS One. 2017;12(4):e0175119.
• Marinaccio M, Traversa A, Carioggia E, et al. Blood groups of the ABO system and survival in gynecological tumors. Minerva Ginecol. 1995;47(3):69-76.
• Kai LJ, Raju K, Lingaiah HKM, et al. Importance of blood type and social factors in carcinoma cervix in a semi-urban population in India. Asian Pac J Cancer Prev. 2013;14(8):4811-4814.
• Fotra R, Upma U, Gupta S, et al. Association of ABO and Rh blood groups with the carcinoma of the cervix with special reference to Jammu region. Biosci Biotech Res Asia. 2011;8(1):313-316.
• Hanprasertpong J, Jiamset I. Atjimakul T. Prognostic value of ABO blood group in patients with early stage cervical cancer treated with radical hysterectomy with pelvic node dissection. Tumor Biol. 2016;37(6):7421-7430
• Tyagi SP, Tiagi GK, Pradhan S. ABO blood grops in relation to cancer cervix. Indian J Med Sci. 1967;21:611-615.
• Vaillant AJ, Bazuaye P, McFarlane-Anderson N, et al. Association between ABO blood type and cervical dysplasia/carcinoma in Jamaican women. Brit J Med Med Res. 2013;28;3(4):2017-2021.
• Razzaghi N, Seraj H, Heydari K, et al. ABO blood groups associations with ovarian cancer: a systematic review and meta-analysis. Indian J Gynecol Oncolog. 2020;18(4):112.
• Seebacher V, Polterauer S, Reinthaller A, et al. AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer - a retrospective multicenter study. BMC Cancer. 2018;18(1):447.
• Song Q, Wu JZ, Wang S, Chen ZB. ABO blood type is an independent prognostic factor in ovarian cancer patients. J Cancer. 2019;10(26):6754-6760.
• Xu WH, Zheng W, Xiang YB, et al. ABO blood type is associated with endometrial cancer risk in Chinese women. Chin J Cancer. 2011;30(11):766-771.
• Mandato VD, Torricelli F, Mastrofilippo V, et al. Prognostic impact of ABO blood group on type I endometrial cancer patients- results from our own and other studies. J Cancer. 2017;8(14):2828-2835.
• Gitas G, Proppe L, Alkatout I, et al. Is ABO blood group a risk or prognostic factor for patients with endometrioid endometrial cancer? a retrospective analysis in Germany. Blood Transfus. 2020;18(6):465-470.
• Şahin F, Odacılar AŞ, Günkaya OS, et al. Is neutrophil lymphocyte ratio magic or not? J Health Sci Med. 2023;6(3):618-622.
• Raev SA, Raque M, Kick MK, Saif LJ, Vlasova AN. Differential transcriptome response following infection of porcine ileal enteroids with species A and C rotaviruses. Virol J. 2023;20(1):238.
• Teuwen LA, Geldhof V, Pasut A, et al. COVID-19: vascular system released. Nature Rev Immunol. 2020;20(7):389-391.
• Abegaz SB. Human ABO blood groups and their associations with different diseases. Biomed Res Int. 2021;2021:6629060.