Protective effects of curcumin and quercetin in studies on cancer; a meta-analysis study

Yıl 2024, Cilt: 7 Sayı: 3, 314 - 320, 27.05.2024

Buket Akcan Altınkaynak , Yahya Altınkaynak

https://doi.org/10.32322/jhsm.1454820

Öz

Aims: Polyphenolic chemicals, such as quercetin and curcumin have anti-cancer properties due to their antioxidant and anti-inflammatory properties. Quercetin and curcumin aids in detoxification by boosting enzyme function and eliminating free radicals. We aimed to conduct a detailed meta-analysis of research articles reporting the protective effects of curcumin and quercetin in cancer studies.
Methods: The study was selected all studies over time carried out to date within the framework of our concept ,using various medical subject headings and databases like Elsevier, National Library of Frontiers, ResearchGate, Scopus Medicine, and Google Scholar. PRISMA guidelines was performed. The data management system played a significant role in locating and evaluating relevant articles, ensuring the accuracy and precision of the findings.
Results: From a total of 85 articles accessed in this analysis, 4 studies on quercetin and 3 studies on curcumin were included. The analyzed studies show that quercetin and curcumin have anti-cancer benefits through various cellular pathways. Quercetin inhibits Twist in breast cancer cells, while curcumin reduces Akt/mTOR cellular signaling, enhances Bax expression, and triggers cell death. It also prevents cell growth in human lung cancer cells and bladder cancer. Curcumin control reactive oxygen species levels, inhibit cancer cell proliferation, and stimulate apoptotic pathways. They also influence cancer development by altering cellular signaling pathways and affecting non-coding RNAs.
Conclusion: Our meta-analysis reports that quercetin and curcumin have the potential to be used in the treatment and prevention of cancer, it may be useful to investigate their synergistic effects.

Anahtar Kelimeler

antioxidants, cancer, dietary intervention, functional food

Etik Beyan

This material is the authors' own original work, which has not been previously published elsewhere.

Destekleyen Kurum

None

Proje Numarası

None

Teşekkür

None

Kaynakça

• Abbas M, Saeed F, Anjum FM, et al. Natural polyphenols: an overview. Int J Food Prop. 2017;20(8):1689-1699. doi: 10.1080/10942912.2016.1220393
• Mancini-Filho J. Bioavailability of phenolic compounds in food and their properties in cellular protection. Bioequiv Bioavailab Int J. 2020;4(1):000145. doi: 10.23880/beba-16000145
• Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270-278. doi: 10.4161/oxim.2.5.9498
• Scalbert A, Manach C, Morand C, Rémésy C, Jiménez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr. 2005;45(4):287-306. doi: 10.1080/1040869059096
• Slika H, Mansour H, Wehbe N, et al. Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms. Biomed Pharmacother. 2022;146:112442. doi: 10.1016/j.biopha.2021.112442
• León-González AJ, Auger C, Schini-Kerth VB. Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy. Biochem Pharmacol. 2015; 98(3):371-380. doi: 10.1016/j.bcp.2015.07.017
• Cione E, Torre C La, Cannataro R, Caroleo MC, Plastina P, Gallelli L. Quercetin, epigallocatechin gallate, curcumin, and resveratrol: from dietary sources to human microRNA modulation. Molecules. 2020;25(1):63. doi: 10.3390/molecules25010063
• Batiha GE, Beshbishy AM, Ikram M, et al. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods. 2020; 9(3):374. doi: 10.3390/foods9030374
• Lakhanpal P, Rai DK. Quercetin: a versatile flavonoid. Int J Med Update. 2007;2(2):22-37. doi: 10.4314/ijmu.v2i2.39851
• Tang SM, Deng XT, Zhou J, Li QP, Ge XX, Miao L. Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomed Pharmacother. 2020;121:109604. doi: 10.1016/j.biopha.2019.109604
• Shafabakhsh R, Asemi Z. Quercetin: a natural compound for ovarian cancer treatment. J Ovarian Res. 2019;12(1):55. doi: 10.1186/s13048-019-0530-4
• Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – a review. J Tradit Complement Med. 2017;7(2):205-233. doi: 10.1016/j.jtcme.2016.05.005
• Katsuyama Y, Kita T, Funa N, Horinouchi S. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J Biologic Chem. 2009;284(17):11160-11170. doi: 10.1074/jbc.M900070200
• Naama JH, Alwan GH, Obayes HR, et al. Curcuminoids as antioxidants and theoretical study of stability of curcumin isomers in gaseous state. Res Chemic Intermediat. 2013;39(9):4047-4059. doi: 10.1007/s11164-012-0921-2
• Cháirez-Ramírez MH, de la Cruz-López KG, García-Carrancá A. Polyphenols as antitumor agents targeting key players in cancer-driving signaling pathways. Front Pharmacol. 2021;12:710304. doi: 10.3389/fphar.2021.710304
• Wang H, Zhang K, Liu J, et al. Curcumin regulates cancer progression: focus on ncRNAs and molecular signaling pathways. Front Oncol. 2021;11:660712. doi: 10.3389/fonc.2021.660712
• Khan H, Reale M, Ullah H, et al. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions. Biotechnol Adv. 2020;38:107385. doi: 10.1016/j.biotechadv.2019.04.007
• Hasan AA, Tatarskiy V, Kalinina E. Synthetic pathways and the therapeutic potential of quercetin and curcumin. Int J Mol Sci. 2022;23(22):14413. doi: 10.3390/ijms232214413
• Desmoulin A, Joly E, Tran P, Derancourt C, Bertolotti A. Methodological quality of systematic reviews of the local management of anogenital warts: a systematic review using AMSTAR II, ROBIS and PRISMA. Sex Transm Infect. 2023; 99(5):345-347. doi: 10.1136/sextrans-2023-055796
• Ranganathan S, Halagowder D, Sivasithambaram ND. Quercetin suppresses twist to induce apoptosis in MCF-7 breast cancer cells. PLoS One. 2015;10(10):e0141370. doi: 10.1371/journal.pone.0141370
• Hu S, Xu Y, Meng L, Huang L, Sun H. Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. Exp Ther Med. 2018;16(2):1266-1272. doi: 10.3892/etm.2018.6345
• Catanzaro D, Ragazzi E, Vianello C, Caparrotta L, Montopoli M. Effect of quercetin on cell cycle and cyclin expression in ovarian carcinoma and osteosarcoma cell lines. Nat Prod Commun. 2015;10(8):1365-1368. doi: 10.1177/1934578x1501000813
• Yu Z, Wan Y, Liu Y, Yang J, Li L, Zhang W. Curcumin induced apoptosis via PI3K/Akt-signalling pathways in SKOV3 cells. Pharm Biol. 2016;54(10):2026-2032. doi: 10.3109/13880209.2016.1139601
• Yang L, Liu Y, Wang M, et al. Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Mol Med Rep. 2016;14(5):4559-4566. doi: 10.3892/mmr.2016.5818
• Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P, Goel A. Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways. PLoS One. 2013;8(2):e57218. doi: 10.1371/journal.pone.0057218
• Mo F, Xiao Y, Zeng H, et al. Curcumin-induced global profiling of transcriptomes in small cell lung cancer cells. Front Cell Dev Biol. 2021;8:588299. doi: 10.3389/fcell.2020.588299
• Tsai TF, Hwang TIS, Lin JF, et al. Suppression of quercetin-induced autophagy enhances cytotoxicity through elevating apoptotic cell death in human bladder cancer cells. Urol Sci. 2019;30(2):58-66. doi: 10.4103/UROS.UROS_22_18
• Zhaorigetu, Farrag IM, Belal A, et al. Antiproliferative, apoptotic effects and suppression of oxidative stress of quercetin against induced toxicity in lung cancer cells of rats: In vitro and in vivo study. J Cancer. 2021;12(17):5249. doi: 10.7150/jca.52088
• Tsiailanis AD, Renziehausen A, Kiriakidi S, et al. Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid. Free Radic Biol Med. 2020;160:391-402. doi: 10.1016/j.freeradbiomed.2020.08.007
• Luo SM, Wu YP, Huang LC, Huang SM, Hueng DY. The anti-cancer effect of four curcumin analogues on human glioma cells. Onco Targets Ther. 2021;14:4345-4359. doi: 10.2147/OTT.S313961
• Zhou H, Ning Y, Zeng G, Zhou C, Ding X. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncol Rep. 2021;45(4):11. doi: 10.3892/or.2021.7962
• Grillone K, Riillo C, Scionti F, et al. Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter”. J Exper Clin Cancer Res. 2020;39(1):117. doi: 10.1186/s13046-020-01622-x
• Yi J, Li S, Wang C, et al. Potential applications of polyphenols on main ncRNAs regulations as novel therapeutic strategy for cancer. Biomed Pharmacother. 2019;113:108703. doi: 10.1016/j.biopha.2019.108703
• Liu H, Lei C, He Q, Pan Z, Xiao D, Tao Y. Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018;17(1):64. doi: 10.1186/s12943-018-0765-5
• Winkle M, El-Daly SM, Fabbri M, Calin GA. Noncoding RNA therapeutics — challenges and potential solutions. Nat Rev Drug Discov. 2021;20(8):629-651. doi: 10.1038/s41573-021-00219-z
• Nwaeburu CC, Bauer N, Zhao Z, et al. Up-regulation of microRNA Let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. Oncotarget. 2016;7(36):58367-58380. doi: 10.18632/oncotarget.11122
• Sohn EJ, Bak KM, Nam YK, Park HT. Upregulation of microRNA 344a-3p is involved in curcumin induced apoptosis in RT4 schwannoma cells. Cancer Cell Int. 2018;18(1):199. doi: 10.1186/s12935-018-0693-x
• Pan L, Sha J, Lin W, Wang Y, Bian T. Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis. Exp Ther Med. 2021;22(3):969. doi: 10.3892/etm.2021.10401
• Xu W, Xie S, Chen X, Pan S, Qian H, Zhu X. Effects of quercetin on the efficacy of various chemotherapeutic drugs in cervical cancer cells. Drug Des Devel Ther. 2021;15:577-588. doi: 10.2147/DDDT.S291865
• Shen H, Shen J, Pan H, et al. Curcumin analog B14 has high bioavailability and enhances the effect of anti-breast cancer cells in vitro and in vivo. Cancer Sci. 2021;112(2):815-827. doi: 10.1111/cas.14770
• Suh DK, Lee EJ, Kim HC, Kim JH. Induction of G1/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. Arch Pharm Res. 2010;33(5):781-785. doi: 10.1007/s12272-010-0519-4