Behçet hastalığı olan kadınlarda gebelik sonuçları

Yıl 2025, Cilt: 8 Sayı: 6, 1182 - 1186, 25.10.2025

Erhan Muluk

https://doi.org/10.32322/jhsm.1788976

Öz

Amaçlar: Son 30 yılda yayınlanmış olgu sunumlarının birleştirilmiş analizine dayanarak, Behçet hastalığı (BH) ile komplike gebeliklerin maternal ve neonatal sonuçlarını tanımlamak.
Yöntemler: Ocak 1995 ile Mart 2025 arasında yayınlanmış gebelikte BH olgu sunumlarını ve olgu serilerini belirlemek için PubMed, Web of Science Core Collection ve Google Akademik'te sistematik bir arama yapıldı. Anne yaşı, hastalık süresi, hastalık aktivitesi, doğum sonuçları ve yenidoğan doğum ağırlığına ilişkin veriler çıkarıldı.
Bulgular: Toplam 61 olgu tespit edildi. Ortalama anne yaşı 32,3 ± 6,3 yıl ve ortalama hastalık süresi 5,2 ± 3,2 yıldı. Gebelik sırasında alevlenmeler kadınların %32,8'inde bildirildi. Preterm doğum (%11,5) ve düşük doğum ağırlığı (%11,5) en sık görülen komplikasyonlar iken, düşük (%3,3) ve preeklampsi (%1,6) daha az sıklıkta görüldü. Ortalama yenidoğan doğum ağırlığı 3045 ± 517 g olarak bulundu.
Sonuç: Bu birleşik analizde, erken doğum ve düşük doğum ağırlığı, Behçet Hastalığı (BH) olan gebeliklerde en sık görülen komplikasyonlardı. Kadın doğum uzmanları, Behçet Hastalığı'nın (BH) ilk olarak gebelik sırasında ortaya çıkabileceğinin farkında olmalı ve özellikle yüksek prevalanslı bölgelerde etkilenen kadınları yakından takip etmelidir.

Anahtar Kelimeler

Behçet hastalığı , gebelik , erken doğum , düşük doğum ağırlığı , vaskülit

Etik Beyan

Uygun değildir, çünkü bu çalışma yayınlanmış vaka raporlarının incelenmesine dayanmaktadır ve doğrudan hasta alımını içermemektedir.

Destekleyen Kurum

Yazar bu çalışmanın herhangi bir finansal destek almadığını beyan etmiştir.

Teşekkür

Yazar, dolaylı olarak katkıda bulunan tüm meslektaşlarına teşekkür eder.

Pregnancy outcomes in women with Behçet’s disease

Öz

Aims: To describe maternal and neonatal outcomes of pregnancies complicated by Behçet’s disease (BD) based on a pooled analysis of published case reports over the past 30 years.
Methods: A systematic search of PubMed, Web of Science Core Collection, and Google Scholar was performed to identify case reports and case series of BD in pregnancy published between January 1995 and March 2025. Data on maternal age, disease duration, disease activity, delivery outcomes, and neonatal birth weight were extracted.
Results: A total of 61 cases were identified. The mean maternal age was 32.3±6.3 years, and the mean disease duration was 5.2±3.2 years. Flares during pregnancy were reported in 32.8% of women. Preterm delivery (11.5%) and low birth weight (11.5%) were the most common complications, while miscarriage (3.3%) and preeclampsia (1.6%) were less frequent. The mean neonatal birth weight was 3045±517 g.
Conclusion: In this pooled analysis, preterm delivery and low birth weight were the most frequent complications among pregnancies with BD. Obstetricians should be aware that BD may first present during pregnancy and should closely monitor affected women, especially in high-prevalence regions.

Anahtar Kelimeler

Behçet’s disease , pregnancy , preterm birth , low birth weight , vasculitis

Etik Beyan

Not applicable, as this study is based on a review of published case reports and did not involve direct patient recruitment.

Destekleyen Kurum

The author declared that this study has received no finnacial support.

Teşekkür

The author thanks all colleagues who contributed indirectly.

Kaynakça

• Hatemi G, Uçar D, Uygunoğlu U, Yazici H, Yazici Y. Behçet syndrome. Rheum Dis Clin North Am. 2023;49(3):585-602. doi:10.1016/j.rdc.2023. 03.010
• Emmi G, Bettiol A, Hatemi G, Prisco D. Behçet’s syndrome. Lancet. 2024;403(10431):1093-1108. doi:10.1016/S0140-6736(23)02629-6
• Merlino L, Del Prete F, Lobozzo B, Priori R, Piccioni MG. Behcet’s disease and pregnancy: a systematic review. Minerva Ginecol. 2020;72(5):332-338. doi:10.23736/S0026-4784.20.04564-5
• Jadaon J, Shushan A, Ezra Y, Sela HY, Ozcan C, Rojansky N. Behçet’s disease and pregnancy. Acta Obstet Gynecol Scand. 2005;84(10):939-944. doi:10.1111/j.0001-6349.2005.00761.x
• Ben-Chetrit E. Behçet’s syndrome and pregnancy: course of the disease and pregnancy outcome. Clin Exp Rheumatol. 2014;32(4 Suppl 84):S93-98.
• Davatchi F, Chams-Davatchi C, Shams H, et al. Behcet’s disease: epidemiology, clinical manifestations, and diagnosis. Expert Rev Clin Immunol. 2017;13(1):57-65. doi:10.1080/1744666X.2016.1205486
• Maldini C, Druce K, Basu N, LaValley MP, Mahr A. Exploring the variability in Behçet’s disease prevalence: a meta-analytical approach. Rheumatology (Oxford). 2018;57(1):185-195. doi:10.1093/rheumatology/kew486
• Takayama K, Ishikawa S, Enoki T, Kojima T, Takeuchi M. Successful treatment with infliximab for Behçet disease during pregnancy. Ocul Immunol Inflamm. 2013;21(4):321-323. doi:10.3109/09273948.2013.781655
• Fujikawa K, Endo Y, Mizokami A, et al. Successful Treatment with Adalimumab for Intestinal Behcet’s disease during Pregnancy. Intern Med. 2016;55(10):1375-1378. doi:10.2169/internalmedicine.55.6590
• Mainini G, Di Donna MC, Esposito E, et al. Pregnancy management in Behçet’s disease treated with uninterrupted infliximab. Report of a case with fetal growth restriction and mini-review of the literature. Clin Exp Obstet Gynecol. 2014;41(2):205-207.
• Li X, Huang X, Yu X. Behçet’s disease in pregnancy: a case report and literature review. BMC Pregnancy Childbirth. 2025;25(1):69. doi:10.1186/s12884-024-07063-0
• Gomes V, Mesquita A, Capela C. Autoimmune diseases and pregnancy: analysis of a series of cases. BMC Res Notes. 2015;8:216. doi:10.1186/s13104-015-1177-x
• Buntrock A, McNamara M, Tantoush H, Von Wald T. Worsening of Behcet syndrome symptoms during pregnancy. S D Med. 2021;74(3):112-114.
• Fotaki P, Deligeoroglou E, Michailidis E, et al. Adamantiades-Behcet’s syndrome and pregnancy: a case report. Akush Ginekol (Sofiia). 2002; 42(1):38-39.
• Mirfeizi Z, Memar B, PourZand H, Molseghi MH, Rezaei Shahmirzadi A, Abdolahi N. Ventricular endomyocardial fibrosis in a pregnant female with Behçet’s disease. Asian Cardiovasc Thorac Ann. 2018;26(8):619-621. doi:10.1177/0218492316687177
• Nishii S, Yamaguchi K, Amita M, Saito T, Saito H, Sekizawa A. Successful pregnancy in a case of Behçet’s disease after treatment with prednisolone. Case Rep Obstet Gynecol. 2020;2020:8862651. doi:10.1155/ 2020/8862651
• Guzelian G, Norton ME. Behçet’s syndrome associated with intrauterine growth restriction: a case report and review of the literature. J Perinatol. 1997;17(4):318-320.
• Xie L, Benson T, Morgan EE, et al. New onset Behçet’s disease in repeat pregnancy. JAAD Case Rep. 2025;58:106-108. doi:10.1016/j.jdcr. 2024.10.040
• Kale A, Akyildiz L, Akdeniz N, Kale E. Pregnancy complicated by superior vena cava thrombosis and pulmonary embolism in a patient with Behcet disease and the use of heparin for treatment. Saudi Med J. 2006;27(1):95-97.
• Wechsler B, Généreau T, Biousse V, et al. Pregnancy complicated by cerebral venous thrombosis in Behçet’s disease. Am J Obstet Gynecol. 1995;173(5):1627-1629. doi:10.1016/0002-9378(95)90663-0
• Cakal B, Koklu S, Beyazit Y, Ozdemir A, Beyazit F, Ulker A. Fatal colonic perforation in a pregnant with Behçet’s disease. J Crohns Colitis. 2011;5(3):273-274. doi:10.1016/j.crohns.2011.03.003
• Duran B, Şalk S, Erden O, Çetin M, Demirköprülü N. Vulvar oedema associated with Behçet’s disease in pregnancy: a case report. Turkiye Klinikleri J Gynecol Obst. 2003;13(6):463-465.
• Shimada H, Wakiya R, Nakashima S, et al. Clinical courses and pregnancy outcomes of twelve cases complicated with Behcet’s disease in our institution. Ann Rheum Dis. 2023;82(Suppl 1):1974. doi:10.1136/annrheumdis-2023-eular.5190
• Demir O, Ömeroğlu Demir G. Behçet’s disease diagnosed with a multidisciplinary approach in pregnancy. Bezmialem Science. 2025; 13(1):81-83. doi:10.14235/bas.galenos.2024.81904
• Erenel H, Alıcı Davutoğlu E, Özel A, Karslı F, Korkmaz SÖ, Madazlı R. Behçet’s disease and pregnancy: obstetric outcomes of 33 patients. Sisli Etfal Hastan Tip Bul. 2017;51(4):318-321. doi:10.5350/SEMB.201707250 42231
• Lee S, Czuzoj-Shulman N, Abenhaim HA. Behcet’s disease and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 12 million births. J Perinat Med. 2019;47(4):381-387. doi:10. 1515/jpm-2018-0161
• Machen L, Clowse ME. Vasculitis and pregnancy. Rheum Dis Clin North Am. 2017;43(2):239-247. doi:10.1016/j.rdc.2016.12.005
• Orgul G, Aktoz F, Beksac MS. Behcet’s disease and pregnancy: what to expect? J Obstet Gynaecol. 2018;38(2):185-188. doi:10.1080/01443615.2017.1336614
• Doria A, Iaccarino L, Ghirardello A, et al. Pregnancy in rare autoimmune rheumatic diseases: UCTD, MCTD, myositis, systemic vasculitis and Behcet’s disease. Lupus. 2004;13(9):690-695. doi:10.1191/ 0961203304lu1098oa
• Pagnoux C. Pregnancy and vasculitides. Presse Med. 2008;37(11):1657-1665. doi:10.1016/j.lpm.2008.06.016