Doğal Bebek Bezi Pişiği (Bebek Bezi Dermatidi) Krem Formülasyonlarının Geliştirilmesi ve Mikrobiyolojik Değerlendirilmesi

Öz

Amaç: Gül ürünleri üretim tesislerinde atık olarak çevreye salınan Rosa damascena Mill, antioksidan, antimikrobiyal ve antiseptik fenolik bileşenler içermektedir. Gül posasının antimikrobiyal özelliklerinden yararlanılarak ve doğal bileşenler (çinko oksit ZnO, doğal yağlar ve balmumu) eklenerek bebek pişikleri için etkili bir doğal krem formülasyonunun geliştirilmesidir. Gereç ve Yöntem: Pişik kremi formülasyonlarını hazırlamak için emülsifikasyon yöntemi kullanılmıştır. Formülasyonların reolojik davranışını incelemek için rotasyonel tip viskozite tayini yapılmıştır. Optimum formülasyonun seçiminde pH, viskozite, hidrofilik-lipofilik denge ve ürünün fiziksel görünümü dikkate alınmıştır. Stabilite özelliklerini incelemek için, ICH direktifleri doğrultusunda üç farklı ortamda 6 ay boyunca stabilitesi incelenmiştir. Optimum DR-C-7 formülasyonu fizikokimyasal ve stabilite testlerine tabi tutulmuştur. Bulgular: Reolojik özellikler açısından DR-C-7 formülasyonunun 9,820 ile 26,130 (Pa.s) arasında bir viskoziteye sahip olduğu gözlenmiştir. Zorlama testi sonucunda herhangi bir mikrobiyolojik birime rastlanmamıştır. Farklı koşullar altında yapılan 6 aylık stabilite çalışması sonunda tüm özelliklerini koruduğu gözlenmiştir. Sonuç: Feniletil alkol, flavonoidler ve terpenoidler gibi önemli fenolik içeriklere sahip olan R. damascena pulpunun antioksidan antimikrobiyal özellikleri ile pişik kremi gibi kalın ürünlerde kullanılabileceği sonucuna varılmıştır.

Anahtar Kelimeler

• Dermokozmetik
• Rose Damescana Pulpası
• Pişik
• Emülsiyon
• Mikrobiyolojik Analiz

Development and Microbiological Evaluation of Natural Diaper Rash (Diaper Dermatitis) Cream Formulations

Öz

Backround: Rosa damascena Mill, released into the environment as waste in rose products production facilities, contains antioxidant, antimicrobial, and antiseptic phenolic components. It is the development of an effective natural cream formulation for baby diaper rash by taking advantage of the antimicrobial properties of rose pulp and adding natural ingredients (zinc oxide ZnO, natural oils, and beeswax). Material and Methods: The emulsification method was used to prepare diaper rash cream formulations. Rotational type viscosity determination was performed to examine the rheological behavior of the formulations. In selecting the optimum formulation, pH, viscosity, hydrophilic-lipophilic balance, and physical appearance of the product were considered. To examine its stability properties, its stability was examined in three different environments in line with ICH directives for 6months. The optimum DR-C-7 formulation was subjected to physicochemical and stability tests. Results: It was observed that the DR-C-7 formulation had a viscosity between 9,820 and 26,130 (Pa.s) in terms of rheological properties. As a result of the challenge test, no microbiological units were found. At the end of a 6-month stability study under different conditions, it was observed that it retained all its features. Conclusion: It was concluded that R. damascena pulp, which has important phenolic contents such as phenylethyl alcohol, flavonoids, and terpenoids, can be used for thick products such as diaper rash cream with its antioxidant antimicrobial properties.

Anahtar Kelimeler

• Dermocosmetics
• Rose Damescana Pulp
• Baby Rash
• Emulsion
• Microbiological Analysis

Destekleyen Kurum

No

Etik Beyan

No Aplicabile

Teşekkür

I would like to thank Dr Bashar IBRAHIM for her support in the study.

Kaynakça

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