Parkinson Hastalığında SİBO (İnce Bağırsak Bakteri Aşırı Çoğalması): WOS örneği ile Bibliyometrik İnceleme

Öz

Amaç: Bu çalışmada Parkinson Hastalığında (PH) ince bağırsak bakteri aşırı çoğalması (SİBO) konusunda 2024 öncesi yayınlanan makalelerin niteliksel özelliklerinin araştırılması ve ileride yapılacak çalışmalar için araştırmacılara yol gösterilmesi amaçlanmıştır. Gereç ve Yöntemler: Web of Science veri tabanında arama kriterlerine “Parkinson Disease” ve “Small İntestinal Bacterial Overgrowth” anahtar kelimeleri girilerek tespit edilen 41 makale önceden belirlenmiş olan ölçütler etrafında değerlendirilmiştir. Bu çalışmada verilerin analizinde içerik analizi tekniğinden yararlanılarak bir durum çalışma örneği ortaya konmuştur. Yayınların yılları ve tipleri, yayın yapan ülkeler ve merkezler, yayınların yer aldığı dergiler, yayın yapan araştırmacılar, yayınların atıf alma sayıları ve en fazla atıf alan yayınların incelemeleri yapılmıştır. Bulgular: WOS veri tabanında ulaşılan 41 makaleden 26 tanesinin incelenmek istenen konuyla ilişkisi tespit edilmiştir. Bu konuda yapılan ilk yayın 2005 yılına aittir ve yayınların çoğunluğunu makaleler oluşturmaktadır. En çok yayın yapan bilim dalları klinik nöroloji ve gastroenteroloji olup en fazla yayının bulunduğu dergiler Parkinsonism and Related Disorders, Movevemet Disorders ve Gastroenterology’dir. Kanada, Çin ve USA en fazla yayının üretildiği ülkeler olup en fazla yayın yapan merkezler sırasıyla Universty Healthy Network Toronto ve Universty of Toronto’dur. En çok atıf alan yayın olan “Gastrointestinal dysfunction in Parkinson's disease” 2015 yılında Fasona ve arkadaşları tarafından yapılmış olup Lancet Neurology ‘de yayınlanmıştır. Sonuç: Parkinson hastalığı ve SİBO ilişkisini inceleyen çalışma sayısı az olmakla birlikte son yıllarda dünya literatüründe konuya olan ilginin arttığı tespit edilmiştir. Bu konuda ülkemizdeki merkezlere ait yayın bulunmamakla birlikte ülkemizde yayınlanan dergilerde de herhangi bir yayına rastlanmaması dikkat çekmektedir. Bu konudaki araştırmaların Parkinson Hastalığının etyopatogenezine ışık tutacak ve hastaların klinik bulgularında iyileşmeye katkıda bulunabilecek sonuçlar elde etme potansiyelinden dolayı özellikle genç araştırmacılar tarafından tercih edilebilecek için bir çalışma alanı olacağı düşüncesindeyiz.

Anahtar Kelimeler

• Parkinson Hastalığı
• ince bağırsak bakteri aşırı çoğalması
• SİBO
• bibliyometrik analiz

SIBO (Small Intestinal Bacterial Overgrowth) in Parkinson's Disease: Bibliometric Review with WOS Example

Öz

Aim: This study aims to investigate the qualitative characteristics of articles published before 2024 on small intestinal bacterial overgrowth (SIBO) in Parkinson's Disease (PD) and to guide researchers for future studies. Materials and Methods: The 41 articles identified by entering the keywords “Parkinson Disease” and “Small Intestinal Bacterial Overgrowth” into the search criteria in the Web of Science database were evaluated around the previously determined criteria. In this study, a case study example was presented by using the content analysis technique in the analysis of the data. The years and types of publications, the countries and centers that published, the journals in which the publications were published, the researchers who published, the number of citations of the publications and the most cited publications were examined. Results: When the 41 articles accessed in the WOS database were examined, it was determined that 26 of them were related to the subject to be examined. The first publication on this subject was from 2005 and the majority of the documents were articles. The most published branches are clinical neurology and gastroenterology, and the journals with the most publications are Parkinsonism and Related Disorders, Movevemet Disorders, and Gastroenterology. Canada, China, and the USA are the countries with the most publications, and the centers with the most publications are University Healthy Network Toronto and University of Toronto, respectively. The most cited publication, “Gastrointestinal dysfunction in Parkinson's disease”, was made by Fasona and colleagues in 2015 and published in Lancet Neurology. Conclusion: Although the number of studies examining the relationship between Parkinson's disease and SIBO is low, it has been determined that interest in the subject has increased in the world literature in recent years. While there are no publications from centers in our country on this subject, it is also noteworthy that no publications are found in journals published in our country. We believe that research on this subject will be a field of study that can be preferred especially by young researchers due to its potential to shed light on the etiopathogenesis of Parkinson's disease and to obtain results that can contribute to the improvement in the clinical findings of patients.

Anahtar Kelimeler

• Parkinson dieases
• SİBO
• intestinal bacterial overgrowth
• disbiosis
• bibliometric

Kaynakça

1. Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., Lehericy, S., Brooks, D. J., Rothwell, J. C., Hallett, M., DeLong, M. R., Marras, C., Tanner, C. M., Ross, G. W., Langston, J. W., Klein, C., … Stoessl, A. J. (2017). Past, present, and future of Parkinson’s disease: A special essay on the 200th Anniversary of the Shaking Palsy. Movement disorders : official journal of the Movement Disorder Society, 32(9), 1264–1310. https://doi.org/10.1002/mds.27115.
2. GBD 2016 Parkinson’s Disease Collaborators (2018). Global, regional, and national burden of Parkinson’s disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. Neurology, 17(11), 939–953. https://doi.org/10.1016/S1474-4422(18)30295-3.
3. Li, X., Feng, X., Jiang, Z., & Jiang, Z. (2021). Association of small intestinal bacterial overgrowth with Parkinson’s disease: a systematic review and meta-analysis. Gut pathogens, 13(1), 25. https://doi.org/10.1186/s13099-021-00420-w.
4. Gasbarrini, A., Lauritano, E. C., Gabrielli, M., Scarpellini, E., Lupascu, A., Ojetti, V., & Gasbarrini, G. (2007). Small intestinal bacterial overgrowth: diagnosis and treatment. Digestive diseases (Basel, Switzerland), 25(3), 237–240. https://doi.org/10.1159/000103892.
5. Rezaie, A., Pimentel, M., & Rao, S. S. (2016). How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach. Current gastroenterology reports, 18(2), 8. https://doi.org/10.1007/s11894-015-0482-9.
6. Efremova, I., Maslennikov, R., Poluektova, E., Vasilieva, E., Zharikov, Y., Suslov, A., Letyagina, Y., Kozlov, E., Levshina, A., & Ivashkin, V. (2023). Epidemiology of small intestinal bacterial overgrowth. World journal of gastroenterology, 29(22), 3400–3421. https://doi.org/10.3748/wjg.v29.i22.3400.
7. Wang, Q., Luo, Y., Ray Chaudhuri, K., Reynolds, R., Tan, E. K., & Pettersson, S. (2021). The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options. Brain: a journal of neurology, 144(9), 2571–2593. https://doi.org/10.1093/brain/awab156
8. Zhou, S., Li, B., Deng, Y., Yi, J., Mao, G., Wang, R., Zeng, W., Liu, B., Wu, D., & Liu, F. (2023). Meta-analysis of the relations between gut microbiota and pathogens and Parkinson’s disease. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 32(6), 613–621. https://doi.org/10.17219/acem/157193.

9. Safarpour, D., Brumbach, B. H., Arena, M., Quinn, J., Diamond, S., Nutt, J. G., & Pfeiffer, R. (2022). Gastrointestinal Motility and Response to Levodopa in Parkinson’s Disease: A Proof-of-Concept Study. Movement disorders: official journal of the Movement Disorder Society, 37(10), 2153–2158. https://doi.org/10.1002/mds.29176.
10. Zhou, Q., Yang, B., Zhu, Y., Wang, F., Tai, Y., Liu, Z., Chen, J., Liang, C., Yang, H., Pang, A., & Yang, X. (2024). Association of bacterial overgrowth in the small intestine with cortical thickness and functional connectivity in Parkinson’s disease involving mild cognitive impairment. Brain imaging and behavior, 10.1007/s11682-024-00948-w. Advance online publication. https://doi.org/10.1007/s11682-024-00948-w.
11. Dănău, A., Dumitrescu, L., Lefter, A., Tulbă, D., & Popescu, B. O. (2021). Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease. International journal of molecular sciences, 22(21), 11663. https://doi.org/10.3390/ijms222111663.
12. Justich, M. B., Rojas, O. L., & Fasano, A. (2023). The Role of Helicobacter pylori and Small Intestinal Bacterial Overgrowth in Parkinson’s Disease. Seminars in neurology, 43(4), 553–561. https://doi.org/10.1055/s-0043-1771468.
13. Beckers, M., Koehler, P. J., Wanten, G. J. A., & Bloem, B. R. (2023). Berlin Bowel Bothers: Might Adolf Hitler’s Gut Problems Have Been Parkinson-Related?. European neurology, 86(3), 222–227. https://doi.org/10.1159/000530166
14. van Kessel, S. P., Bullock, A., van Dijk, G., & El Aidy, S. (2022). Parkinson’s Disease Medication Alters Small Intestinal Motility and Microbiota Composition in Healthy Rats. mSystems, 7(1), e0119121. https://doi.org/10.1128/msystems.01191-21.
15. Dănău, A., Dumitrescu, L., Lefter, A., Tulbă, D., & Popescu, B. O. (2021). Small Intestinal Bacterial Overgrowth as Potential Therapeutic Target in Parkinson’s Disease. International journal of molecular sciences, 22(21), 11663. https://doi.org/10.3390/ijms222111663.
16. Fu, P., Gao, M., & Yung, K. K. L. (2020). Association of Intestinal Disorders with Parkinson’s Disease and Alzheimer’s Disease: A Systematic Review and Meta-Analysis. ACS chemical neuroscience, 11(3), 395–405. https://doi.org/10.1021/acschemneuro.9b00607.
17. Hasuike, Y., Endo, T., Koroyasu, M., Matsui, M., Mori, C., Yamadera, M., Fujimura, H., & Sakoda, S. (2020). Bile acid abnormality induced by intestinal dysbiosis might explain lipid metabolism in Parkinson’s disease. Medical hypotheses, 134, 109436. https://doi.org/10.1016/j.mehy.2019.109436.
18. Vizcarra, J. A., Wilson-Perez, H. E., Fasano, A., & Espay, A. J. (2018). Small intestinal bacterial overgrowth in Parkinson’s disease: Tribulations of a trial. Parkinsonism & related disorders, 54, 110–112. https://doi.org/10.1016/j.parkreldis.2018.04.003.
19. DiBaise, J. K., Crowell, M. D., Driver-Dunckley, E., Mehta, S. H., Hoffman-Snyder, C., Lin, T., & Adler, C. H. (2018). Weight Loss in Parkinson’s Disease: No Evidence for Role of Small Intestinal Bacterial Overgrowth. Journal of Parkinson’s disease, 8(4), 571–581. https://doi.org/10.3233/JPD-181386.
20. Holt P. R. (2007). Intestinal malabsorption in the elderly. Digestive diseases (Basel, Switzerland), 25(2), 144–150. https://doi.org/10.1159/000099479.
21. Niu, X. L., Liu, L., Song, Z. X., Li, Q., Wang, Z. H., Zhang, J. L., & Li, H. H. (2016). Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease. Journal of neural transmission (Vienna, Austria : 1996), 123(12), 1381–1386. https://doi.org/10.1007/s00702-016-1612-8.
22. Barboza, J. L., Okun, M. S., & Moshiree, B. (2015). The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease. Expert opinion on pharmacotherapy, 16(16), 2449–2464. https://doi.org/10.1517/14656566.2015.1086747.
23. Barboza, J. L., Okun, M. S., & Moshiree, B. (2015). The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease. Expert opinion on pharmacotherapy, 16(16), 2449–2464. https://doi.org/10.1517/14656566.2015.1086747.
24. Fasano, A., Bove, F., Gabrielli, M., Petracca, M., Zocco, M. A., Ragazzoni, E., Barbaro, F., Piano, C., Fortuna, S., Tortora, A., Di Giacopo, R., Campanale, M., Gigante, G., Lauritano, E. C., Navarra, P., Marconi, S., Gasbarrini, A., & Bentivoglio, A. R. (2013). The role of small intestinal bacterial overgrowth in Parkinson’s disease. Movement disorders : official journal of the Movement Disorder Society, 28(9), 1241–1249. https://doi.org/10.1002/mds.25522
25. Fasano, A., Visanji, N. P., Liu, L. W., Lang, A. E., & Pfeiffer, R. F. (2015). Gastrointestinal dysfunction in Parkinson’s disease. The Lancet. Neurology, 14(6), 625–639. https://doi.org/10.1016/S1474-4422(15)00007-1.
26. Tan, A. H., Mahadeva, S., Thalha, A. M., Gibson, P. R., Kiew, C. K., Yeat, C. M., Ng, S. W., Ang, S. P., Chow, S. K., Tan, C. T., Yong, H. S., Marras, C., Fox, S. H., & Lim, S. Y. (2014). Small intestinal bacterial overgrowth in Parkinson’s disease. Parkinsonism & related disorders, 20(5), 535–540. https://doi.org/10.1016/j.parkreldis.2014.02.019.
27. Dobbs, R. J., Charlett, A., Dobbs, S. M., Weller, C., A Ibrahim, M. A., Iguodala, O., Smee, C., Plant, J. M., Lawson, A. J., Taylor, D., & Bjarnason, I. (2012). Leukocyte-subset counts in idiopathic parkinsonism provide clues to a pathogenic pathway involving small intestinal bacterial overgrowth. A surveillance study. Gut pathogens, 4(1), 12. https://doi.org/10.1186/1757-4749-4-12.
28. Gabrielli, M., Bonazzi, P., Scarpellini, E., Bendia, E., Lauritano, E. C., Fasano, A., Ceravolo, M. G., Capecci, M., Rita Bentivoglio, A., Provinciali, L., Tonali, P. A., & Gasbarrini, A. (2011). Prevalence of small intestinal bacterial overgrowth in Parkinson’s disease. Movement disorders : official journal of the Movement Disorder Society, 26(5), 889–892. https://doi.org/10.1002/mds.23566.
29. Hasuike Y., Endo T., Koroyasu M., Matsui M., Mori C., Yamadera M., Fujimura H., Sakoda S. Clinical features of Parkinson’s disease patients with small intestinal bacterial overgrowth. Abstracts / Journal of the Neurological Sciences 381 (2017) 188–373.
30. Dumitrescu, L., Marta, D., Dănău, A., Lefter, A., Tulbă, D., Cozma, L., Manole, E., Gherghiceanu, M., Ceafalan, L. C., & Popescu, B. O. (2021). Serum and Fecal Markers of Intestinal Inflammation and Intestinal Barrier Permeability Are Elevated in Parkinson’s Disease. Frontiers in neuroscience, 15, 689723. https://doi.org/10.3389/fnins.2021.689723.
31. Ostojic S. M. (2018). Inadequate Production of H2 by Gut Microbiota and Parkinson Disease. Trends in endocrinology and metabolism: TEM, 29(5), 286–288. https://doi.org/10.1016/j.tem.2018.02.006.
32. Su, A., Gandhy, R., Barlow, C., & Triadafilopoulos, G. (2017). Utility of the wireless motility capsule and lactulose breath testing in the evaluation of patients with Parkinson’s disease who present with functional gastrointestinal symptoms. BMJ open gastroenterology, 4(1), e000132. https://doi.org/10.1136/bmjgast-2017-000132.