Çocuklarda Atopik Dermatit Gelişimini Önlemek İçin Kullanılan Lipozomal Kozmetik Formülasyonlar Üzerine In Silico, In Vitro Çalışmaları

Öz

Amaç: Atopik dermatit (AD), çocukluk döneminde yüksek prevalansa sahip kronik ve inflamatuvar bir deri hastalığıdır. Mevcut topikal tedavilerin dermal penetrasyonunun yetersiz kalması, daha etkili ve güvenli taşıyıcı sistemlere olan ihtiyacı artırmaktadır. Bu çalışmanın amacı, çocuklarda atopik dermatit tedavisinde kullanılmak üzere lipozomal formülasyonların in silico ve in vitro yöntemlerle geliştirilmesi ve değerlendirilmesidir.
 Gereç ve Yöntem: Formülasyon bileşenleri optimize edilerek farklı lipit oranları için in silico stabilite ve etkileşim analizleri gerçekleştirildi. Ardından seçilen formülasyonlar laboratuvarda hazırlanarak yoğunluk, pH, viskozite, yüzey gerilimi ve elektriksel iletkenlik ölçümleri yapıldı. Tüm ölçümler kalibre edilmiş cihazlarla üçer tekrar halinde gerçekleştirildi. Formülasyon, temiz içeriğe uygunluğu ve irritasyon riskinin azaltılması hedeflenerek tasarlandı. Bulgular:Geliştirilen lipozomal formülasyonların fiziksel parametrelerinin stabil aralıkta olduğu, yüksek viskozite uyumu ve optimum pH profili gösterdiği belirlendi. Lipozomal yapının, etkin maddelerin dermal penetrasyonunu artırmaya uygun olduğu, aynı zamanda irritasyonsuz kullanım potansiyeline sahip bulunduğu ortaya kondu. Teorik hesaplamalar ile deneysel veriler arasında uyum gözlendi. Sonuç: Bu çalışma, lipozomal formülasyonların atopik dermatit tedavisinde etkili ve güvenli bir alternatif oluşturabileceğini göstermektedir. Özellikle pediatrik hastalarda yan etki riskini azaltarak tedaviye uyumu artırma potansiyeli taşımaktadır. Çalışma ayrıca çevreci ve temiz içerik yaklaşımıyla hazırlanan lipozomal sistemlerin ileride geliştirilecek nanofarmasötik tedavilere temel oluşturabileceğini göstermektedir.

Anahtar Kelimeler

• Çocuklarda atopik dermatit
• Lipozomal taşıyıcı sistemler
• in silico
• in vitro
• Transdermal penetrasyon

In Silico, In Vitro Studies on Liposomal Cosmetic Formulations Used to Prevent the Development of Atopic Dermatitis in Children

Öz

Objective:
Atopic dermatitis (AD) is a chronic inflammatory skin disease with high prevalence in childhood. The limited dermal penetration of current topical therapies highlights the need for more efficient and safer delivery systems. This study aims to develop and evaluate liposomal formulations for pediatric AD treatment using in silico and in vitro methodologies. Material and Methods: :
Formulation components were optimized, and various lipid ratios were analyzed through in silico stability and interaction modeling. Selected formulations were then prepared in the laboratory and evaluated through measurements of density, pH, viscosity, surface tension, and electrical conductivity. All analyses were performed in triplicate using calibrated instruments. The formulation was designed to minimize irritation and comply with clean-label principles. Results:
The developed liposomal formulations demonstrated stable physical characteristics, acceptable viscosity properties, and an optimal pH profile. The liposomal structure exhibited strong potential for enhancing dermal penetration of active compounds while reducing irritation risk. A strong consistency was observed between theoretical predictions and experimental findings. Conclusions:
This study demonstrates that liposomal formulations present an effective and safe alternative for the management of atopic dermatitis, particularly in pediatric patients. Their ability to enhance dermal penetration and reduce adverse effects suggests promising applicability in future nanopharmaceutical strategies. The environmentally conscious and clean-content design further supports their potential in modern dermatological therapeutics.

Anahtar Kelimeler

• Atopic dermatitis in Children
• Liposomal delivery systems
• in silico
• in vitro
• Transdermal penetration

Kaynakça

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