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Sleep disorders in the elderly

Yıl 2025, Cilt: 10 Sayı: 4, 138 - 151, 31.12.2025
https://doi.org/10.58854/jicm.1842301

Öz

Physiological changes observed during sleep in the elderly predispose to sleep disorders. Common sleep disorders in the elderly include insomnia, obstructive sleep apnea syndrome, circadian rhythm sleep-wake disorders, REM sleep behavior disorder, restless legs syndrome, and hypersomnia. The first step in observing sleep disorders in the elderly is to educate the individual on sleep hygiene. Non-pharmacological treatment approaches should be prioritized. For pharmacological treatments, the general principles of small doses, slow increases, and short-term use are recommended for the elderly.

Kaynakça

  • Türkiye İstatistik Kurumu (TÜİK). Dünya Nüfus Günü, 2025 [İnternet]. 2025. Erişim adresi: https://data.tuik.gov.tr/Bulten/Index?p=Dunya-Nufus-Gunu-2025-54078
  • Wissler Gerdes EO, Zhu Y, Weigand BM, Tripathi U, Burns TC, Tchkonia T, Kirkland JL. Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases. Int Rev Neurobiol. 2020;155:203-34.
  • Weyand CM, Goronzy JJ. Aging of the Immune System. Mechanisms and Therapeutic Targets. Ann Am Thorac Soc. 2016;Suppl 5:422-8.
  • Hébert R. Functional decline in old age. CMAJ. 1997;157(8):1037-45.
  • Ramos AR, Wheaton AG, Johnson DA. Sleep Deprivation, Sleep Disorders, and Chronic Disease. Prev Chronic Dis. 2023;20:E77.
  • Klugherz LJ, Mansukhani MP, Kolla BP. Effects of Commonly Prescribed Medications on Sleep: A Review of the Literature. In Mayo Clinic Proceedings 2025;100(5):856-67.
  • Ezzie ME, Parsons JP, Mastronarde JG. Sleep and Obstructive Lung Diseases. Sleep Med Clin. 2008;3(4):505-15.
  • Ravichandran R, Gupta L, Singh M, Nag A, Thomas J, Panjiyar BK. The Interplay Between Sleep Disorders and Cardiovascular Diseases: A Systematic Review. Cureus. 2023;15(9):e45898.
  • Che T, Yan C, Tian D, Zhang X, Liu X, Wu Z. The association between sleep and metabolic syndrome: a systematic review and meta-analysis. Frontiers in Endocrinology 2021;12: 773646.
  • Seiger AN, Penzel T, Fietze I. Chronic pain management and sleep disorders. Cell Rep Med. 2024;5(10):101761.
  • Garcia AN, Salloum IM. Polysomnographic sleep disturbances in nicotine, caffeine, alcohol, cocaine, opioid, and cannabis use: a focused review. The American journal on addictions 2015; 24(7):590-8.
  • Suzuki K, Miyamoto M, Hirata K. Sleep disorders in the elderly: Diagnosis and management. J Gen Fam Med. 2017;18(2):61-71.
  • Lavoie CJ, Zeidler MR, Martin JL. Sleep and aging. Sleep Science Practice 2018;2(3).
  • Morin CM, Benca R. Chronic insomnia. Lancet 2012;379(9821):1129-41.
  • Patel D, Steinberg J, Patel P. Insomnia in the elderly: a review. Journal of Clinical Sleep Medicine 2018;14(6):1017-24.
  • Peng YT, Hsu YH, Chou MY, Chu CS, Su CS, Liang CK, Wang YC, Yang T, Chen LK, Lin YT. Factors associated with insomnia in older adult outpatients vary by gender: a cross-sectional study. BMC Geriatr. 2021;21(1):681.
  • Gooneratne NS, Vitiello MV. Sleep in older adults: normative changes, sleep disorders, and treatment options. Clin Geriatr Med. 2014;30(3):591-627.
  • Spielman AJ, Caruso LS, Glovinsky PB. A behavioral‐perspective on insomnia treatment. Psychiatr Clin North Am 1987;10:541‐53.
  • Amerikan Psikiyatri Birliği (2013). DSM-5 tanı ölçütleri başvuru el kitabı. E Köroğlu (Çev.). Ankara: Hekimler Yayın Birliği, 158.
  • Carvalho DZ, Kolla BP, McCarter SJ, St. Louis E K, Machulda MM, Przybelski SA et al. Associations of chronic insomnia, longitudinal cognitive outcomes, amyloid-PET, and white matter changes in cognitively normal older adults. Neurology 2025;105(7):e214155.
  • Diep NT, Tuan DA, Van Nguyen T, Anh HM, CuDH. Associations of sleep quality and fall risk among older adult outpatients at Thai Binh Medical University Hospital, Northern Vietnam. Frontiers in Sleep 2025;3:1486794.
  • Javaheri S, Redline S. Insomnia and Risk of Cardiovascular Disease. Chest. 2017;152(2):435-44.
  • Garbarino S, Lanteri P, Bragazzi NL, Magnavita N, Scoditti E. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol. 2021;4(1):1304.
  • Azizi-Zeinalhajlou A, Mirghafourvand M, Nadrian H, Samei Sis S, Matlabi H. The contribution of social isolation and loneliness to sleep disturbances among older adults: a systematic review. Sleep Biol Rhythms. 2022;20(2):153-63.
  • McCurry SM, Logsdon RG, Teri L, Vitiello MV. Evidence-based psychological treatments for insomnia in older adults. Psychol Aging. 2007;22(1):18–27.
  • Anderson KN. Insomnia and cognitive behavioural therapy—how to assess your patient and why it should be a standard part of care. Journal of thoracic disease 2018;10(1):S94.
  • Baillargeon L, Demers M, Ladouceur R. Stimulus-control: nonpharmacologic treatment for insomnia. Can Fam Physician. 1998;44:73-9.
  • Maurer LF, Schneider J, Miller CB, Espie CA, Kyle SD. The clinical effects of sleep restriction therapy for insomnia: A meta-analysis of randomised controlled trials. Sleep Med Rev. 2021;58:101493.
  • Zhao C, Li N, Miao W, He Y, Lin Y. A systematic review and meta-analysis on light therapy for sleep disorders in shift workers. Sci Rep. 2025;15(1):134.
  • Özdemir PG, Yılmaz E, Selvi Y, Boysan M. Psikiyatride Parlak Işık Tedavisi. Psikiyatride Güncel Yaklaşımlar 2017;9(2):177-88.
  • Korkutata A, Korkutata M, Lazarus M. The impact of exercise on sleep and sleep disorders. npj Biol Timing Sleep 2, 5 (2025). https://doi.org/10.1038/s44323-024-00018-w
  • Bjorvatn B, Waage S, Pallesen S. The association between insomnia and bedroom habits and bedroom characteristics: an exploratory cross-sectional study of a representative sample of adults. Sleep Health 2018;4(2):188-93.
  • Tanaka E, Yatsuya H, Uemura M, Murata C, Otsuka R, Toyoshima H et al. Associations of protein, fat, and carbohydrate intakes with insomnia symptoms among middle-aged Japanese workers. J Epidemiol. 2013;23(2):132-8.
  • Chaudhary NS, Grandner MA, Jackson NJ, Chakravorty S. Caffeine consumption, insomnia, and sleep duration: Results from a nationally representative sample. Nutrition. 2016;32(11-12):1193-9.
  • Britton A, Fat LN, Neligan A. The association between alcohol consumption and sleep disorders among older people in the general population. Sci Rep. 2020;10(1):5275.
  • Nuñez A, Rhee JU, Haynes P, Chakravorty S, Patterson F, Killgore WDS, Gallagher RA, Hale L, Branas C, Carrazco N, Alfonso-Miller P, Gehrels JA, Grandner MA. Smoke at night and sleep worse? The associations between cigarette smoking with insomnia severity and sleep duration. Sleep Health 2021;7(2):177-82.
  • Madari S, Golebiowski R, Mansukhani MP, Kolla BP. Pharmacological Management of Insomnia. Neurotherapeutics. 2021;18(1):44-52.
  • Monti JM, Monti D. Overview of currently available benzodiazepine and nonbenzodiazepine hypnotics In: Clinical pharmacology of sleep. Pandi‐Perumal SR, Monti JM, editors. Basel, Boston, Berlin: Birkhäuser Verlag, 2006;207–24.
  • Dixon CL, Harrison NL, Lynch JW, Keramidas A. Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity. Br J Pharmacol. 2015;172(14):3522-36.
  • Wu CC, Liao MH, Su CH, Poly TN, Lin MC. Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses. J Pers Med. 2023;13(10):1485.
  • Suzuki K, Miyamoto M, Miyamoto T, Sakuta H, Hirata K. The impact of sleep disturbances on neuroendocrine and autonomic functions. Nihon Rinsho 2012;70:1169–76
  • Neubauer DN. A review of ramelteon in the treatment of sleep disorders. Neuropsychiatr Dis Treat. 2008;4:69–79.
  • Rhyne DN, Anderson SL. Suvorexant in insomnia: efficacy, safety and place in therapy. Ther Adv Drug Saf. 2015;6:189–95.
  • Iannella G, Pace A, Bellizzi MG, Magliulo G, Greco A, De Virgilio A et al. The Global Burden of Obstructive Sleep Apnea. Diagnostics (Basel). 2025;15(9):1088.
  • Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K et al. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017;13(3):479-504.
  • Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA. 2004;291(16):2013-6.
  • Glasser M, Bailey N, McMillan A, Goff E, Morrell MJ. Sleep apnoea in older people. Breathe 2011;7(3):248-56.
  • Randerath W, de Lange J, Hedner J, Ho JPTF, Marklund M, Schiza S, Steier J, Verbraecken J. Current and novel treatment options for obstructive sleep apnoea. ERJ Open Res. 2022;8(2):00126-2022.
  • Johnson KG. APAP, BPAP, CPAP, and New Modes of Positive Airway Pressure Therapy. Adv Exp Med Biol. 2022;1384:297-330. doi: 10.1007/978-3-031-06413-5_18.
  • DiCaro MV, Lei K, Yee B, Tak T. The Effects of Obstructive Sleep Apnea on the Cardiovascular System: A Comprehensive Review. J Clin Med. 2024;13(11):3223.
  • Saad R, Black J, Bogan R, Jensen E, Lillaney P, Prince, P et al. Diagnosed Prevalence of Idiopathic Hypersomnia Among Adults in the United States. Sleep 2023;46(1):369-A369.
  • Bollu PC, Manjamalai S, Thakkar M, Sahota P. Hypersomnia. Mo Med. 2018;115(1):85-91.
  • Steele TA, St Louis EK, Videnovic A, Auger RR. Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Neurotherapeutics. 2021;18(1):53-74.
  • Wichniak A, Jankowski KS, Skalski M, Skwarło-Sońta K, Zawilska JB, Żarowski M, Poradowska E, Jernajczyk W. Treatment guidelines for Circadian Rhythm Sleep-Wake Disorders of the Polish Sleep Research Society and the Section of Biological Psychiatry of the Polish Psychiatric Association. Part I. Physiology, assessment and therapeutic methods. Psychiatr Pol. 2017;51(5):793-814.
  • Keijzer H, Smits MG, Duffy JF, Curfs LM. Why the dim light melatonin onset (dlmo) should be measured before treatment of patients with circadian rhythm sleep disorders. Sleep Med Rev 2014;18:333-9.
  • Hayakawa T, Uchiyama M, Kamei Y, Shibui K, Tagaya H, Asada T, Okawa M, Urata J, Takahashi K. Clinical analyses of sighted patients with non-24-hour sleep-wake syndrome: a study of 57 consecutively diagnosed cases. Sleep. 2005;28(8):945-52.
  • Trotti LM. REM sleep behaviour disorder in older individuals: epidemiology, pathophysiology and management. Drugs Aging. 2010;27(6):457-70.
  • Provini F, Vetrugno R, Meletti S, Plazzi G, Solieri L, Lugaresi E, Coccagna G, Montagna P. Motor pattern of periodic limb movements during sleep. Neurology. 2001;57(2):300-4.
  • Milligan SA, Chesson AL. Restless legs syndrome in the older adult: diagnosis and management. Drugs Aging. 2002;19(10):741-51
  • Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB; International Restless Legs Syndrome Study Group. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med. 2014;15(8):860-73.

Yaşlılarda Uyku Bozuklukları

Yıl 2025, Cilt: 10 Sayı: 4, 138 - 151, 31.12.2025
https://doi.org/10.58854/jicm.1842301

Öz

Yaşlılarda uyku sürecinde görülen fizyolojik değişiklikler uyku bozukluklarına zemin hazırlamaktadır. Yaşlılarda sık görülen uyku bozuklukları insomni, obstrüktif uyku apne sendromu, sirkadiyen ritm uyku-uyanıklık bozuklukları, REM uykusu davranış bozukluğu, huzursuz bacak sendromu ve hipersomnidir. Yaşlılarda uyku bozuklukları varlığında ilk yapılması gereken uyku hijyeni konusunda kişiye eğitim vermektir. Farmakolojik olmayan tedavi yaklaşımları öncelikli değerlendirilmelidir. Farmakolojik tedavilerde ise yaşlılardaki genel ilkeler olan küçük doz, yavaş artış ve kısa süreli kullanım önerilmektedir.

Etik Beyan

Yazı bir derleme yazısı olduğundan etik kurul onayı alınmamıştır

Destekleyen Kurum

yok

Kaynakça

  • Türkiye İstatistik Kurumu (TÜİK). Dünya Nüfus Günü, 2025 [İnternet]. 2025. Erişim adresi: https://data.tuik.gov.tr/Bulten/Index?p=Dunya-Nufus-Gunu-2025-54078
  • Wissler Gerdes EO, Zhu Y, Weigand BM, Tripathi U, Burns TC, Tchkonia T, Kirkland JL. Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases. Int Rev Neurobiol. 2020;155:203-34.
  • Weyand CM, Goronzy JJ. Aging of the Immune System. Mechanisms and Therapeutic Targets. Ann Am Thorac Soc. 2016;Suppl 5:422-8.
  • Hébert R. Functional decline in old age. CMAJ. 1997;157(8):1037-45.
  • Ramos AR, Wheaton AG, Johnson DA. Sleep Deprivation, Sleep Disorders, and Chronic Disease. Prev Chronic Dis. 2023;20:E77.
  • Klugherz LJ, Mansukhani MP, Kolla BP. Effects of Commonly Prescribed Medications on Sleep: A Review of the Literature. In Mayo Clinic Proceedings 2025;100(5):856-67.
  • Ezzie ME, Parsons JP, Mastronarde JG. Sleep and Obstructive Lung Diseases. Sleep Med Clin. 2008;3(4):505-15.
  • Ravichandran R, Gupta L, Singh M, Nag A, Thomas J, Panjiyar BK. The Interplay Between Sleep Disorders and Cardiovascular Diseases: A Systematic Review. Cureus. 2023;15(9):e45898.
  • Che T, Yan C, Tian D, Zhang X, Liu X, Wu Z. The association between sleep and metabolic syndrome: a systematic review and meta-analysis. Frontiers in Endocrinology 2021;12: 773646.
  • Seiger AN, Penzel T, Fietze I. Chronic pain management and sleep disorders. Cell Rep Med. 2024;5(10):101761.
  • Garcia AN, Salloum IM. Polysomnographic sleep disturbances in nicotine, caffeine, alcohol, cocaine, opioid, and cannabis use: a focused review. The American journal on addictions 2015; 24(7):590-8.
  • Suzuki K, Miyamoto M, Hirata K. Sleep disorders in the elderly: Diagnosis and management. J Gen Fam Med. 2017;18(2):61-71.
  • Lavoie CJ, Zeidler MR, Martin JL. Sleep and aging. Sleep Science Practice 2018;2(3).
  • Morin CM, Benca R. Chronic insomnia. Lancet 2012;379(9821):1129-41.
  • Patel D, Steinberg J, Patel P. Insomnia in the elderly: a review. Journal of Clinical Sleep Medicine 2018;14(6):1017-24.
  • Peng YT, Hsu YH, Chou MY, Chu CS, Su CS, Liang CK, Wang YC, Yang T, Chen LK, Lin YT. Factors associated with insomnia in older adult outpatients vary by gender: a cross-sectional study. BMC Geriatr. 2021;21(1):681.
  • Gooneratne NS, Vitiello MV. Sleep in older adults: normative changes, sleep disorders, and treatment options. Clin Geriatr Med. 2014;30(3):591-627.
  • Spielman AJ, Caruso LS, Glovinsky PB. A behavioral‐perspective on insomnia treatment. Psychiatr Clin North Am 1987;10:541‐53.
  • Amerikan Psikiyatri Birliği (2013). DSM-5 tanı ölçütleri başvuru el kitabı. E Köroğlu (Çev.). Ankara: Hekimler Yayın Birliği, 158.
  • Carvalho DZ, Kolla BP, McCarter SJ, St. Louis E K, Machulda MM, Przybelski SA et al. Associations of chronic insomnia, longitudinal cognitive outcomes, amyloid-PET, and white matter changes in cognitively normal older adults. Neurology 2025;105(7):e214155.
  • Diep NT, Tuan DA, Van Nguyen T, Anh HM, CuDH. Associations of sleep quality and fall risk among older adult outpatients at Thai Binh Medical University Hospital, Northern Vietnam. Frontiers in Sleep 2025;3:1486794.
  • Javaheri S, Redline S. Insomnia and Risk of Cardiovascular Disease. Chest. 2017;152(2):435-44.
  • Garbarino S, Lanteri P, Bragazzi NL, Magnavita N, Scoditti E. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol. 2021;4(1):1304.
  • Azizi-Zeinalhajlou A, Mirghafourvand M, Nadrian H, Samei Sis S, Matlabi H. The contribution of social isolation and loneliness to sleep disturbances among older adults: a systematic review. Sleep Biol Rhythms. 2022;20(2):153-63.
  • McCurry SM, Logsdon RG, Teri L, Vitiello MV. Evidence-based psychological treatments for insomnia in older adults. Psychol Aging. 2007;22(1):18–27.
  • Anderson KN. Insomnia and cognitive behavioural therapy—how to assess your patient and why it should be a standard part of care. Journal of thoracic disease 2018;10(1):S94.
  • Baillargeon L, Demers M, Ladouceur R. Stimulus-control: nonpharmacologic treatment for insomnia. Can Fam Physician. 1998;44:73-9.
  • Maurer LF, Schneider J, Miller CB, Espie CA, Kyle SD. The clinical effects of sleep restriction therapy for insomnia: A meta-analysis of randomised controlled trials. Sleep Med Rev. 2021;58:101493.
  • Zhao C, Li N, Miao W, He Y, Lin Y. A systematic review and meta-analysis on light therapy for sleep disorders in shift workers. Sci Rep. 2025;15(1):134.
  • Özdemir PG, Yılmaz E, Selvi Y, Boysan M. Psikiyatride Parlak Işık Tedavisi. Psikiyatride Güncel Yaklaşımlar 2017;9(2):177-88.
  • Korkutata A, Korkutata M, Lazarus M. The impact of exercise on sleep and sleep disorders. npj Biol Timing Sleep 2, 5 (2025). https://doi.org/10.1038/s44323-024-00018-w
  • Bjorvatn B, Waage S, Pallesen S. The association between insomnia and bedroom habits and bedroom characteristics: an exploratory cross-sectional study of a representative sample of adults. Sleep Health 2018;4(2):188-93.
  • Tanaka E, Yatsuya H, Uemura M, Murata C, Otsuka R, Toyoshima H et al. Associations of protein, fat, and carbohydrate intakes with insomnia symptoms among middle-aged Japanese workers. J Epidemiol. 2013;23(2):132-8.
  • Chaudhary NS, Grandner MA, Jackson NJ, Chakravorty S. Caffeine consumption, insomnia, and sleep duration: Results from a nationally representative sample. Nutrition. 2016;32(11-12):1193-9.
  • Britton A, Fat LN, Neligan A. The association between alcohol consumption and sleep disorders among older people in the general population. Sci Rep. 2020;10(1):5275.
  • Nuñez A, Rhee JU, Haynes P, Chakravorty S, Patterson F, Killgore WDS, Gallagher RA, Hale L, Branas C, Carrazco N, Alfonso-Miller P, Gehrels JA, Grandner MA. Smoke at night and sleep worse? The associations between cigarette smoking with insomnia severity and sleep duration. Sleep Health 2021;7(2):177-82.
  • Madari S, Golebiowski R, Mansukhani MP, Kolla BP. Pharmacological Management of Insomnia. Neurotherapeutics. 2021;18(1):44-52.
  • Monti JM, Monti D. Overview of currently available benzodiazepine and nonbenzodiazepine hypnotics In: Clinical pharmacology of sleep. Pandi‐Perumal SR, Monti JM, editors. Basel, Boston, Berlin: Birkhäuser Verlag, 2006;207–24.
  • Dixon CL, Harrison NL, Lynch JW, Keramidas A. Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity. Br J Pharmacol. 2015;172(14):3522-36.
  • Wu CC, Liao MH, Su CH, Poly TN, Lin MC. Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses. J Pers Med. 2023;13(10):1485.
  • Suzuki K, Miyamoto M, Miyamoto T, Sakuta H, Hirata K. The impact of sleep disturbances on neuroendocrine and autonomic functions. Nihon Rinsho 2012;70:1169–76
  • Neubauer DN. A review of ramelteon in the treatment of sleep disorders. Neuropsychiatr Dis Treat. 2008;4:69–79.
  • Rhyne DN, Anderson SL. Suvorexant in insomnia: efficacy, safety and place in therapy. Ther Adv Drug Saf. 2015;6:189–95.
  • Iannella G, Pace A, Bellizzi MG, Magliulo G, Greco A, De Virgilio A et al. The Global Burden of Obstructive Sleep Apnea. Diagnostics (Basel). 2025;15(9):1088.
  • Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K et al. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017;13(3):479-504.
  • Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA. 2004;291(16):2013-6.
  • Glasser M, Bailey N, McMillan A, Goff E, Morrell MJ. Sleep apnoea in older people. Breathe 2011;7(3):248-56.
  • Randerath W, de Lange J, Hedner J, Ho JPTF, Marklund M, Schiza S, Steier J, Verbraecken J. Current and novel treatment options for obstructive sleep apnoea. ERJ Open Res. 2022;8(2):00126-2022.
  • Johnson KG. APAP, BPAP, CPAP, and New Modes of Positive Airway Pressure Therapy. Adv Exp Med Biol. 2022;1384:297-330. doi: 10.1007/978-3-031-06413-5_18.
  • DiCaro MV, Lei K, Yee B, Tak T. The Effects of Obstructive Sleep Apnea on the Cardiovascular System: A Comprehensive Review. J Clin Med. 2024;13(11):3223.
  • Saad R, Black J, Bogan R, Jensen E, Lillaney P, Prince, P et al. Diagnosed Prevalence of Idiopathic Hypersomnia Among Adults in the United States. Sleep 2023;46(1):369-A369.
  • Bollu PC, Manjamalai S, Thakkar M, Sahota P. Hypersomnia. Mo Med. 2018;115(1):85-91.
  • Steele TA, St Louis EK, Videnovic A, Auger RR. Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. Neurotherapeutics. 2021;18(1):53-74.
  • Wichniak A, Jankowski KS, Skalski M, Skwarło-Sońta K, Zawilska JB, Żarowski M, Poradowska E, Jernajczyk W. Treatment guidelines for Circadian Rhythm Sleep-Wake Disorders of the Polish Sleep Research Society and the Section of Biological Psychiatry of the Polish Psychiatric Association. Part I. Physiology, assessment and therapeutic methods. Psychiatr Pol. 2017;51(5):793-814.
  • Keijzer H, Smits MG, Duffy JF, Curfs LM. Why the dim light melatonin onset (dlmo) should be measured before treatment of patients with circadian rhythm sleep disorders. Sleep Med Rev 2014;18:333-9.
  • Hayakawa T, Uchiyama M, Kamei Y, Shibui K, Tagaya H, Asada T, Okawa M, Urata J, Takahashi K. Clinical analyses of sighted patients with non-24-hour sleep-wake syndrome: a study of 57 consecutively diagnosed cases. Sleep. 2005;28(8):945-52.
  • Trotti LM. REM sleep behaviour disorder in older individuals: epidemiology, pathophysiology and management. Drugs Aging. 2010;27(6):457-70.
  • Provini F, Vetrugno R, Meletti S, Plazzi G, Solieri L, Lugaresi E, Coccagna G, Montagna P. Motor pattern of periodic limb movements during sleep. Neurology. 2001;57(2):300-4.
  • Milligan SA, Chesson AL. Restless legs syndrome in the older adult: diagnosis and management. Drugs Aging. 2002;19(10):741-51
  • Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB; International Restless Legs Syndrome Study Group. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med. 2014;15(8):860-73.
Toplam 60 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Derleme
Yazarlar

Leman İnanç

Hüseyin Can 0000-0002-4686-7879

Gönderilme Tarihi 15 Aralık 2025
Kabul Tarihi 26 Aralık 2025
Yayımlanma Tarihi 31 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 10 Sayı: 4

Kaynak Göster

APA İnanç, L., & Can, H. (2025). Yaşlılarda Uyku Bozuklukları. Journal of Immunology and Clinical Microbiology, 10(4), 138-151. https://doi.org/10.58854/jicm.1842301
AMA İnanç L, Can H. Yaşlılarda Uyku Bozuklukları. J Immunol Clin Microbiol. Aralık 2025;10(4):138-151. doi:10.58854/jicm.1842301
Chicago İnanç, Leman, ve Hüseyin Can. “Yaşlılarda Uyku Bozuklukları”. Journal of Immunology and Clinical Microbiology 10, sy. 4 (Aralık 2025): 138-51. https://doi.org/10.58854/jicm.1842301.
EndNote İnanç L, Can H (01 Aralık 2025) Yaşlılarda Uyku Bozuklukları. Journal of Immunology and Clinical Microbiology 10 4 138–151.
IEEE L. İnanç ve H. Can, “Yaşlılarda Uyku Bozuklukları”, J Immunol Clin Microbiol, c. 10, sy. 4, ss. 138–151, 2025, doi: 10.58854/jicm.1842301.
ISNAD İnanç, Leman - Can, Hüseyin. “Yaşlılarda Uyku Bozuklukları”. Journal of Immunology and Clinical Microbiology 10/4 (Aralık2025), 138-151. https://doi.org/10.58854/jicm.1842301.
JAMA İnanç L, Can H. Yaşlılarda Uyku Bozuklukları. J Immunol Clin Microbiol. 2025;10:138–151.
MLA İnanç, Leman ve Hüseyin Can. “Yaşlılarda Uyku Bozuklukları”. Journal of Immunology and Clinical Microbiology, c. 10, sy. 4, 2025, ss. 138-51, doi:10.58854/jicm.1842301.
Vancouver İnanç L, Can H. Yaşlılarda Uyku Bozuklukları. J Immunol Clin Microbiol. 2025;10(4):138-51.

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