Prevalence of cagA and babA2 positive Helicobacter pylori strains in dyspeptic patients in Iran

Yıl 2016, , 10 - 13, 21.05.2016

Mahsa Esmaeillu

https://doi.org/10.5455/jicm.5.20160514

Öz

Background: Helicobacter pylori genome encodes a
large number of virulence and adhesion factors that involved in bacterial
adhesion to host cells and exerts its virulence effect with CagA
secretion.  In this study, we aimed to
examine the relationships between babA2
and cagA genotype and presence of
gastric disorders in patients from Iran.

Material and Methods: The presence of H.
pylori and selected genes (cagA and
babA2) were detected by PCR method
from the genomic DNA of 105 patients who had been diagnosed with gastric
disorders like chronic gastritis by endoscopic and histopathologic routes.

Results:
Presence of H. pylori (glmM gene) was detected in 85 out of 105
(80.9%) patients. According to our results cagA
gene was found in 66 out of 85 (77.6%) patients and babA2 gene was found in 80 out of 85 (94.1%) patient.

Conclusion: In
conclusion, the cagA and babA2 genotypes might be considered as
useful biomarkers for non-ulcer disease (NUD) patients and gastric disorders in
the geographic region of Iran and the presence of H. pylori strains with double-positive status is high clinical
relevance to H. pylori-associated
diseases.

Anahtar Kelimeler

Helicobacter pylori, babA2, cagA, gastric disorders

Kaynakça

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