Characterization of lymphocyte infiltration in molar pregnancies

Yıl 2016, Cilt: 1 Sayı: 3, 68 - 72, 30.12.2016

Jabbar Salman Hassan

https://izlik.org/JA35FP33HR

Öz

Background: In
normal pregnancy around 30% of stromal cells in decidualised endometrium are
leucocytes, lymphocyte subtypes may play a role in the pathogenesis of molar
pregnancies.
The aim of the study is to
investigate the pattern of infiltrating lymphocytes in paraffin embedded tissue
sections obtained from molar pregnancies.

Material and Methods: This study included thirty-five archived paraffin-embedded
samples of molar pregnancies; divided into 16 incomplete and 19 complete
hydatid mole. Then dual immunofluorescence staining was used for phenotyping of
lymphocytic infiltrate (CD3- CD19) and (CD4-CD8). Independent sample t-test was
used to compare the mean cell counts between different study groups.

Results: There
is higher T cells (CD3) infiltrate in complete hydatid mole than normal
placental tissue (p=0.003) and not significant with incomplete hydatid mole
(p=0.089). Plasma cells (CD19) were higher in both complete hydatid mole CHM
(p=0.012) and incomplete hydatid mole  
iCHM (p=0.013). Cytotoxic cells (CD8) were none significant in all
groups while Helper cells (CD4) were significantly higher in CHM (p=0.017) and
iCHM (p=0.025).

Conclusion: The
higher tissue infiltration with plasma cells and helper cells in both CHM and
iCHM highlight the importance of these cells in molar pregnancy pathogenesis.

Anahtar Kelimeler

Hydatid mole , lymphocytes infiltration , Complete hydatid mole , incomplete hydatid mole

Kaynakça

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