Influence of Essential Oil on the Properties of UV-crosslinked Polyacrylamide/sodium caseinate (PAAM/SC) Hydrogels

Yıl 2025, Cilt: 5 Sayı: 1, 262 - 272

Ahmetcan Gün , Azra Albayrak , Fatma Nur Parın , Recep İlhan , Uğur Parın

Öz

Presently, numerous studies have shown that hydrogels can help with wound healing in a variety of approaches. Oil-loaded protein-based hydrogels were fast produced via free radical photopolymerization (UV crosslinking). The water phase consisted of sodium caseinate polymer and acrylamide monomer, whereas the oil phase included orange blossom essential oil (OBEO). The bio-based surfactant β-cyclodextrin (β-CD) stabilized oil loaded-hydrogels. β-CD/OBEO complexes in specific proportions (1:1, 1:2, and 1:4) was added to water phase. ATR-FT-IR confirms the functional groups in hydrogels. The hydrogels have a swelling ratio above 280 % for 24 hours. The maximum compression strength for hydrogels with (β-CD/OBEO, 1:2) is almost 1 MPa. All oil-loaded hydrogels showed antibacterial efficiency against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), with inhibition zones of 6-10 mm. According to the findings, the synthesized hydrogels can be used as wound dressings in wound healing applications.

Anahtar Kelimeler

Polyacrylamide/sodium caseinate hydrogels, β-CD, Orange blossom essential oil (OBEO), Compression test, Antibacterial efficiency

Etik Beyan

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Destekleyen Kurum

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Proje Numarası

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Teşekkür

Bu çalışma 14. ULPAS'ta en iyi 3. bildiri olarak ve aynı zamanda JIENS dergisinde özel sayıda basılmak üzere seçilmiştir.

Uçucu yağın UV Çapraz Bağlı Poliakrilamid/sodyum kazeinat (PAAM / SC) Hidrojellerinin Özellikleri Üzerindeki Etkisi

Öz

Halihazırda çok sayıda çalışma, hidrojellerin çeşitli yaklaşımlarla yara iyileşmesine yardımcı olabileceğini göstermiştir. Yağ yüklü protein bazlı hidrojeller, serbest radikal fotopolimerizasyon (UV çapraz bağlama) yoluyla hızlı bir şekilde üretilmiştir. Su fazı sodyum kazeinat polimeri ve akrilamid monomerinden oluşurken, yağ fazı portakal çiçeği esansiyel yağı (OBEO) içeriyordu. Biyo-bazlı yüzey aktif madde β-siklodekstrin (β-CD) yağ yüklü hidrojelleri stabilize etmiştir. β-CD/OBEO kompleksleri belirli oranlarda (1:1, 1:2 ve 1:4) su fazına eklenmiştir. ATR-FT-IR hidrojellerdeki fonksiyonel grupları doğrulamıştır. Hidrojeller 24 saat boyunca %280'in üzerinde bir şişme oranına sahiptir. (β-CD/OBEO, 1:2) içeren hidrojeller için maksimum sıkıştırma mukavemeti neredeyse 1 MPa'dır. Tüm yağ yüklü hidrojeller, Escherichia coli (E. coli) ve Staphylococcus aureus'a (S. aureus) karşı 6-10 mm'lik inhibisyon zonları ile antibakteriyel etkinlik göstermiştir. Elde edilen bulgulara göre, sentezlenen hidrojeller yara iyileştirme uygulamalarında yara örtüsü olarak kullanılabilir.

Anahtar Kelimeler

Poliakrilamid/sodyum kazeinat hidrojeller, β-CD, Portakal çiçeği esansiyel yağı (OBEO), Basma testi, Antibakteriyel etkinlik

Proje Numarası

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Kaynakça

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