Kalkon Türevlerinin Antikanser Mekanizmaları

Yıl 2023, , 1633 - 1646, 01.09.2023

Yaren Yıldız , Ferda Arı

https://doi.org/10.21597/jist.1259106

Öz

Kanser; hücrelerin kontrolsüz çoğalmalarına, immün sistemin gözetiminden kaçmalarına ve uzaktaki dokuları istila ederek yayılmalarına yol açan, metabolik değişiklikler geçirdikleri bir süreçtir. Hayatı boyunca her beş kişiden biri, yaşamının bir döneminde kansere yakalanmaktadır. Geliştirilmiş olan tüm tedavi yöntemlerine rağmen, hala kanserin neden olduğu ölümler gelişmiş toplumlarda ikinci sırada yer almaktadır. Kemoterapik tedavilerde kanser hücresinin farklı metabolik yolaklarına etki eden çok çeşitli ilaçlar kullanılmaktadır. Anti-neoplastik özelliği ile bilinen paklitaksel ve dosetaksel gibi birçok bitkisel kökenli anti-kanser ilaç klinikte kullanılmaktadır. Bitkisel kökenli kemoterapötik ajanların çeşitli kanser türlerine karşı tedavi olanakları araştırılmaya devam edilmektedir. Son dönemlerde yapılan çalışmalarda, kanser tedavisinde farklı moleküler yolakları hedefleyebilen flavonoid bazlı bileşikler sentezlenmiştir. Flavonoid ailesine ait olan kalkonlarında farklı biyolojik etkilerinin yanı sıra anti-kanser aktiviteye sahip oldukları belirlenmiştir. Kalkon bileşiklerinin etki mekanizmasını ortaya çıkarmak için bilimsel araştırmalar devam etmektedir. Bu derlemede, kalkon türevlerinin anti-proliferasyon, apoptoz indüksiyonu, mikrotübül polimerizasyonu, anti-anjiyogenezis ve hücre döngüsünün durdurulması gibi mekanizmalar yoluyla anti-kanser rollerinden bahsedilmektedir.

Anahtar Kelimeler

Flavanoid, Kalkonlar, Anti-Kanser, Sitotoksisite

Destekleyen Kurum

Bursa Uludağ Üniversitesi

Anticancer Mechanisms of Chalcone Derivatives

Öz

Cancer; It is a process in which cells undergo metabolic changes that cause them to proliferate uncontrollably, escape the surveillance of the immune system, and spread by invading distant tissues. One out of every five people will develop cancer at some point in their life. Despite all the treatment methods that have been developed, deaths caused by cancer still rank second in developed societies. A wide variety of drugs are used in chemotherapy treatments that affect different metabolic pathways of cancer cells. Many herbal anti-cancer drugs such as paclitaxel and docetaxel, which are known for their anti-neoplastic properties, are used in the clinic. Treatment possibilities of herbal chemotherapeutic agents against various types of cancer continue to be investigated. In recent studies, flavonoid-based compounds that can target different molecular pathways in cancer treatment have been synthesized. It has been determined that chalcones, which belong to the flavonoid family, have anti-cancer activity as well as different biological effects. Scientific research continues to reveal the mechanism of action of chalcone compounds. In this review, the anti-cancer roles of chalcone derivatives through mechanisms such as anti-proliferation, apoptosis induction, microtubule polymerization, anti-angiogenesis and cell cycle arrest are discussed.

Anahtar Kelimeler

Flavonoid, Chalcones, Anti-Cancer, Cytotoxicity

Kaynakça

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