Use of Vibration Spectroscopy in the Diagnosis of Gynaecological Tumours and Determination of Treatment Efficacy

Öz

The aim of this study was to investigate the efficacy of radiotherapy in patients with gynecologic diagnosis and radiotherapy indications using vibrational spectroscopy as an alternative method to standard methods. Vibration spectroscopy is a non-invasive and sensitive technique for the diagnosis of gynecologic tumors and determination of treatment efficacy. This method analyzes biochemical components by examining the characteristic vibrational frequencies of molecules and includes techniques such as Raman spectroscopy and infrared (IR) spectroscopy. Raman spectroscopy analyzes protein, lipid and nucleic acid contents, with the capacity to identify biomolecular changes in cancerous tissues, while FTIR spectroscopy detects changes at the cellular level. Raman spectroscopy clearly revealed biochemical differences between cancerous and normal tissues. Significant changes in protein and lipid content were observed in cancerous tissues. CA-125 and HE-4 biomarker levels showed significant differences between before and after treatment. There was a strong correlation between spectroscopic data and biomarker levels. FTIR spectra were effective in identifying changes at the cellular level. Changes were detected in the FTIR spectra of cancer cells, especially in phospholipid and nucleic acid content.In conclusion, vibrational spectroscopy plays an important role as an alternative method to standard methods in the diagnosis of gynecologic tumors and determination of treatment efficacy, and its widespread use in clinical practice contributes significantly to successful outcomes in the management of gynecologic cancers.

Anahtar Kelimeler

• Gynaecological tumours
• radiotherapy
• treatment efficacy
• vibration spectoscopy

Kaynakça

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