Bisfenol A’nın Sıçan İnce Bağırsak Dokusunda Oluşturduğu Histopatolojik Değişiklikler Üzerine Taurin ve Kurkumin’in Koruyucu Rolü

Öz

Bisfenol A (BPA) endokrin bozucu özelliğe sahip bir kimyasaldır. Bu çalışmanın amacı, BPA’nın sıçan

ince bağırsak dokusunda meydana getirdiği toksik etkiye karşı taurin ve kurkuminin olası koruyucu etkilerini incelemektir.

Bu amaçla, kırk iki erkek albino sıçan yedi eşit gruba ayrılmıştır bunlar: kontrol, yağ, taurin(100 mg

kg-1 vücut ağırlığı), kurkumin(100 mg kg-1 vücut ağırlığı), bisfenol A (130 mg kg-1 vücut ağırlığı), BPA+taurin ve

BPA+kurkumin. Uygulamadan dört hafta sonra ince bağırsak dokuları histopatolojik incelemeler için alınmıştır.

BPA ince bağırsak dokusunda önemli histopatolojik değişimlere sebep olmuştur, taurin ve kurkumin ise tamamen

koruyucu etki oluşturmamıştır.

Anahtar Kelimeler

• Bisfenol A,histopatoloji,ince bağırsak,kurkumin,taurin

Bisphenol A-Induced Histopathological Alterations on Small Intestine Tissues of Rats: The Protective Role of Taurine and Curcumin

Öz

Bisphenol A (BPA) has endocrine-disrupting properties. The present study aimed to examine the

possible protective roles of curcumin and taurine against BPA-induced small intestine toxicity in rats. For this

purpose, forty-two adult albino male rats were divided seven equal groups: control, olive oil, curcumin (100 mg

kg-1 daily), taurine (100 mg kg-1 daily), BPA (130 mg kg-1 daily), curcumin+BPA, taurine+BPA. After four weeks on

treatment small intestine tissues were examined for histopathological examinations. BPA caused seriously toxicity

on small intestine tissues, but curcumin and taurine did not have completely protective effects of this damage.

Anahtar Kelimeler

• Bisphenol A,curcumin,histopathology,small intestine,taurine

Kaynakça

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