Investigation of Drug Release from Chitosan Fibers by QCM

Yıl 2019, , 1004 - 1012, 01.06.2019

Neslihan Nohut Maşlakcı

https://doi.org/10.21597/jist.451680

Öz

In this study, the electrospun fibers of chitosan (Ch)/poly (methyl methacrylate) (PMMA) (K1), Ch/PMMA (K2) containing 0.3 wt.% ibuprofen (Ibu) and Ch/PMMA (K3) containing 0.6 wt.% Ibu were obtained for the first time by electrospinning technique. The controlled release of ibuprofen from the K2 and K3 fiber surfaces was investigated by quartz crystal microbalance (QCM) system. The results of QCM were compared with the results of ultraviolet-visible (UV-Vis) absorption spectroscopy. The morphological characteristics of the biocompatible fibers were characterized by scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS). It was observed that the best drug release mechanism from the drug release kinetics graphs was attributed to the K2 fiber structure obtained from the Ch/PMMA solution containing 0.3 wt.% Ibu and this was found to be the optimal drug concentration.

Anahtar Kelimeler

Electrospinning, chitosan, fiber, drug release

Kitosan Fiberlerinden İlaç Salımının QCM ile İncelenmesi

Öz

Bu çalışmada, kitosan (Ch)/poli(metil metakrilat) (PMMA) (K1), kütlece % 0.3 ibuprofen (Ibu) içeren Ch/PMMA (K2) ve kütlece % 0.6 Ibu içeren Ch/PMMA (K3) elektrospun fiberleri elektro-eğirme tekniği ile ilk kez elde edilmiştir. K2 ve K3 fiber yüzeylerinden ibuprofenin denetimli salımı kuvars kristal mikrobalans (QCM) sistemi ile incelenmiştir. QCM sonuçları, ultraviyole-görünür bölge (UV-Vis) absorpsiyon spektroskopisinin sonuçları ile karşılaştırılmıştır. Biyo-uyumlu fiberlerin morfolojik özellikleri taramalı elektron mikroskobu-enerji dağılım spektroskopisi (SEM-EDS) ile karakterize edilmiştir. İlaç salımına ait kinetik sonuçlardan en iyi ilaç salım mekanizmasının kütlece % 0.3 Ibu içeren Ch/PMMA çözeltisinden elde edilmiş olan K2 fiber yapısına ait olduğu ve bunun en ideal ilaç konsantrasyonu olduğu belirlenmiştir.

Anahtar Kelimeler

Elektro-eğirme, kitosan, fiber, ilaç salımı

Kaynakça

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