İnsanda Uzun Kodlanmayan RNA’ların Doku İfade Örüntüleri ve Varsayımsal İşlevlerinin Benzeşme Yayılması Algoritması ile İncelenmesi

Yıl 2017, Cilt: 7 Sayı: 2, 249 - 257, 30.06.2017

Gökhan Karakülah

Öz

Kümeleme yöntemleri, yüksek hacimli gen ifadesi örüntülerinden biyolojik olarak anlamlı bilginin elde
edilmesinde yaygın olarak kullanılmaktadır. Benzeşme yayılması algoritması, veri noktaları arasından örnekler
adı verilen küme merkezlerinin belirlendiği ve bunların etrafında kümelerin oluşturulduğu yeni bir yaklaşımdır.
Bu çalışmada, hastalık, gelişim ve farklılaşma gibi farklı hücresel olaylarda düzenleyici transkriptler olan uzun
kodlanmayan RNA’ların, benzeşme yayılması algoritması ile 16 farklı sağlıklı insan dokusundaki ifade örüntüleri
incelendi. Bununla beraber uzun kodlanmayan RNAların varsayımsal işlevleri, kümeleme yaklaşımı ile bilgisayar
tabanlı olarak tahminlendi ve kapsamlı bir ifade örüntüsü – işlev kataloğu hazırlandı

Anahtar Kelimeler

Benzeşme yayılması algoritması, biyoenformatik, kümeleme, uzun kodlanmayan RNA

Kaynakça

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