Antimicrobial Investigation and Synthesis of Novel 1H-Pyrazole-4- (5H)-yl Diazene Derivatives

Yıl 2018, Cilt: 8 Sayı: 2, 223 - 229, 30.06.2018

Havva Kurt Adnan Çetin , Sedat Bozarı

https://doi.org/10.21597/jist.428383

Cited By: 3

Öz

In this study, firstly, ethyl 1-(4-bromophenyl)-2-(1,3,5-triphenyl-1H-pyrazol-4-(5H)-ylidene)

hydrazine (1), which has starting material, was synthesized. A series of new 1H-pyrazol-4-yl diazene (2a-h)

derivatives were synthesized from reaction the obtained starting material and various hydrazines. The synthesized

compounds were confirmed by spectral methods such as elemental analysis, IR and NMR. Antibacterial activity of

the compounds were investigated by disc diffusion method against to Gram (+) and Gram (-) bacteria. Gentamicin

and Cefotaxime antibiotics were used as the control group. None of the doses showed any antibacterial activity

compared to the control.

Anahtar Kelimeler

Antimicrobial, control group, hydrazine, hydrazono, pyrazole

Yeni 1H-Pirazol-4-(5H)-il Diazen Türevlerinin Sentezi ve Antimikrobiyal Aktivitelerinin İncelenmesi

Öz

Bu çalışmada, ilk olarak başlangıç maddesi olan etil 1-(4-bromofenil)-2-(1,3,5-trifenil-1H-pirazol-4-(5H)-

ilden)hidrazinin (1) sentezi gerçekleştirildi. Elde edilen başlangıç maddesi çeşitli hidrazinlerle etkileştirilerek

bir seri yeni 1H-pirazol-4-il diazen (2a-h) türevleri sentezlendi. Sentezlenen bileşikler elementel analiz, IR ve

NMR gibi spektral yöntemlerle karakterize edildi. Sentezlenen bileşiklerin antibakteriyel aktiviteleri Gram (+)

ve Gram (-) bakteriler üzerinde disk difüzyon yöntemi kullanılarak araştırıldı. Kontrol grubu olarak Gentamisin,

Cefotaxime antibiyotikleri kullanılırken sentezlenen bileşiklerin kontrol grubu ile karşılaştırıldığında herhangi bir

dozun antibakteriyel aktivite göstermediği gözlendi.

Anahtar Kelimeler

Antimikrobiyal, hidrazin, hidrazon, kontrol grup, pirazol

Kaynakça

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