Yıl 2019, Cilt 9 , Sayı 3, Sayfalar 1503 - 1512 2019-09-01

Sıçan Eritrosit Glukoz 6-Fosfat Dehidrogenaz Enzim İnhibitörleri Olarak Tiyosemikarbazon Temelli Aza-Ylidlerin Sentezi
The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme

Yusuf TEMEL [1] , Sinan BAYINDIR [2]


Glukoz 6-fosfat dehidrogenaz (G6PD) enzimi NADPH, bazı amino asitler, sfingozin, steroid hormonları, kolesterol, yağ asitleri ve riboz 5-fosfat sentezi gibi pek çok biyokimyasal prosesin gerçekleşmesinde çok önemli bir role sahiptir. Bu çalışmada, tiyoasetazon, ambazon ve perklozon gibi birçok ilacın ana iskeletini oluşturan tiyosemikarbazon temelli aza-ylid (TSCAs) türevi 3a-3e moleküllerinin sentezi çevreci bir yaklaşımla gerçekleştirilerek, G6PD enzim aktivitesi üzerine in vitro şartlarda inhibisyon ve aktivasyon etkisi araştırılmıştır. Çalışmalar neticesinde, sentezlenen TSCAs türevleri 3a-3d moleküllerinin G6PD enzim aktivitesini 40.77 μM ile 58.0 μM aralığındaki IC50 değerlerinde inhibe ettiği belirlenmiştir.

Glucose 6-phosphate dehydrogenase (G6PD) enzyme plays an important role in various biochemical processes such as synthesis of cholesterol, fatty acids, sphingosine, steroid hormones, NADPH, some amino acids and ribose 5-phosphate. In this study, thiosemicarbazone-based aza-ylide (TSCAs) derivatives 3a-3e, which form the main framework of many drugs such as thioacetazone, ambazone, and perchlozone, were synthesized with a green approach and in vitro inhibitor or activator effects on G6PD enzyme activity was investigated. As a result of studies, TSCAs derivatives 3a-3d inhibited the G6PD enzyme activity with IC50 in the range of 40.77 μM to 58.0 μM for G6PD.

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Birincil Dil en
Konular Mühendislik, Kimya
Bölüm Kimya / Chemistry, Kimya Mühendisliği / Chemical Engineering
Yazarlar

Orcid: 0000-0001-8148-3718
Yazar: Yusuf TEMEL (Sorumlu Yazar)
Kurum: BİNGÖL ÜNİVERSİTESİ SOLHAN SAĞLIK HİZMETLERİ MESLEK YÜKSEK OKULU
Ülke: Turkey


Orcid: 0000-0002-7845-4497
Yazar: Sinan BAYINDIR
Kurum: BİNGÖL ÜNİVERSİTESİ FEN EDEBİYAT FAKÜLTESİ KİMYA BÖLÜMÜ
Ülke: Turkey


Tarihler

Başvuru Tarihi : 25 Ocak 2019
Kabul Tarihi : 22 Nisan 2019
Yayımlanma Tarihi : 1 Eylül 2019

Bibtex @araştırma makalesi { jist518012, journal = {Journal of the Institute of Science and Technology}, issn = {2146-0574}, eissn = {2536-4618}, address = {}, publisher = {Iğdır Üniversitesi}, year = {2019}, volume = {9}, pages = {1503 - 1512}, doi = {10.21597/jist.518012}, title = {The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme}, key = {cite}, author = {Temel, Yusuf and Bayındır, Sinan} }
APA Temel, Y , Bayındır, S . (2019). The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme. Journal of the Institute of Science and Technology , 9 (3) , 1503-1512 . DOI: 10.21597/jist.518012
MLA Temel, Y , Bayındır, S . "The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme". Journal of the Institute of Science and Technology 9 (2019 ): 1503-1512 <https://dergipark.org.tr/tr/pub/jist/issue/47916/518012>
Chicago Temel, Y , Bayındır, S . "The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme". Journal of the Institute of Science and Technology 9 (2019 ): 1503-1512
RIS TY - JOUR T1 - The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme AU - Yusuf Temel , Sinan Bayındır Y1 - 2019 PY - 2019 N1 - doi: 10.21597/jist.518012 DO - 10.21597/jist.518012 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 1503 EP - 1512 VL - 9 IS - 3 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.518012 UR - https://doi.org/10.21597/jist.518012 Y2 - 2019 ER -
EndNote %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme %A Yusuf Temel , Sinan Bayındır %T The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme %D 2019 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 9 %N 3 %R doi: 10.21597/jist.518012 %U 10.21597/jist.518012
ISNAD Temel, Yusuf , Bayındır, Sinan . "The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme". Journal of the Institute of Science and Technology 9 / 3 (Eylül 2019): 1503-1512 . https://doi.org/10.21597/jist.518012
AMA Temel Y , Bayındır S . The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme. Iğdır Üniv. Fen Bil Enst. Der.. 2019; 9(3): 1503-1512.
Vancouver Temel Y , Bayındır S . The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme. Journal of the Institute of Science and Technology. 2019; 9(3): 1512-1503.