Glukoz 6-fosfat dehidrogenaz (G6PD) enzimi NADPH, bazı amino asitler, sfingozin, steroid hormonları, kolesterol, yağ asitleri ve riboz 5-fosfat sentezi gibi pek çok biyokimyasal prosesin gerçekleşmesinde çok önemli bir role sahiptir. Bu çalışmada, tiyoasetazon, ambazon ve perklozon gibi birçok ilacın ana iskeletini oluşturan tiyosemikarbazon temelli aza-ylid (TSCAs) türevi 3a-3e moleküllerinin sentezi çevreci bir yaklaşımla gerçekleştirilerek, G6PD enzim aktivitesi üzerine in vitro şartlarda inhibisyon ve aktivasyon etkisi araştırılmıştır. Çalışmalar neticesinde, sentezlenen TSCAs türevleri 3a-3d moleküllerinin G6PD enzim aktivitesini 40.77 μM ile 58.0 μM aralığındaki IC50 değerlerinde inhibe ettiği belirlenmiştir.
Glucose 6-phosphate dehydrogenase (G6PD) enzyme plays an important role in various biochemical processes such as synthesis of cholesterol, fatty acids, sphingosine, steroid hormones, NADPH, some amino acids and ribose 5-phosphate. In this study, thiosemicarbazone-based aza-ylide (TSCAs) derivatives 3a-3e, which form the main framework of many drugs such as thioacetazone, ambazone, and perchlozone, were synthesized with a green approach and in vitro inhibitor or activator effects on G6PD enzyme activity was investigated. As a result of studies, TSCAs derivatives 3a-3d inhibited the G6PD enzyme activity with IC50 in the range of 40.77 μM to 58.0 μM for G6PD.
| Birincil Dil | en |
|---|---|
| Konular | Mühendislik, Kimya |
| Bölüm | Kimya / Chemistry, Kimya Mühendisliği / Chemical Engineering |
| Yazarlar |
|
| Tarihler |
Başvuru Tarihi
: 25 Ocak 2019
|
| Bibtex | @araştırma makalesi { jist518012,
journal = {Journal of the Institute of Science and Technology},
issn = {2146-0574},
eissn = {2536-4618},
address = {},
publisher = {Iğdır Üniversitesi},
year = {2019},
volume = {9},
pages = {1503 - 1512},
doi = {10.21597/jist.518012},
title = {The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme},
key = {cite},
author = {Temel, Yusuf and Bayındır, Sinan}
} |
| APA | Temel, Y , Bayındır, S . (2019). The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme. Journal of the Institute of Science and Technology , 9 (3) , 1503-1512 . DOI: 10.21597/jist.518012 |
| MLA | Temel, Y , Bayındır, S . "The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme". Journal of the Institute of Science and Technology 9 (2019 ): 1503-1512 <https://dergipark.org.tr/tr/pub/jist/issue/47916/518012> |
| Chicago | Temel, Y , Bayındır, S . "The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme". Journal of the Institute of Science and Technology 9 (2019 ): 1503-1512 |
| RIS | TY - JOUR T1 - The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme AU - Yusuf Temel , Sinan Bayındır Y1 - 2019 PY - 2019 N1 - doi: 10.21597/jist.518012 DO - 10.21597/jist.518012 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 1503 EP - 1512 VL - 9 IS - 3 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.518012 UR - https://doi.org/10.21597/jist.518012 Y2 - 2019 ER - |
| EndNote | %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme %A Yusuf Temel , Sinan Bayındır %T The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme %D 2019 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 9 %N 3 %R doi: 10.21597/jist.518012 %U 10.21597/jist.518012 |
| ISNAD | Temel, Yusuf , Bayındır, Sinan . "The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme". Journal of the Institute of Science and Technology 9 / 3 (Eylül 2019): 1503-1512 . https://doi.org/10.21597/jist.518012 |
| AMA | Temel Y , Bayındır S . The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme. Iğdır Üniv. Fen Bil Enst. Der.. 2019; 9(3): 1503-1512. |
| Vancouver | Temel Y , Bayındır S . The Synthesis of Thiosemicarbazone-Based Aza-Ylides as Inhibitors of Rat Erythrocyte Glucose 6-Phosphate Dehydrogenase Enzyme. Journal of the Institute of Science and Technology. 2019; 9(3): 1512-1503. |
