4-Amino-Tetrahidrokinolin Türevlerinin Organokatalizör Varlığında Sentezi ve Karakterizasyonu

Yıl 2020, Cilt: 10 Sayı: 1, 368 - 377, 01.03.2020

Mustafa Zahrettin Kazancıoğlu

https://doi.org/10.21597/jist.572079

Öz

4-Aminotetrahidrokinolin türevleri; organo Brønsted asit katalizörü eşliğinde anilin, N-vinilkarbamat ve substitüe halojen içeren aldehitin bir balona konulmasıyla tek kademede sentezlendi. 3 bileşenli Povarov reaksiyonu yöntemi kullanıldı. 4 farklı 4-Aminotetrahidrokinolin türevi sentezlendi ve 1H, 13C, Infrared Spektroskopisi (IR), Erime noktası (EN) ve Yüksek Çözünürlüklü Kütle Spektroskopisi (HRMS) gibi çeşitli metotlar kullanılarak yapı karakterizasyonları yapıldı.

Anahtar Kelimeler

Povarov reksiyonu, Tetrahidrokinolin, organokatalizör

Destekleyen Kurum

Kilis 7 Aralık Üniversitesi Yusuf Şerefoğlu Sağlık Bilimleri Fakültesi, 79000, Kilis

Teşekkür

Kilis 7 Aralık Üniversitesi İleri Teknoloji Uygulama ve Araştırma Merkezi

Synthesis and Characterization of 4-Amino-Tetrahydroquinoline Derivatives via Organocatalyst

Öz

4-Aminotetrahydroquinoline derivatives were synthesized as a single step by placing the aniline, N-vinylcarbamate and substituted halogen containing aldehyde in the presence of organo Brønsted acid catalyst. Three-component Povarov reaction method was used. Four different 4-aminotetrahydroquinoline derivatives were synthesized and Structural characterization was performed using various methods such as 1H, 13C, Infrared Spectroscopy (IR), melting point (MP) and High Resolution Mass Spectroscopy (HRMS).

Anahtar Kelimeler

Povarov reaction, Tetrahydroquinoline, Organocatalyst

Kaynakça

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