Yıl 2020, Cilt 10 , Sayı 2, Sayfalar 778 - 787 2020-06-01

Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats
Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats

Abdulahad DOĞAN [1] , Fatih DONMEZ [2] , Abdulhamit BATTAL [3] , Ali ASLAN [4] , Ozgur Ozan ANUK [5]


In this study, immunotoxic and neurotoxic effects of leaf infusion of Platanus orientalis L. (PO) were investigated in rats ethanol-induced toxicity. Neurotoxic effects of ethanol were evaluated by measuring acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in rat brain tissue. Immunotoxic effects were evaluated by adenosine deaminase (ADA) and myeloperoxidase (MPO) biomarkers in rat liver, lung, erythrocyte and spleen tissues. Thirty male Wistar rats were divided into five groups after toxicity study. The groups are explained as follow: Control, Ethanol 20 %, Ethanol 20 % + Silymarin (10 mg kg-1), Ethanol 20 % + PO-20 mg mL-1 infusion and Ethanol 20 % + PO-60 mg mL-1 infusion. The results showed that AChE and BChE activities statistically decreased in the groups treated with PO leaf infusion. While there was a statistically significant decrease in ADA and MPO activities in liver tissue of groups treated with PO leaf infusion. Also, MPO activity of erythrocyte in ethanol group was significantlly increased according to silymarin and PO-60 groups. On the other hand, there was no statistically significant finding was found in lung and spleen tissues. It was concluded that the infusion prepared from P. orientalis leaves suppressed to ethanol-induced neurotoxicity and immunotoxicity.

In this study, immunotoxic and neurotoxic effects of leaf infusion of Platanus orientalis L. (PO) were investigated in rats ethanol-induced toxicity. Neurotoxic effects of ethanol were evaluated by measuring acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in rat brain tissue. Immunotoxic effects were evaluated by adenosine deaminase (ADA) and myeloperoxidase (MPO) biomarkers in rat liver, lung, erythrocyte and spleen tissues. Thirty male Wistar rats were divided into five groups after toxicity study. The groups are explained as follow: Control, Ethanol 20 %, Ethanol 20 % + Silymarin (10 mg kg-1), Ethanol 20 % + PO-20 mg mL-1 infusion and Ethanol 20 % + PO-60 mg mL-1 infusion. The results showed that AChE and BChE activities statistically decreased in the groups treated with PO leaf infusion. While there was a statistically significant decrease in ADA and MPO activities in liver tissue of groups treated with PO leaf infusion. Also, MPO activity of erythrocyte in ethanol group was significantlly increased according to silymarin and PO-60 groups. On the other hand, there was no statistically significant finding was found in lung and spleen tissues. It was concluded that the infusion prepared from P. orientalis leaves suppressed to ethanol-induced neurotoxicity and immunotoxicity.

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Birincil Dil en
Konular Biyoloji
Yayınlanma Tarihi Haziran-2020
Bölüm Biyoloji / Biology
Yazarlar

Orcid: 0000-0002-5438-8560
Yazar: Abdulahad DOĞAN (Sorumlu Yazar)
Kurum: Van Yuzuncu Yil University
Ülke: Turkey


Orcid: 0000-0003-3958-1028
Yazar: Fatih DONMEZ
Kurum: Van Yuzuncu Yil University
Ülke: Turkey


Orcid: 0000-0001-6098-3908
Yazar: Abdulhamit BATTAL
Kurum: Van Yuzuncu Yil University
Ülke: Turkey


Orcid: 0000-0002-2637-4786
Yazar: Ali ASLAN
Kurum: Van Yuzuncu Yil University
Ülke: Turkey


Orcid: 0000-0002-9028-7118
Yazar: Ozgur Ozan ANUK
Kurum: Van Yuzuncu Yil University
Ülke: Turkey


Destekleyen Kurum Van Yuzuncu Yil University
Proje Numarası TAP-2019-8183
Teşekkür This study was financially supported by Van Yuzuncu Yil University Scientific Research Projects Department.
Tarihler

Başvuru Tarihi : 7 Kasım 2019
Kabul Tarihi : 20 Aralık 2019
Yayımlanma Tarihi : 1 Haziran 2020

Bibtex @araştırma makalesi { jist643987, journal = {Journal of the Institute of Science and Technology}, issn = {2146-0574}, eissn = {2536-4618}, address = {}, publisher = {Iğdır Üniversitesi}, year = {2020}, volume = {10}, pages = {778 - 787}, doi = {10.21597/jist.643987}, title = {Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats}, key = {cite}, author = {Doğan, Abdulahad and Donmez, Fatih and Battal, Abdulhamit and Aslan, Ali and Anuk, Ozgur Ozan} }
APA Doğan, A , Donmez, F , Battal, A , Aslan, A , Anuk, O . (2020). Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats . Journal of the Institute of Science and Technology , 10 (2) , 778-787 . DOI: 10.21597/jist.643987
MLA Doğan, A , Donmez, F , Battal, A , Aslan, A , Anuk, O . "Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats" . Journal of the Institute of Science and Technology 10 (2020 ): 778-787 <https://dergipark.org.tr/tr/pub/jist/issue/54316/643987>
Chicago Doğan, A , Donmez, F , Battal, A , Aslan, A , Anuk, O . "Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats". Journal of the Institute of Science and Technology 10 (2020 ): 778-787
RIS TY - JOUR T1 - Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats AU - Abdulahad Doğan , Fatih Donmez , Abdulhamit Battal , Ali Aslan , Ozgur Ozan Anuk Y1 - 2020 PY - 2020 N1 - doi: 10.21597/jist.643987 DO - 10.21597/jist.643987 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 778 EP - 787 VL - 10 IS - 2 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.643987 UR - https://doi.org/10.21597/jist.643987 Y2 - 2019 ER -
EndNote %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats %A Abdulahad Doğan , Fatih Donmez , Abdulhamit Battal , Ali Aslan , Ozgur Ozan Anuk %T Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats %D 2020 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 10 %N 2 %R doi: 10.21597/jist.643987 %U 10.21597/jist.643987
ISNAD Doğan, Abdulahad , Donmez, Fatih , Battal, Abdulhamit , Aslan, Ali , Anuk, Ozgur Ozan . "Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats". Journal of the Institute of Science and Technology 10 / 2 (Haziran 2020): 778-787 . https://doi.org/10.21597/jist.643987
AMA Doğan A , Donmez F , Battal A , Aslan A , Anuk O . Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats. Iğdır Üniv. Fen Bil Enst. Der.. 2020; 10(2): 778-787.
Vancouver Doğan A , Donmez F , Battal A , Aslan A , Anuk O . Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats. Journal of the Institute of Science and Technology. 2020; 10(2): 778-787.
IEEE A. Doğan , F. Donmez , A. Battal , A. Aslan ve O. Anuk , "Investigation of Neurotoxic and Immunotoxic Effects of the Chinar (Platanus orientalis L.) Tree Leaf Infusion Against Ethanol Toxicity in Rats", Journal of the Institute of Science and Technology, c. 10, sayı. 2, ss. 778-787, Haz. 2020, doi:10.21597/jist.643987