Araştırma Makalesi
PDF Zotero Mendeley EndNote BibTex Kaynak Göster

Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi

Yıl 2020, Cilt 10, Sayı 3, 1566 - 1575, 01.09.2020
https://doi.org/10.21597/jist.707835

Öz

Ekzojen gonadotropinler vasıtasıyla ovaryum stimülasyonu (OS) hem üreme biyolojisi ile ilgili deneysel çalışmalarda hem de in vitro fertilizasyon (IVF) ’da yaygın olarak kullanılan bir uygulamadır. Fakat yapılan bazı çalışmalardan elde edilen veriler OS’nin oosit, embriyo niteliği ve embriyogenez süreçlerine çeşitli olumsuz etkilerinin olabileceğine işaret etmektedir. Dolayısıyla, OS prosedürlerinin üreme ve diğer biyolojik süreçlerle olan olası etkilerini inceleyecek kapsamlı çalışmalara ihtiyaç duyulduğu düşünülmektedir. Serotonin ve melatoninin de oosit ve embriyo niteliğinde etkileri olan önemli hormonlar olduğu belirtilmektedir. Bununla birlikte farklı dozlarda uygulanan ekzojen gonadotropin uygulamalarının bu hormonlar üzerine etkisini inceleyen herhangi bir araştırma olmadığı anlaşılmaktadır. Bu nedenle bu araştırmada farklı dozlarda ekzojen gonadotropin uygulamasının serotonin ve melatonin düzeylerine etkisini fare modelinde incelemeyi amaçladık. Çalışmamızda fareler 5, 7.5, 10 ve 12.5 I.U. Gebe Kısrak Serum Gonadotropin/ İnsan Koriyonik Gonadotropin (PMSG/hCG) uygulamak üzere 4 farklı gruba (n=6) ayrıldı. Ekzojen gonadotropinlerle muamele sonrasında melatonin ve serotoninin düzeyleri çalışma gruplarına ait plazma örneklerinde ELISA yöntemi ile tespit edildi. Melatonin düzeyleri yönünden gruplar arasında anlamlı bir fark belirlenmezken, serotonin düzeyleri yönünden gruplar arasında anlamlı bir farkın olduğu gözlenmiştir. Yapılan grup içi karşılaştırmalarda 7.5 I.U. PMSG/hCG uygulanan grupta diğer gruplara nazaran serotonin düzeyleri yönünden anlamlı bir artışın olduğu saptandı. Sonuç olarak uyguladığımız ekzojen gonadotropin dozlarının melatonin düzeylerini etkilemediği ancak serotonin seviyelerini 7.5 I.U. PMSG/hCG uygulaması sonrasında diğer dozlara göre anlamlı olarak artırdığı anlaşılmaktadır. Daha yüksek ekzojen gonadotropin dozlarının bu hormonlara etkisini hayvanlarda ve insanlarda da inceleyecek ilave çalışmaların üreme biyolojisine katkı sunacağı düşünülmektedir.

Kaynakça

  • Agarwal A, Gupta S, Sikka S, 2006. The Role of Free Radicals and Antioxidants in Reproduction. Current Opinion in Obstetrics and Gynecology, 18(3):325-332.
  • Amireault P, Dubé F, 2005. Serotonin and Its Antidepressant-Sensitive Transport in Mouse Cumulus-Oocyte Complexes and Early Embryos. Biology of reproduction, 73(2):358-365.
  • Baart EB, Martini E, van den Berg I, Macklon N, Galjaard RH, Fauser B et al., 2006. Preimplantation Genetic Screening Reveals a High Incidence of Aneuploidy and Mosaicism in Embryos from Young Women Undergoing Ivf. Human Reproduction, 21(1):223-233.
  • Battista P, Condon W, 1986. Serotonin-Induced Stimulation of Progesterone Production by Cow Luteal Cells in Vitro. Reproduction, 76(1):231-238.
  • Battista P, Rexroad Jr C, Condon W, 1987. Mechanisms Inveolved in the Action of Serotonin-Induced Stimulation of Progesterone Production by Bovine Luteal Cells in Viitro. Molecular and cellular endocrinology, 51(1-2):145-151.
  • Boden MJ, Varcoe TJ, Kennaway DJ, 2013. Circadian Regulation of Reproduction: From Gamete to Offspring. Progress in biophysics and molecular biology, 113(3):387-397.
  • Bodis J, Bognàr B, Hartmann G, Török A, Csaba I, 1992. Measurement of Noradrenaline, Dopamine and Serotonin Contents in Follicular Fluid of Human Graafian Follicles after Superovulation Treatment. Gynecologic and obstetric investigation, 33(3):165-167.
  • Bodis J, Hartmann G, Tinneberg H-R, Török A, Hanf V, Papenfuss F et al., 1993. Relationship between the Monoamine, Progesterone and Estradiol Content in Follicular Fluid of Preovulatory Graafian Follicles after Superovulation Treatment. Gynecologic and obstetric investigation, 35(4):232-235.
  • Bódis J, Török A, Tinneberg H-R, Hanf V, Hamori M, Cledon P, 1992. Influence of Serotonin on Progesterone and Estradiol Secretion of Cultured Human Granulosa Cells. Fertility and sterility, 57(5):1008-1011.
  • Bódis J, Sulyok E, Kőszegi T, Prémusz V, Várnagy Á, Koppán M, 2019. Serum and Follicular Fluid Levels of Serotonin, Kisspeptin, and Brain-Derived Neurotrophic Factor in Patients Undergoing in Vitro Fertilization: An Observational Study: Neurohormones in Patients Receiving Ivf. Journal of International Medical Research:0300060519879330.
  • Ceinos R, Chansard M, Revel F, Calgari C, Miguez J, Simonneaux V, 2004. Analysis of Adrenergic Regulation of Melatonin Synthesis in Siberian Hamster Pineal Emphasizes the Role of Hiomt. NeuROTignals, 13(6):308-317.
  • Chenette PE, Sauer MV, Paulson RJ, 1990. Very high serum estradiol levels are not detrimental to clinical outcome of in vitro fertilization. Fertil Steril, 54(5):858–863.
  • Clausell D, Soliman K, 1978. Ovarian Serotonin Content in Relation to Ovulation. Experientia, 34(3):410-411.
  • Combelles Catherine MH, ve Albertini DF, 2003. Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse." Biology of Reproduction, 68(3):812-21.
  • Cooke MS, Evans MD, Dizdaroglu M, Lunec J, 2003. Oxidative DNA Damage: Mechanisms, Mutation, and Disease. The FASEB Journal, 17(10):1195-1214.
  • Ertzeid G, Storeng R, 2001. The Impact of Ovarian Stimulation on Implantation and Fetal Development in Mice. Human Reproduction, 16(2):221-225.
  • Espino J, Macedo M, Lozano G, Ortiz Á, Rodríguez C, Rodríguez AB et al., 2019. Impact of Melatonin Supplementation in Women with Unexplained Infertility Undergoing Fertility Treatment. Antioxidants, 8(9):338.
  • Forman R, Belaisch-Allart J, Fries N, Hazout A, Testart J, Frydman R, 1988. Evidence for an Adverse Effect of Elevated Serum Estradiol Concentrations on Embryo Implantation. Fertility and sterility, 49(1):118-122.
  • Ganguly S, Coon SL, Klein DC, 2002. Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell and tissue research, 309(1):127-137.
  • Gelety TJ, Buyalos RP, 1995. The influence of supraphysiologic estradiol levels on human nidation. J Assist Reprod Genet. 12(7):406–412.
  • Goldman B 2007. Reproductive Medicine: The First Cut: Nature Publishing Group.
  • Graveleau C, Paust H-J, Schmidt-Grimminger D, Mukhopadhyay AK, 2000. Presence of a 5-Ht7 Receptor Positively Coupled to Adenylate Cyclase Activation in Human Granulosa-Lutein Cells. The Journal of Clinical Endocrinology & Metabolism, 85(3):1277-1286.
  • Group IW 1998. Art into Science: Regulation of Fertility Techniques: Islat Working Group: American Association for the Advancement of Science.
  • Iwamatsu T, Toya Y, Sakai N, Terada Y, Nagata R, Nagahama Y, 1993. Effect of 5‐Hydroxytryptamine on Steroidogenesis and Oocyte Maturation in Pre‐Ovulatory Follicles of the Medaka Oryzias Latipes: (Medaka/Steroidogenesis/5‐Hydroxytryptamine/Foillicle/Oocyte Maturation). Development, growth & differentiation, 35(6):625-630.
  • Kandemir YB, Aydin C, Gorgisen G, 2017. The Effects of Melatonin on Oxidative Stress and Prevention of Primordial Follicle Loss Via Activation of Mtor Pathway in the Rat Ovary. Cell Mol Biol(Noisy le Grand), 63(100-106.
  • Kara M, Kutlu T, Soguoglu K, Devranoglu B, Cetinkaya T. 2012. Association between serum estradiol level on the hCG administration day and IVF-ICSI outcome. Iran J Reprod Med, 10(1):53–58.
  • Kierszenbaum AL, 2006. Histoloji Ve Hücre Biyolojisi. Ankara, Palme Yayıncılık.
  • Koçak A, Çolak A, 1996. Melatonin Ve Santral Sinir Sistemi. J Turgut Özal Medical Center, 3(237-244.
  • Kondapalli LA, Molinaro TA, Sammel DA, 2012. A decrease in serum estradiol levels after human chorionic gonadotrophin administration predicts significantly lower clinical pregnancy and live birth rates in vitro fertilization cycles. Hum Reprod, 27(9):2690–2697.
  • Koppan M, Bodis J, Verzar Z, Tinneberg H-R, Torok A, 2004. Serotonin May Alter the Pattern of Gonadotropin-Induced Progesterone Release of Human Granulosa Cells in Superfusion System. Endocrine, 24(2):155-159.
  • Lewiński A, Szymczykiewicz P, Sewerynek E, Wajs E, 1993. Effects of Pinealectomy and Melatonin Administration on Certain Indices of Ovarian Hyperplasia and/or Hypertrophy in Rats with Both Ovaries Intact or after Unilateral Ovariectomy. Joal of pineal research, 14(3):117-127.
  • Li S, Pelletier G, 1995. Involvement of Serotonin in the Regulation of Gnrh Gene Expression in the Male Rat Brain. Neuropeptides, 29(1):21-25.
  • Lv Y, Li Y, Li J, Bian C, Qin C, Shi Q, 2020. A comparative genomics study on the molecular evolution of serotonin/melatonin biosynthesizing enzymes in vertebrates. Frontiers in Molecular Biosciences, 7.
  • Nikitina L, Buznikov G, Galanov AY, Malchenko LA, Trubnikova OB, 2002. The Control of Oocyte Maturation in the Starfish and Amphibians by Serotonin and Its Antagonists. International Journal of Developmental Biology, 37(2):363-364.
  • Ozturk S, Yaba-Ucar A, Sozen B, Mutlu D, Demir N, 2016. Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos. ReprodFertil Dev, 28(3):375–383.
  • Prasad P, Ogawa S, Parhar I (2015). Role of Serotonin in Fish Reproduction. Front. NeuROTci. 9, 1e9.
  • Rehman R, Hussain Z, Faraz N, 2012. Effect of estradiol levels on pregnancy outcome in obese females. J Ayub Med Coll Abbottabad, 24(3):3–5.
  • Reiter RJ, 1993. The Melatonin Rhythm: Both a Clock and a Calendar. Experientia, 49(8):654-664.
  • Reiter RJ, Tan DX, Maldonado MD, 2005. Melatonin as an Antioxidant: Physiology Versus Pharmacology. Journal of pineal research, 39(2):215-216.
  • Reiter RJ, Tamura H, Tan DX, Xu X-Y, 2014a. Melatonin and the Circadian System: Contributions to Successful Female Reproduction. Fertility and sterility, 102(2):321-328.
  • Reiter RJ, Tan D-X, Tamura H, Cruz MHC, Fuentes-Broto L, 2014b. Clinical Relevance of Melatonin in Ovarian and Placental Physiology: A Review. Gynecological Endocrinology, 30(2):83-89.
  • Reiter RJ, Tan DX, Korkmaz A, ROTales-Corral SA, 2014c. Melatonin and Stable Circadian Rhythms Optimize Maternal, Placental and Fetal Physiology. Human reproduction update, 20(2):293-307.
  • Salt A, Çenesiz M, Çenesiz S, 2017. Melatonin, Etkileri Ve Kullanım Alanları. Etlik Veteriner Mikrobiyoloji Dergisi, 28(1):7-12.
  • Sari I, Gumus E, Taskiran AS, Sokmensuer LK, 2020. Effect of ovarian stimulation on the expression of piRNA pathway proteins. PloS one,Doi: 10.1371/journal.pone.0232629.
  • Sato A, Otsu E, Negishi H, Utsunomiya T, Arima T, 2007. Aberrant DNA Methylation of Imprinted Loci in Superovulated Oocytes. Human reproduction, 22(1):26-35.
  • Schwartz NB, McCobmack C, 1972. Reproduction: Gonadal Function and Its Regulation. Annual review of physiology, 34(1):425-472.
  • Sharker MR, Sukhan ZP, Kim SC, Lee WK, Kho KH, 2020. Identification, Characterization, and Expression Analysis of a Serotonin Receptor Involved in the Reproductive Process of the Pacific Abalone, Haliotis Discus Hannai. Molecular biology reports, 47(1):555-567.
  • Sheng Y, Wang L, Liu XS, Montplaisir V, Tiberi M, Baltz JM et al., 2005. A Serotonin Receptor Antagonist Induces Oocyte Maturation in Both Frogs and Mice: Evidence That the Same G Protein‐Coupled Receptor Is Responsible for Maintaining Meiosis Arrest in Both Species. Journal of cellular physiology, 202(3):777-786.
  • Soares JM, Masana MI, Erşahin Ç, Dubocovich ML, 2003. Functional Melatonin Receptors in Rat Ovaries at Various Stages of the Estrous Cycle. Journal of Pharmacology and Experimental Therapeutics, 306(2):694-702.
  • Tamura H, Takasaki A, Taketani T, Tanabe M, Lee L, Tamura I et al., 2014. Melatonin and Female Reproduction. Journal of Obstetrics and Gynaecology Research, 40(1):1-11.
  • Tan DX, Manchester LC, Sainz RM, Mayo JC, Leon J, Hardeland R et al., 2005. Interactions between Melatonin and Nicotinamide Nucleotide: Nadh Preservation in Cells and in Cell‐Free Systems by Melatonin. Journal of pineal research, 39(2):185-194.
  • Tanaka E, Baba N, Toshida K, Suzuki K, 1993. Serotonin Stimulates Steroidogenesis in Rat Preovulatory Follicles: Involvement of 5-Ht2 Receptor. Life sciences, 53(7):563-570.
  • Tarumi W, Itoh MT, Suzuki N, 2014. Effects of 5α-Dihydrotestosterone and 17β-Estradiol on the Mouse Ovarian Follicle Development and Oocyte Maturation. PloS one, 9(6).
  • Terranova P, Uilenbroek JTJ, Saville L, Horst D, Nakamura Y, 1990. Serotonin Enhances Oestradiol Production by Hamster Preovulatory Follicles in Vitro: Effects of Experimentally Induced Atresia. Journal of endocrinology, 125(3):433-438.
  • Uysal F, Ozturk S, Akkoyunlu G, 2018. Superovulation alters DNA methyltransferase protein expression in mouse oocytes and early embryos. J Assist Reprod Genet, 35(3):503–513.
  • Valbuena D, Martin J, de Pablo JL, Remohı́ J, Pellicer A, Simón C, 2001. Increasing Levels of Estradiol Are Deleterious to Embryonic Implantation Because They Directly Affect the Embryo. Fertility and sterility, 76(5):962-968.
  • Van der Auwera I, D'Hooghe T, 2001. Superovulation of Female Mice Delays Embryonic and Fetal Development. Human Reproduction, 16(6):1237-1243.
  • Vardar MA, Çetın T, Burgut R, Demır C, 1993. Klomifen sitrat veya HMG/HCG ile indüklenen sikluslarda luteal fazın değerlendirilmesi: Kısa luteal faz, luteal faz yetmezliği. Kadın Doğum Dergisi, 9(2): 127-131
  • Vaseghi H, Mogheiseh A, Sepehrimanesh M, Kafi M, Nooranizadeh MH. Super pregnancy in a BALB/c mouse superovulated with PMSG. Lab Anim Res. 2017;33(3):280–282. doi:10.5625/lar.2017.33.3.280
  • Williams GM, Jeffrey AM, 2000. Oxidative DNA Damage: Endogenous and Chemically Induced. Regulatory Toxicology and Pharmacology, 32(3):283-292.
  • Yücel GN, Kaplanoğlu GT, Seymen CM, 2018. Karanlığın Mucizesi: Melatonin Ve Ovaryum Etkileşimi. Dicle Tıp Dergisi, 45(1):85-92.

Effect of Different Doses of Exogenous Gonadotropin Administration on Serotonin and Melatonin Levels

Yıl 2020, Cilt 10, Sayı 3, 1566 - 1575, 01.09.2020
https://doi.org/10.21597/jist.707835

Öz

Ovarian stimulation (OS) by exogenous gonadotropins is a common technique both in experimental studies on reproductive biology and in vitro fertilization (IVF). However, the data obtained from some studies indicate that OS may have various negative effects on the quality of oocyte and embryo, and embryogenesis processes. Therefore, it is thought that further studies are needed to examine the possible effects of OS procedures on reproductive and other biological processes. It is reported that serotonin and melatonin are important hormones that have effects on the quality of oocyte and embryo. On the other hand, it is understood that there is no study to examine the effect of different doses of exogenous gonadotropin treatment on these hormones. Therefore, in this study, we aimed to examine the effects of different doses of exogenous gonadotropin on serotonin and melatonin levels in the mouse model.In our study, mice were divided into 4 different groups (n = 6) to treatment with 5, 7.5, 10 and 12.5 I.U. Pregnant Mare Serum Gonadotrophin/ Human Chorionic Gonadotropin ( PMSG/hCG). After the treatment with exogenous gonadotropins, levels of melatonin and serotonin were determined by the ELISA method in the plasma samples of the study groups. While there was no significant difference between the groups in terms of melatonin levels, there was a significant difference between the groups in terms of serotonin levels. In intragroup comparisons, it was found that there was a significant increase in the serotonin levels in the group treated with 7.5 IU PMSG/hCG compared to other groups.In conclusion, it is understood that the exogenous gonadotropin doses, which we administrated, did not affect melatonin levels but significantly increased serotonin levels after 7.5 I.U. PMSG/hCG administration compared to other doses. Additional studies to examine the effect of higher exogenous gonadotropin doses on these hormones in animals and also in humans, are thought to contribute to reproductive biology.

Kaynakça

  • Agarwal A, Gupta S, Sikka S, 2006. The Role of Free Radicals and Antioxidants in Reproduction. Current Opinion in Obstetrics and Gynecology, 18(3):325-332.
  • Amireault P, Dubé F, 2005. Serotonin and Its Antidepressant-Sensitive Transport in Mouse Cumulus-Oocyte Complexes and Early Embryos. Biology of reproduction, 73(2):358-365.
  • Baart EB, Martini E, van den Berg I, Macklon N, Galjaard RH, Fauser B et al., 2006. Preimplantation Genetic Screening Reveals a High Incidence of Aneuploidy and Mosaicism in Embryos from Young Women Undergoing Ivf. Human Reproduction, 21(1):223-233.
  • Battista P, Condon W, 1986. Serotonin-Induced Stimulation of Progesterone Production by Cow Luteal Cells in Vitro. Reproduction, 76(1):231-238.
  • Battista P, Rexroad Jr C, Condon W, 1987. Mechanisms Inveolved in the Action of Serotonin-Induced Stimulation of Progesterone Production by Bovine Luteal Cells in Viitro. Molecular and cellular endocrinology, 51(1-2):145-151.
  • Boden MJ, Varcoe TJ, Kennaway DJ, 2013. Circadian Regulation of Reproduction: From Gamete to Offspring. Progress in biophysics and molecular biology, 113(3):387-397.
  • Bodis J, Bognàr B, Hartmann G, Török A, Csaba I, 1992. Measurement of Noradrenaline, Dopamine and Serotonin Contents in Follicular Fluid of Human Graafian Follicles after Superovulation Treatment. Gynecologic and obstetric investigation, 33(3):165-167.
  • Bodis J, Hartmann G, Tinneberg H-R, Török A, Hanf V, Papenfuss F et al., 1993. Relationship between the Monoamine, Progesterone and Estradiol Content in Follicular Fluid of Preovulatory Graafian Follicles after Superovulation Treatment. Gynecologic and obstetric investigation, 35(4):232-235.
  • Bódis J, Török A, Tinneberg H-R, Hanf V, Hamori M, Cledon P, 1992. Influence of Serotonin on Progesterone and Estradiol Secretion of Cultured Human Granulosa Cells. Fertility and sterility, 57(5):1008-1011.
  • Bódis J, Sulyok E, Kőszegi T, Prémusz V, Várnagy Á, Koppán M, 2019. Serum and Follicular Fluid Levels of Serotonin, Kisspeptin, and Brain-Derived Neurotrophic Factor in Patients Undergoing in Vitro Fertilization: An Observational Study: Neurohormones in Patients Receiving Ivf. Journal of International Medical Research:0300060519879330.
  • Ceinos R, Chansard M, Revel F, Calgari C, Miguez J, Simonneaux V, 2004. Analysis of Adrenergic Regulation of Melatonin Synthesis in Siberian Hamster Pineal Emphasizes the Role of Hiomt. NeuROTignals, 13(6):308-317.
  • Chenette PE, Sauer MV, Paulson RJ, 1990. Very high serum estradiol levels are not detrimental to clinical outcome of in vitro fertilization. Fertil Steril, 54(5):858–863.
  • Clausell D, Soliman K, 1978. Ovarian Serotonin Content in Relation to Ovulation. Experientia, 34(3):410-411.
  • Combelles Catherine MH, ve Albertini DF, 2003. Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse." Biology of Reproduction, 68(3):812-21.
  • Cooke MS, Evans MD, Dizdaroglu M, Lunec J, 2003. Oxidative DNA Damage: Mechanisms, Mutation, and Disease. The FASEB Journal, 17(10):1195-1214.
  • Ertzeid G, Storeng R, 2001. The Impact of Ovarian Stimulation on Implantation and Fetal Development in Mice. Human Reproduction, 16(2):221-225.
  • Espino J, Macedo M, Lozano G, Ortiz Á, Rodríguez C, Rodríguez AB et al., 2019. Impact of Melatonin Supplementation in Women with Unexplained Infertility Undergoing Fertility Treatment. Antioxidants, 8(9):338.
  • Forman R, Belaisch-Allart J, Fries N, Hazout A, Testart J, Frydman R, 1988. Evidence for an Adverse Effect of Elevated Serum Estradiol Concentrations on Embryo Implantation. Fertility and sterility, 49(1):118-122.
  • Ganguly S, Coon SL, Klein DC, 2002. Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell and tissue research, 309(1):127-137.
  • Gelety TJ, Buyalos RP, 1995. The influence of supraphysiologic estradiol levels on human nidation. J Assist Reprod Genet. 12(7):406–412.
  • Goldman B 2007. Reproductive Medicine: The First Cut: Nature Publishing Group.
  • Graveleau C, Paust H-J, Schmidt-Grimminger D, Mukhopadhyay AK, 2000. Presence of a 5-Ht7 Receptor Positively Coupled to Adenylate Cyclase Activation in Human Granulosa-Lutein Cells. The Journal of Clinical Endocrinology & Metabolism, 85(3):1277-1286.
  • Group IW 1998. Art into Science: Regulation of Fertility Techniques: Islat Working Group: American Association for the Advancement of Science.
  • Iwamatsu T, Toya Y, Sakai N, Terada Y, Nagata R, Nagahama Y, 1993. Effect of 5‐Hydroxytryptamine on Steroidogenesis and Oocyte Maturation in Pre‐Ovulatory Follicles of the Medaka Oryzias Latipes: (Medaka/Steroidogenesis/5‐Hydroxytryptamine/Foillicle/Oocyte Maturation). Development, growth & differentiation, 35(6):625-630.
  • Kandemir YB, Aydin C, Gorgisen G, 2017. The Effects of Melatonin on Oxidative Stress and Prevention of Primordial Follicle Loss Via Activation of Mtor Pathway in the Rat Ovary. Cell Mol Biol(Noisy le Grand), 63(100-106.
  • Kara M, Kutlu T, Soguoglu K, Devranoglu B, Cetinkaya T. 2012. Association between serum estradiol level on the hCG administration day and IVF-ICSI outcome. Iran J Reprod Med, 10(1):53–58.
  • Kierszenbaum AL, 2006. Histoloji Ve Hücre Biyolojisi. Ankara, Palme Yayıncılık.
  • Koçak A, Çolak A, 1996. Melatonin Ve Santral Sinir Sistemi. J Turgut Özal Medical Center, 3(237-244.
  • Kondapalli LA, Molinaro TA, Sammel DA, 2012. A decrease in serum estradiol levels after human chorionic gonadotrophin administration predicts significantly lower clinical pregnancy and live birth rates in vitro fertilization cycles. Hum Reprod, 27(9):2690–2697.
  • Koppan M, Bodis J, Verzar Z, Tinneberg H-R, Torok A, 2004. Serotonin May Alter the Pattern of Gonadotropin-Induced Progesterone Release of Human Granulosa Cells in Superfusion System. Endocrine, 24(2):155-159.
  • Lewiński A, Szymczykiewicz P, Sewerynek E, Wajs E, 1993. Effects of Pinealectomy and Melatonin Administration on Certain Indices of Ovarian Hyperplasia and/or Hypertrophy in Rats with Both Ovaries Intact or after Unilateral Ovariectomy. Joal of pineal research, 14(3):117-127.
  • Li S, Pelletier G, 1995. Involvement of Serotonin in the Regulation of Gnrh Gene Expression in the Male Rat Brain. Neuropeptides, 29(1):21-25.
  • Lv Y, Li Y, Li J, Bian C, Qin C, Shi Q, 2020. A comparative genomics study on the molecular evolution of serotonin/melatonin biosynthesizing enzymes in vertebrates. Frontiers in Molecular Biosciences, 7.
  • Nikitina L, Buznikov G, Galanov AY, Malchenko LA, Trubnikova OB, 2002. The Control of Oocyte Maturation in the Starfish and Amphibians by Serotonin and Its Antagonists. International Journal of Developmental Biology, 37(2):363-364.
  • Ozturk S, Yaba-Ucar A, Sozen B, Mutlu D, Demir N, 2016. Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos. ReprodFertil Dev, 28(3):375–383.
  • Prasad P, Ogawa S, Parhar I (2015). Role of Serotonin in Fish Reproduction. Front. NeuROTci. 9, 1e9.
  • Rehman R, Hussain Z, Faraz N, 2012. Effect of estradiol levels on pregnancy outcome in obese females. J Ayub Med Coll Abbottabad, 24(3):3–5.
  • Reiter RJ, 1993. The Melatonin Rhythm: Both a Clock and a Calendar. Experientia, 49(8):654-664.
  • Reiter RJ, Tan DX, Maldonado MD, 2005. Melatonin as an Antioxidant: Physiology Versus Pharmacology. Journal of pineal research, 39(2):215-216.
  • Reiter RJ, Tamura H, Tan DX, Xu X-Y, 2014a. Melatonin and the Circadian System: Contributions to Successful Female Reproduction. Fertility and sterility, 102(2):321-328.
  • Reiter RJ, Tan D-X, Tamura H, Cruz MHC, Fuentes-Broto L, 2014b. Clinical Relevance of Melatonin in Ovarian and Placental Physiology: A Review. Gynecological Endocrinology, 30(2):83-89.
  • Reiter RJ, Tan DX, Korkmaz A, ROTales-Corral SA, 2014c. Melatonin and Stable Circadian Rhythms Optimize Maternal, Placental and Fetal Physiology. Human reproduction update, 20(2):293-307.
  • Salt A, Çenesiz M, Çenesiz S, 2017. Melatonin, Etkileri Ve Kullanım Alanları. Etlik Veteriner Mikrobiyoloji Dergisi, 28(1):7-12.
  • Sari I, Gumus E, Taskiran AS, Sokmensuer LK, 2020. Effect of ovarian stimulation on the expression of piRNA pathway proteins. PloS one,Doi: 10.1371/journal.pone.0232629.
  • Sato A, Otsu E, Negishi H, Utsunomiya T, Arima T, 2007. Aberrant DNA Methylation of Imprinted Loci in Superovulated Oocytes. Human reproduction, 22(1):26-35.
  • Schwartz NB, McCobmack C, 1972. Reproduction: Gonadal Function and Its Regulation. Annual review of physiology, 34(1):425-472.
  • Sharker MR, Sukhan ZP, Kim SC, Lee WK, Kho KH, 2020. Identification, Characterization, and Expression Analysis of a Serotonin Receptor Involved in the Reproductive Process of the Pacific Abalone, Haliotis Discus Hannai. Molecular biology reports, 47(1):555-567.
  • Sheng Y, Wang L, Liu XS, Montplaisir V, Tiberi M, Baltz JM et al., 2005. A Serotonin Receptor Antagonist Induces Oocyte Maturation in Both Frogs and Mice: Evidence That the Same G Protein‐Coupled Receptor Is Responsible for Maintaining Meiosis Arrest in Both Species. Journal of cellular physiology, 202(3):777-786.
  • Soares JM, Masana MI, Erşahin Ç, Dubocovich ML, 2003. Functional Melatonin Receptors in Rat Ovaries at Various Stages of the Estrous Cycle. Journal of Pharmacology and Experimental Therapeutics, 306(2):694-702.
  • Tamura H, Takasaki A, Taketani T, Tanabe M, Lee L, Tamura I et al., 2014. Melatonin and Female Reproduction. Journal of Obstetrics and Gynaecology Research, 40(1):1-11.
  • Tan DX, Manchester LC, Sainz RM, Mayo JC, Leon J, Hardeland R et al., 2005. Interactions between Melatonin and Nicotinamide Nucleotide: Nadh Preservation in Cells and in Cell‐Free Systems by Melatonin. Journal of pineal research, 39(2):185-194.
  • Tanaka E, Baba N, Toshida K, Suzuki K, 1993. Serotonin Stimulates Steroidogenesis in Rat Preovulatory Follicles: Involvement of 5-Ht2 Receptor. Life sciences, 53(7):563-570.
  • Tarumi W, Itoh MT, Suzuki N, 2014. Effects of 5α-Dihydrotestosterone and 17β-Estradiol on the Mouse Ovarian Follicle Development and Oocyte Maturation. PloS one, 9(6).
  • Terranova P, Uilenbroek JTJ, Saville L, Horst D, Nakamura Y, 1990. Serotonin Enhances Oestradiol Production by Hamster Preovulatory Follicles in Vitro: Effects of Experimentally Induced Atresia. Journal of endocrinology, 125(3):433-438.
  • Uysal F, Ozturk S, Akkoyunlu G, 2018. Superovulation alters DNA methyltransferase protein expression in mouse oocytes and early embryos. J Assist Reprod Genet, 35(3):503–513.
  • Valbuena D, Martin J, de Pablo JL, Remohı́ J, Pellicer A, Simón C, 2001. Increasing Levels of Estradiol Are Deleterious to Embryonic Implantation Because They Directly Affect the Embryo. Fertility and sterility, 76(5):962-968.
  • Van der Auwera I, D'Hooghe T, 2001. Superovulation of Female Mice Delays Embryonic and Fetal Development. Human Reproduction, 16(6):1237-1243.
  • Vardar MA, Çetın T, Burgut R, Demır C, 1993. Klomifen sitrat veya HMG/HCG ile indüklenen sikluslarda luteal fazın değerlendirilmesi: Kısa luteal faz, luteal faz yetmezliği. Kadın Doğum Dergisi, 9(2): 127-131
  • Vaseghi H, Mogheiseh A, Sepehrimanesh M, Kafi M, Nooranizadeh MH. Super pregnancy in a BALB/c mouse superovulated with PMSG. Lab Anim Res. 2017;33(3):280–282. doi:10.5625/lar.2017.33.3.280
  • Williams GM, Jeffrey AM, 2000. Oxidative DNA Damage: Endogenous and Chemically Induced. Regulatory Toxicology and Pharmacology, 32(3):283-292.
  • Yücel GN, Kaplanoğlu GT, Seymen CM, 2018. Karanlığın Mucizesi: Melatonin Ve Ovaryum Etkileşimi. Dicle Tıp Dergisi, 45(1):85-92.

Ayrıntılar

Birincil Dil Türkçe
Konular Biyoloji
Yayınlanma Tarihi Eylül-2020
Bölüm Biyoloji / Biology
Yazarlar

İsmail SARI (Sorumlu Yazar)
NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI
0000-0003-3732-2102
Türkiye


Erkan GÜMÜŞ
AYDIN ADNAN MENDERES ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, HİSTOLOJİ Ve EMBRİYOLOJİ ABD
0000-0001-6432-7457
Türkiye


Esma ÖZMEN
NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ABD
0000-0003-3223-6854
Türkiye


Inayet GUNTURK
NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, NİĞDE ZÜBEYDE HANIM SAĞLIK YÜKSEKOKULU, EBELİK ABD,
0000-0002-8299-1359
Türkiye


Serpil ERŞAN
NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ,TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ABD
0000-0002-8968-4044
Türkiye


Gönül Şeyda SEYDEL
NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, NİĞDE ZÜBEYDE HANIM SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU, YAŞLI BAKIMI ABD,
0000-0001-9317-0719
Türkiye

Yayımlanma Tarihi 1 Eylül 2020
Başvuru Tarihi 23 Mart 2020
Kabul Tarihi 1 Mayıs 2020
Yayınlandığı Sayı Yıl 2020, Cilt 10, Sayı 3

Kaynak Göster

Bibtex @araştırma makalesi { jist707835, journal = {Journal of the Institute of Science and Technology}, issn = {2146-0574}, eissn = {2536-4618}, address = {}, publisher = {Iğdır Üniversitesi}, year = {2020}, volume = {10}, pages = {1566 - 1575}, doi = {10.21597/jist.707835}, title = {Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi}, key = {cite}, author = {Sarı, İsmail and Gümüş, Erkan and Özmen, Esma and Gunturk, Inayet and Erşan, Serpil and Seydel, Gönül Şeyda} }
APA Sarı, İ. , Gümüş, E. , Özmen, E. , Gunturk, I. , Erşan, S. & Seydel, G. Ş. (2020). Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi . Journal of the Institute of Science and Technology , 10 (3) , 1566-1575 . DOI: 10.21597/jist.707835
MLA Sarı, İ. , Gümüş, E. , Özmen, E. , Gunturk, I. , Erşan, S. , Seydel, G. Ş. "Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi" . Journal of the Institute of Science and Technology 10 (2020 ): 1566-1575 <https://dergipark.org.tr/tr/pub/jist/issue/56289/707835>
Chicago Sarı, İ. , Gümüş, E. , Özmen, E. , Gunturk, I. , Erşan, S. , Seydel, G. Ş. "Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi". Journal of the Institute of Science and Technology 10 (2020 ): 1566-1575
RIS TY - JOUR T1 - Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi AU - İsmail Sarı , Erkan Gümüş , Esma Özmen , Inayet Gunturk , Serpil Erşan , Gönül Şeyda Seydel Y1 - 2020 PY - 2020 N1 - doi: 10.21597/jist.707835 DO - 10.21597/jist.707835 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 1566 EP - 1575 VL - 10 IS - 3 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.707835 UR - https://doi.org/10.21597/jist.707835 Y2 - 2020 ER -
EndNote %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi %A İsmail Sarı , Erkan Gümüş , Esma Özmen , Inayet Gunturk , Serpil Erşan , Gönül Şeyda Seydel %T Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi %D 2020 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 10 %N 3 %R doi: 10.21597/jist.707835 %U 10.21597/jist.707835
ISNAD Sarı, İsmail , Gümüş, Erkan , Özmen, Esma , Gunturk, Inayet , Erşan, Serpil , Seydel, Gönül Şeyda . "Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi". Journal of the Institute of Science and Technology 10 / 3 (Eylül 2020): 1566-1575 . https://doi.org/10.21597/jist.707835
AMA Sarı İ. , Gümüş E. , Özmen E. , Gunturk I. , Erşan S. , Seydel G. Ş. Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi. Iğdır Üniv. Fen Bil Enst. Der.. 2020; 10(3): 1566-1575.
Vancouver Sarı İ. , Gümüş E. , Özmen E. , Gunturk I. , Erşan S. , Seydel G. Ş. Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi. Journal of the Institute of Science and Technology. 2020; 10(3): 1566-1575.
IEEE İ. Sarı , E. Gümüş , E. Özmen , I. Gunturk , S. Erşan ve G. Ş. Seydel , "Farklı Dozlarda Ekzojen Gonadotropin Uygulamasının Serotonin ve Melatonin Düzeylerine Etkisi", Journal of the Institute of Science and Technology, c. 10, sayı. 3, ss. 1566-1575, Eyl. 2020, doi:10.21597/jist.707835