Cu Nanoparçacık İçeren Polikaprolakton Nanofiberlerin Antimikrobiyal Aktiviteleri

Yıl 2023, Cilt: 13 Sayı: 3, 1937 - 1945, 01.09.2023

Menekse Sakir , Nuri Burak Kiremitler , Ahmet Ceylan

https://doi.org/10.21597/jist.1264352

Öz

Askorbik asit ve CTAC yardımı ile ıslak kimyasal yöntem kullanılarak Cu nanoparçacıkların sentezi başarılı bir şekilde gerçekleştirildi. Elektron mikroskobu ile morfolojileri karakterize edilen nanoparçacıkların 578 nm civarında bir absorbans bandına sahip olduğu görüldü. Polikaprolakton (PCL) içerisine homojen bir şekilde dağıtılan Cu nanoparçacıklar ile elektroeğirme yöntemiyle ortalama 624±216 nm çapında nanofiberler elde edildi. PCL/Cu nanofiberlerin Staphylococcus aureus ve Escherichia coli bakterileri ile Candida albicans türü üzerindeki antimikrobiyal aktiviteleri incelendi. Nanolifler, sahip oldukları yüksek yüzey alanı sayesinde kontrol örnekleri ile kıyaslanabilir bir antimikrobiyal zon çaplarına sahip oldukları görüldü. Elde edilen PCL/Cu nanofiberlerin açık yaralarda kullanılan yara bandı veya bandaj gibi malzemelere, tıbbi tekstil ürünlerine entegre edilerek antimikrobiyal aktivitenin engellenmesi açısında faydalı olacağı düşünülmektedir.

Anahtar Kelimeler

Cu nanoparçacık, Polikaprolakton, Staphylococcus aureus, Escherichia coli, Antimikrobiyal aktivite

Antimicrobial Activities of Polycaprolactone Nanofibers Containing Cu Nanoparticles

Öz

The synthesis of Cu nanoparticles was carried out successfully using the wet chemical method with the help of ascorbic acid and CTAC. It was observed that the nanoparticles, whose morphology was characterized by electron microscopy, had an absorbance band of around 578 nm. Nanofibers with an average diameter of 624±216 nm were obtained by electrospinning with Cu nanoparticles homogeneously dispersed in polycaprolactone (PCL). Antimicrobial activities of PCL/Cu nanofibers on Staphylococcus aureus and Escherichia coli bacteria and Candida albicans were investigated. The nanofibers were found to have an antimicrobial zone diameter comparable to the control samples, thanks to their high surface area. The obtained PCL/Cu nanofibers are thought to be useful in preventing antimicrobial activity by integrating into materials such as band-aids or bandages used in open wounds, and medical textiles.

Anahtar Kelimeler

Cu nanoparticles, Polycaprolactone, Staphylococcus aureus, Escherichia coli, Antimicrobial activity

Kaynakça

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