Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara

Mustafa Çiçek; Esra Çiçek; Aytaç Kocabaş

doi:10.21597/jist.1522694

Derleme

Ectoine: From Microbial Survival Secret to Biotechnological Applications

Yıl 2025, Cilt: 15 Sayı: 1, 92 - 109, 01.03.2025

Mustafa Çiçek , Esra Çiçek , Aytaç Kocabaş

https://doi.org/10.21597/jist.1522694

Öz

Ectoine, a compatible solute produced by physiologically and taxonomically diverse microorganism species in response to environmental stress factors such as high salinity or extreme temperatures, is a natural compound of great interest, especially in the fields of microbiology, biotechnology and environmental science. Numerous studies have been conducted to elucidate the processes underlying the cellular synthesis of ectoine, and to define its roles in stress adaptation. Ectoin, which attracted the attention of researchers due to its extraordinary biotechnological potential, finds widespread use in various sectors, especially in the cosmetic and pharmaceutical industries. While this situation accelerates studies on the discovery of new species with high ectoine production potential, it also encourages the development of cost-effective and sustainable methods for large-scale ectoine production strategies from microbial sources. This review provides a comprehensive overview of ectoine's current areas of application, highlighting its evolving role in various industries and positioning ectoine as a versatile and effective compound with far-reaching effects.

Anahtar Kelimeler

Pharmaceuticals, Cosmetics, Stress adaptation, Compatible solute

Kaynakça

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Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara

Yıl 2025, Cilt: 15 Sayı: 1, 92 - 109, 01.03.2025

Mustafa Çiçek , Esra Çiçek , Aytaç Kocabaş

https://doi.org/10.21597/jist.1522694

Öz

Fizyolojik ve taksonomik açıdan oldukça büyük çeşitlilik sergileyen mikroorganizma türleri tarafından yüksek tuzluluk veya aşırı sıcaklık gibi çevresel stres faktörlerine yanıt olarak üretilen uyumlu çözünenlerden olan ektoin, özellikle mikrobiyoloji, biyoteknoloji ve çevre bilimi alanlarında büyük ilgi gören doğal bir bileşiktir. Olumsuz koşullar altında hücresel bütünlüğün ve işlevselliğin korunması açısından oldukça kritik bir molekül olan ektoinin hücresel sentezinin arkasında yatan mekanizmaların aydınlatılmasına ve stres adaptasyonundaki rollerinin tanımlanmasına yönelik pek çok çalışma gerçekleştirilmiştir. Sergilediği olağanüstü biyoteknolojik potansiyele bağlı olarak araştırmacıların dikkatini çeken ektoin başta kozmetik ve ilaç endüstrileri olmak üzere çeşitli sektörlerde yaygın kullanım alanı bulmaktadır. Bu durum bir yandan yüksek ektoin üretim potansiyeline sahip yeni türlerin keşfedilmesine yönelik çalışmalara hız kazandırırken bir yandan da mikrobiyal kaynaklardan; uygun maliyetli ve sürdürülebilir yöntemlerle büyük ölçekli ektoin üretim stratejilerinin geliştirilmesini teşvik etmektedir. Bu inceleme, bir yandan ektoinin mevcut uygulama alanlarına kapsamlı bir genel bakış sunarak çeşitli endüstrilerde gelişen rolünü vurgulamakta bir yandan da ektoini geniş kapsamlı etkilere sahip çok yönlü ve etkili bir bileşik olarak konumlandırmaktadır.

Anahtar Kelimeler

İlaç, Kozmetik, Stres adaptasyonu, Uyumlu çözünen madde

Etik Beyan

Bu makalenin yazarları, bu çalışmada kullanılan materyal ve yöntemlerin etik kurul izni ve / veya yasal-özel izin gerektirmediğini beyan etmektedir.

Teşekkür

Makalenin inceleme ve değerlendirme aşamasında yapmış oldukları katkılardan dolayı editör ve hakem/hakemlere teşekkür ederiz.

Kaynakça

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Toplam 99 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Biyoişlem, Biyoüretim ve Biyoürünler
Bölüm	Biyoloji / Biology
Yazarlar	Mustafa Çiçek 0000-0002-7109-6500 Esra Çiçek 0000-0002-7364-4435 Aytaç Kocabaş 0000-0001-7622-1932
Erken Görünüm Tarihi	20 Şubat 2025
Yayımlanma Tarihi	1 Mart 2025
Gönderilme Tarihi	26 Temmuz 2024
Kabul Tarihi	25 Kasım 2024
Yayımlandığı Sayı	Yıl 2025 Cilt: 15 Sayı: 1

Kaynak Göster

APA	Çiçek, M., Çiçek, E., & Kocabaş, A. (2025). Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara. Journal of the Institute of Science and Technology, 15(1), 92-109. https://doi.org/10.21597/jist.1522694
AMA	Çiçek M, Çiçek E, Kocabaş A. Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara. Iğdır Üniv. Fen Bil Enst. Der. Mart 2025;15(1):92-109. doi:10.21597/jist.1522694
Chicago	Çiçek, Mustafa, Esra Çiçek, ve Aytaç Kocabaş. “Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara”. Journal of the Institute of Science and Technology 15, sy. 1 (Mart 2025): 92-109. https://doi.org/10.21597/jist.1522694.
EndNote	Çiçek M, Çiçek E, Kocabaş A (01 Mart 2025) Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara. Journal of the Institute of Science and Technology 15 1 92–109.
IEEE	M. Çiçek, E. Çiçek, ve A. Kocabaş, “Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara”, Iğdır Üniv. Fen Bil Enst. Der., c. 15, sy. 1, ss. 92–109, 2025, doi: 10.21597/jist.1522694.
ISNAD	Çiçek, Mustafa vd. “Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara”. Journal of the Institute of Science and Technology 15/1 (Mart 2025), 92-109. https://doi.org/10.21597/jist.1522694.
JAMA	Çiçek M, Çiçek E, Kocabaş A. Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara. Iğdır Üniv. Fen Bil Enst. Der. 2025;15:92–109.
MLA	Çiçek, Mustafa vd. “Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara”. Journal of the Institute of Science and Technology, c. 15, sy. 1, 2025, ss. 92-109, doi:10.21597/jist.1522694.
Vancouver	Çiçek M, Çiçek E, Kocabaş A. Ektoin: Mikrobiyal Hayatta Kalma Sırrından Biyoteknolojik Uygulamalara. Iğdır Üniv. Fen Bil Enst. Der. 2025;15(1):92-109.

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