Tavşan Koksidiyozunda Tedavi ve Profilaksi

Öz

Koksidiyoz, tavşanlarda sağlık ve performans için önemli bir hastalık olup yem alımını, yemlerin sindirilebilirliğini ve üreme performansını etkileyen Eimeria türü parazitler tarafından oluşturulan önemli bir hastalıktır. Yüksek morbidite ve mortalite oranlarına neden olan koksidiyoz tavşanlarda vücuda alınan Eimeria türüne göre intestinal (E. intestinalis, E. irresidua, E. magna, E. perforans, E. media) ve hepatik koksidiyoz (E. stiedae) olarak ayrılır. Tavşanlarda hepatik koksidiyozun klinik belirtileri anoreksiya,alopesi, ishal, ikterik mukoza zarları, letarji, asites ve vücut ağırlığında önemli kayıplardır. İntestinal koksidiyozda ise villöz atrofinin yol açtığı besinlerin emilim bozukluğu, elektrolit dengesizliği, anemi, hipoproteinemi ve dehidrasyon nedeniyle kilo kaybına, ishale ve ölüme neden olur. Tedavide sıkı hijyenik önlemlerle birlikte anti-koksidiyal ilaçlar kullanılmaktadır. Ayrıca ilaçlara karşı direnç gelişmesi, yan etkiler, maliyet masrafları ve profilaktik ihtiyaçlardan dolayıson yıllarda çeşitli bitkisel ilaçlar, probiyotikler ve prebiyotiklerin araştırma konusu olduğu görülmektedir. Anti-koksidiyal bir ilacın etkili olabilmesi için tedavi edici özelliğinin yanı sıra proflaktik etkisinin de bulunması gerekmektedir. Bu derlemede tavşanlarda koksidiyoz hastalığına karşı tedavi ve profilaktik amaçla araştırılan anti-koksidiyal uygulamalar hakkında güncel bilgiler verilecektir.

Anahtar Kelimeler

• Koksidiyoz
• Tavşan
• Tedavi

Treatment and Prophylaxis in Rabbit Coccidiosis

Öz

Coccidiosis is an important disease for the health and performance of rabbits and is an important disease caused by Eimeria species parasites that affect feed intake, feed digestibility and reproductive performance. Coccidiosis, which causes high morbidityand mortality rates, is divided into intestinal (E. intestinalis, E. irresidua, E. magna, E. perforans, E. media) and hepatic coccidiosis (Eimeria stiedae) according to the type of Eimeria ingested in rabbits. Clinical manifestations of hepatic coccidiosis in rabbits are loss of appetite, anorexia, hair loss, diarrhea, yellowish mucous membranes, fatigue, ascites, and significant loss of body weight. In intestinal coccidiosis, it causes weight loss, diarrhea and death due to malabsorption of nutrients caused by villous atrophy, electrolyte imbalance, anemia, hypoproteinemia and dehydration. Anti-coccidial drugs are used accompanied by strict hygienic measures in the treatment. Various herbal medicines, probiotics and prebiotics have further been the subjectof research in recent years due to the development of resistance to drugs, side effects, cost expense and prophylactic needs. In order for an anti-coccidial drug be effective, it must have prophylactic effect as well as its therapeutic feature. In this review, current knowledge will be given about anti-coccidial administrations investigated for therapeutic and prophylactic purposes against coccidiosis in rabbits.

Anahtar Kelimeler

• Coccidiosis
• Rabbit
• Treatment

Kaynakça

1. 1.Abbas, A., Iqbal, Z., Abbas, R. Z., Khan, M. K., Khan, J. A., Mahmood, M. S., et al. (2017). In vivo anticoccidial effects of Beta vulgaris (sugar beet) in broiler chickens. Microbial pathogenesis, 111, 139-144.
2. 2.Abd El Megid, A. D., Khaled, M., Emam, M. A., & Adel, A. (2018). Biochemical role of zinc oxide and propolis nanoparticles in protection rabbits against coccidiosis. Benha Veterinary Medical Journal, 34(1), 314-328.
3. 3.Aboelhadid, S. M., El-Ashram, S., Hassan, K. M., Arafa, W. M., & Darwish, A. B. (2019). Hepato-protective effect of curcumin and silymarin against Eimeria stiedae in experimentally infected rabbits. Livestock Science, 221, 33-38.
4. 4.Aboelhadid, S. M., Hashem, S., Abdel-Kafy, E.-S., Mahrous, L. N., Farghly, E. M., Abdel-Baki, A.-A. S., et al. (2021). Prebiotic supplementation effect on Escherichia coli and Salmonella species associated with experimentally induced intestinal coccidiosis in rabbits. PeerJ, 9, e10714.
5. 5.Abu El Ezz, N., Aboelsoued, D., Hassan, S., Abdel Megeed, K., & El-Metenawy, T. (2020). Therapeutic effect of Moringa oleifera and Thymus vulgaris oils against hepatic coccidiosis in experimentally infected rabbits. Tropical Biomedicine, 37(4), 1018-1028.
6. 6.Ayan, A., Ahmed, I., Khan, J. M., Munir, S., Hussain, M., Khan, A. K., et al. (2020). Hematological changes and comparative efficacy of allopathic and herbal drugs on coccidiosis in rabbits. Baltica, 33(2), 78-99.
7. 7.Benato L, Hastie P, O'Shaughnessy P, Murray JA, Meredith A. Effects of probiotic Enterococcus faecium and Saccharomyces cerevisiae on the faecal microflora of pet rabbits. J Small Anim Pract. 2014 Sep;55(9):442-6.
8. 8.Çam, Y., Atasever, A., Eraslan, G., Kibar, M., Atalay, Ö., Beyaz, L., et al. (2008). Eimeria stiedae: experimental infection in rabbits and the effect of treatment with toltrazuril and ivermectin. Experimental parasitology, 119(1), 164-172.

9. 9.Dorman, H. D., & Deans, S. G. (2000). Antimicrobial agents from plants: antibacterial activity of plant volatile oils. Journal of applied microbiology, 88(2), 308-316.
10. 10.El-Ashram, S. A., Aboelhadid, S. M., Abdel-Kafy, E.-S. M., Hashem, S. A., Mahrous, L. N., Farghly, E. M., et al. (2019). Prophylactic and therapeutic efficacy of prebiotic supplementation against intestinal coccidiosis in rabbits. Animals, 9(11), 965.
11. 11.El-Ghoneimy, A., & El-Shahawy, I. (2017). Evaluation of amprolium and toltrazuril efficacy in controlling natural intestinal rabbit coccidiosis. Iranian journal of veterinary research, 18(3), 164.
12. 12.Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterol Hepatol. 2017 Aug;14(8):491-502.
13. 13.Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterol Hepatol. 2014 Aug;11(8):506-14.
14. 14.Indrasanti, D., Indradji, M., Hastuti, S., Aprilliyani, E., Fatikha, F., & Rosyadi, K. (2017). The administration of garlic extract on Eimeria stiedai oocysts and the hematological profile of the coccidia infected rabbits. Media Peternakan, 40(3), 158-164.
15. 15.Jahangiri, F., Razavi, S., & Nazifi, S. (2018). Comparative effect of Melissa officinalis aqueous extract, sulfadimidine, and vitamin E–selenium on antioxidant parameters in rabbit experimental coccidiosis. Comparative Clinical Pathology, 27(2), 371-378.
16. 16.KN, A. M., NM, A. E., & Abdel-Rahman, E. H. (2005). Protective effect of Eimeria stiedae coproantigen against hepatic coccidiosis in rabbits. Journal of the Egyptian Society of Parasitology, 35(2), 581-595.
17. 17.Leone, A., Spada, A., Battezzati, A., Schiraldi, A., Aristil, J., & Bertoli, S. (2015). Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves: An overview. International journal of molecular sciences, 16(6), 12791-12835.
18. 18.Ogolla, K. O., Gathumbi, P. K., Waruiru, R. M., Okumu, P. O., Chebet, J.,& Kitala, P. M. (2018). Efficacy of sulphachloropyrazine, amprolium hydrochloride, trimethoprim-sulphamethoxazole, and diclazuril against experimental and natural rabbit coccidiosis. Journal of veterinary medicine, 2018.
19. 19.Pérez-Fonseca, A., Alcala-Canto, Y., Salem, A. Z., & Alberti-Navarro, A. B. (2016). Anticoccidial efficacy of naringenin and a grapefruit peel extract in growing lambs naturally-infected with Eimeria spp. Veterinary parasitology, 232, 58-65.
20. 20.Petrova, Y. (2019). Pasteurellosıs And Eımerıosıs–Worldwıde Problems In The Rabbıt Farms: A Revıew. Trakia Journal of Sciences, 17(1), 67.
21. 21.Pourali, M., Kermanshahi, H., Golian, A., Razmi, G. R., & Soukhtanloo, M. (2014). Antioxidant and anticoccidial effects of garlic powder and sulfur amino acids on Eimeria-infected and uninfected broiler chickens. Iranian Journal of Veterinary Research, 15(3), 227-232.
22. 22.Qamar, F., Sharif, R., Qamar, M., & Basharat, A. (2013). Comparative efficacy of sulphadimidine sodium, toltrazuril and amprolium for coccidiosis in rabbits. Science International (Lahore), 25(2), 295-298.
23. 23.Rasooli, I., Rezaei, M. B., & Allameh, A. (2006). Ultrastructural studies on antimicrobial efficacy of thyme essential oils on Listeria monocytogenes. International journal of infectious diseases, 10(3), 236-241.
24. 24.Rivero-Perez, N., Hernández-Alvarado, J. L., Valladares-Carranza, B., Delgadillo-Ruiz, L., Ojeda-Ramírez, D., Sosa-Gutiérrez, C. G., et al. (2019). Salix babylonica L. as a natural anticoccidial alternative in growing rabbits. Evidence-Based Complementary and Alternative Medicine, 2019.
25. 25.Sivajothi, S., Reddy, B. S., & Rayulu, V. (2014). Intestinal coccidiosis infection in domestic rabbits. International Journal of Biological Research, 2(2), 48-50.
26. 26.Sivajothi, S., Reddy, B. S., & Rayulu, V. (2016). Study on impression smears of hepatic coccidiosis in rabbits. Journal of Parasitic Diseases, 40(3), 906-909.
27. 27.Sorour, S. S., Abou Asa, S., Elhawary, N. M., Ghazy, E. W., Abd El Latif, A., El-Abasy, M. A., et al. (2018). Anticoccidial and hepatoprotective effects of artemisinin liquid extract, cinnamon essential oil and clove essential oil against Eimeria stiedae infection in rabbits. Tropical biomedicine, 35(4), 926-943.
28. 28.Worku, M., Franco, R., & Baldwin, K. (2009). Efficacy of garlic as an anthelmintic in adult Boer goats. Archives of Biological Sciences, 61(1), 135-140.