Naringin is a Possible Protective Agent in a Rat Model of Polymicrobial Sepsis

Öz

Objective: The current study aimed to investigate the potential protective effect, the levels of some inflammatory cytokines, and the activities of oxidative stress markers of naringin, which is a flavonoid, on a rat model of polymicrobial sepsis-induced kidney injury. Method: Thirty (n=30) Wistar albino rats were randomly divided into five groups. The inflammatory cytokine levels were measured by enzyme-linked immunosorbent assay technique. Oxidative stress parameters were measured by tissue biochemistry. Results: Cecal-ligation and puncture sepsis led to a dramatic increase in all pro-inflammatory cytokine levels, and naringin applications led to an important decrease in the levels of inflammatory cytokines in a dose-dependent manner. Additionally, naringin caused an increase in the enzyme activities of malondialdehyde and superoxide dismutase and a decrease in the level of glutathione. Conclusion: Natural products especially flavonoids have the potential to be a protective agent in sepsis-induced organ injury models. In our study, we preferred to use naringin as a natural agent and detected that it affected the inflammatory cytokine levels and oxidative stress enzyme activities. Further detailed studies should be performed to investigate the molecular mechanisms of the anti-inflammatory and antioxidant effects of naringin.

Anahtar Kelimeler

• İnflamasyon
• naringin
• oksidatif stres
• sıçan
• sepsis

Naringin is a Possible Protective Agent in a Rat Model of Polymicrobial Sepsis

Öz

Objective: The current study aimed to investigate the potential protective effect, the levels of some inflammatory cytokines, and the activities of oxidative stress markers of naringin, which is a flavonoid, on a rat model of polymicrobial sepsis-induced kidney injury. Method: Thirty (n=30) Wistar albino rats were randomly divided into five groups. The inflammatory cytokine levels were measured by enzyme-linked immunosorbent assay technique. Oxidative stress parameters were measured by tissue biochemistry. Results: Cecal-ligation and puncture sepsis led to a dramatic increase in all pro-inflammatory cytokine levels, and naringin applications led to an important decrease in the levels of inflammatory cytokines in a dose-dependent manner. Additionally, naringin caused an increase in the enzyme activities of malondialdehyde and superoxide dismutase and a decrease in the level of glutathione. Conclusion: Natural products especially flavonoids have the potential to be a protective agent in sepsis-induced organ injury models. In our study, we preferred to use naringin as a natural agent and detected that it affected the inflammatory cytokine levels and oxidative stress enzyme activities. Further detailed studies should be performed to investigate the molecular mechanisms of the anti-inflammatory and antioxidant effects of naringin.

Anahtar Kelimeler

• İnflamasyon
• naringin
• oksidatif stres
• sıçan
• sepsis

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