Sıçan Kuyruğu Kanama Modelleri: Kapsamlı Bir İnceleme

Öz

Amaçlar: Sıçan kuyruğu kanama modelleri, araştırmacılar tarafından potansiyel hemostatik ve antikoagülan ajanların etkinliğini değerlendirmek için sıklıkla tercih edilmektedir. Sık kullanılmalarına rağmen, farklı çalışmalar arasında metodoloji ve terminoloji açısından tutarsızlıklar bulunmaktadır. Hemostatik ve antikoagülan ajanlar kanama kaynaklı ölümleri azaltmada faydalı olduğundan, sıçan kuyruğu kanama modellerinin standardizasyonu araştırmanın güvenilirliği açısından çok önemlidir. Yöntemler: 2023 yılında, PUBMED veri tabanında "sıçan kuyruğu kanaması" sorgusu kullanılarak hedefli bir araştırma gerçekleştirilmiştir. Özellikle sıçan kuyruğu kanama modelleri kullanan çalışmaları belirlemek için 172 makalenin özetleri ve yöntemleri incelenmiş ve 70 ilgili makale seçilmiştir. Sonuçlar: Literatür taraması, aynı yöntemi kullanan çalışmalar ile aynı modeli uygulayan ve farklı adlandıran diğer çalışmalar arasında önemli farklılıklar olduğunu ortaya koymuştur. Ayrıca, kullanılan araçlar, kesi derinlikleri ve kanama değerlendirme tekniklerindeki farklılıklar, bu modellerin güvenilirliğini etkileyen tutarsızlıklara katkıda bulunmaktadır. Sonuçlar: Sıçan kuyruğu kanama modelleri hakkındaki literatürde tutarlılık ve standardizasyon eksikliği bulunmaktadır ve bu durum araştırmanın güvenilirliğini ve tekrarlanabilirliğini etkilemektedir. Birçok çalışmada aynı model için farklı isimler kullanılması, bazı araştırmacıları şaşırtabilir. Dahası, aynı modeli kullanan çalışmalar arasında bile metodoloji farklılıkları mevcuttur. Bu sorunları ele almak için, hemostatik ve antikoagülan ajanların değerlendirilmesinde önemli rol oynayan sıçan kuyruğu kanama modellerinin standardizasyonu gereklidir.

Anahtar Kelimeler

• Kanama
• Kanama Modelleri
• Sıçan Kuyruğu Kanama Modelleri
• Hemostaz
• Antikoagülan İlaçlar
• Hemostatik İlaçlar

Rat Tail Bleeding Models: A Comprehensive Review

Öz

Objectives: Rat tail bleeding models are commonly preferred by researchers for evaluating efficacy of potential hemostatic and anticoagulant agents. Although they are used frequently, there are inconsistencies in terms of methodology and terminology among different studies. As hemostatic and anticoagulant agents are useful to decrease deaths from bleeding, standardization of rat tail bleeding models is crucial for reliability of research. Methods: In 2023, a targeted research was performed in the PUBMED database using the query "rat tail bleeding". The abstracts and methods of 172 articles were examined to identify studies specifically using rat tail bleeding models and 70 relevant articles were selected. Results: Literature review revealed significant variations between studies using the same method including other studies implementing the same model and naming it differently. Additionally, differences in tools used, incision depths, and bleeding assessment techniques contribute to inconsistencies affecting reliability of these models. Conclusions: The literature on rat tail bleeding models lacks consistency and standardization, which affects the reliability and reproducibility of research. Many studies use different names for the same model, which can confuse some researchers. Furthermore, there are variations in methodology even among studies using the same model. To address these issues, standardization of rat tail bleeding models is necessary as they are essential for evaluating hemostatic and anticoagulant agents.

Anahtar Kelimeler

• Bleeding
• Bleeding Models
• Rat Tail Bleeding Models
• Hemostasis
• Anticoagulant Agents
• Hemostatic Agents

Kaynakça

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