Hayati Önemde Bir Balık: Hastalık Senaryolarında Zebra Balığı Modelinin Kullanıldığı Kritik Araştırmalar ve Vaka Raporlarının Taraması

Yıl 2024, Cilt: 4 Sayı: 2, 53 - 59, 19.09.2024

Nurdan Filik

https://doi.org/10.62425/jlasp.1426010

Öz

Geçen yüzyılın ve halen de tıbbi gelişmelerin neredeyse tamamı hayvanlar üzerinde yapılan araştırmalara dayalıdır. Zebra balığının okyanustan laboratuvara olan yolculuğu büyük bilimsel buluşlara yol açar. Zebra balığının şeffaf yapısı, iç yapılarının izlenmesine yardımcı olur ve bilim adamlarının balıklardaki nano parçacıkların etkilerini görmesine olanak tanır. Organları insanlarla aynı temel özellikleri paylaşıyor ve bu nedenle insanın gelişim süreçlerini incelemek için kullanılabilir. Zebra balığı genlerinin %70'i insanlarla uyum gösterir ve hastalığa bağlı genlerin %84'ü zebra balığı uyumuna sahiptir. Zebra balığı embriyolarının genetiği de değiştirilebilir. Zebra balığı gibi bazı balıklar, hasar görmüş retina sinir hücrelerini yenileyebilir. Zebra balığının retinasındaki Müller galia hücreleri, yaralanmaya yanıt olarak dönüşebilir ve retinayı yeniden büyütmek ve tüm hasarlı nöronları değiştirmek için kök hücreler gibi davranabilir. İnsanlar aynı Müller galia hücresine sahip olsalar da, hasara aynı şekilde tepki vermezler. Zebra balığı aynı zamanda genomlarının düzenlenmesine de oldukça duyarlıdır. Zebra balığı larva döneminde kalp gibi bazı dokuları yeniler. Ayrıca zebra balığı, ilaçların nasıl çalıştığı ve organizmanın vücuduna ne yaptığı gibi farmakolojiyi incelemek için bir hayvan modeli olarak kullanılıyor. Bu derlemenin amacı, burada, hücresel davranışlara ve moleküler mekanizmalara odaklanarak, in vivo modellerden elde edilen bulguları vurgulayarak ve doku hücre kültürü ve organoidlerdeki son gelişmeleri kısaca tartışarak, bu özelleşmiş yapıların ve model organizmanın nasıl olduğuna dair mevcut bilgileri gözden geçirmektir. Derleme, insan organoid hastalık modellerinin model organizma üzerindeki uygulamalarını tartışmakta ve hastalık tedavilerinin ana hatlarının altını çizmektedir..

Anahtar Kelimeler

Model organizma, Zebra balığı, Hastalık Senaryosu, Vaka raporu taraması, Hastalıkların kontrolü

Vital A Fish: A Critical Review of Zebrafish Models in Disease Scenario and Case Reports Screens

Öz

ABSTRACT
Virtually every major medical advance of the last century and at still has depended upon research with animals. Zebrafish's journey from the ocean to the laboratory leads to major scientific breakthroughs. Transparency structure of zebrafish helps in monitoring their internal structures and are permitting scientist to see effectes of nano particles in fish. Their organs share the same main features as humans and so can be used to study human developmental processes. Zebrafish congruence 70% of their genes with humans, and 84% of ailment-depended genes have zebrafish congruence. The zebrafish embryos can also genetically modified. Certain fishes like zebrafish are able to regenerate damaged retinal nerve cells. Müller galia cells in retina of zebrafish can transform in response to injury and act like stem cells to regrow the retina and replace all damaged neurons. Though humans have the same exact Müller galia cell, they don’t respond to damaged in the same way. Zebrafish are also very responsive to having their genomes edited. Zebrafish regenerate some tissue such as heart in during larval stage. In additionaly zebrafish are used as an animal model to study pharmocology – how drugs work and what they do to an organism’s body. Aim of this review, here, we review current knowledge of how these specialized structures and model organism by focusing on cellular behaviors and molecular mechanisms, highlighting findings from in vivo models and briefly discussing the recent advances in tissue cell culture and organoids. Review discusses the applications of human organoids models of disease on model organism and outlines the ailment treatments.

Anahtar Kelimeler

Model organism, Zebrafish, Disease scenario, Case report screen, Diseases controlling

Kaynakça

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