Anthelmintic Activity of Ethanol Extract of Polygonum minus Leaves against Ascaridia galli

Yıl 2018, Cilt: 08 Sayı: 01, 23 - 26, 15.03.2018

Dara Agusti Maulidya Muhammad Ibnu Kahtan Diana Natalia Mitra Handini Ari Vidiyantoro

https://doi.org/10.5799/jmid.403142

Öz

Anthelmintic Activity of Ethanol
Extract of Polygonum minus Leaves against
Ascaridia galli

Dara Agusti
Maulidya¹, Muhammad Ibnu Kahtan², Diana Natalia²,
Mitra Handini³, Ari Widiyantoro⁴

¹University of Tanjungpura, Faculty
of Medicine, Pontianak, West Kalimantan, Indonesia

²University of Tanjungpura, Faculty
of Medicine, Department of Parasitology, Pontianak, West Kalimantan, Indonesia

³University of Tanjungpura, Faculty
of Medicine, Department of Physiology, Pontianak, West Kalimantan, Indonesia

⁴University of Tanjungpura, Faculty
of Mathematics and Science, Department of Chemistry, Pontianak, West
Kalimantan, Indonesia

 

ABSTRACT

Objectives: Helminth infection is one of the main matters that
cause health problems in developing countries. Polygonum minus are empirically used as an anthelmintic drug, but
there has been no scientific study that proves it.

Methods: This
study was aimed at determining the anthelmintic activity of ethanol extract of Polygonum minus leaves against Ascaridia galli in vitro. The extract
was prepared in three different concentrations i.e 0.5 mg/mL, 1 mg/mL and 2
mg/mL. NaCl 0.9% was used as a negative control group and albendazole 0.2
mg/mL, a broad spectrum anthelmintic was used as a positive control group. Ascaridia galli was used as the test
parasite. The study involved the determination of death time of the worms.

Results: The
death time of the worms that caused by the extract concentration 0.5 mg/mL, 1
mg/mL and 2 mg/mL, respectively were (mean±SD) 35±3.32 hours, 32.8±2.39 hours
and 25±3.39 hours. The death time that caused by negative and positive control
group were 76.6±8.30 hours and 19.2±1.48 hours. There is no significant
difference of death time of the worms between the extract concentration 2 mg/mL
and the positive control group.

Conclusion: The anthelmintic activity of ethanol extract of Polygonum minus leaves has been
confirmed and extract concentration 2 mg/mL has the same anthelmintic activity
with albendazole 0.2 mg/mL. J Microbiol
Infect Dis 2018; 8(1):23-26

Keywords:
Anthelmintic, Polygonum minus, Ascaridia
galli, ascariasis

Anahtar Kelimeler

Anthelmintic, Polygonum minus, Ascaridia galli, ascariasis

Kaynakça

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