Klinik Araştırma
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Alcohol, Substance and Nicotine Use in Adults having Obsessive-Compulsive Disorder Comorbid with Tic Disorder

Yıl 2026, Cilt: 13 Sayı: 1 , 25 - 29 , 31.03.2026
https://doi.org/10.32739/jnbs.13.1.285
https://izlik.org/JA77RB74PC

Öz

Few studies have investigated the effect of tic disorder (TD) co-occurring with obsessive-compulsive disorder (OCD) on smoking, alcohol use disorders (AUD) and substance use disorders (SUD). We detected lifetime TD, smoking and AUD/SUD in 559 adults with OCD and questioned sociodemographic variables involving adult life including educational achievement, unemployment rate, marital status and suicide attempts (SA). Fifty-four patients (9.66%) had current or past TD. Individuals with and without TD had similar prevalence of AUD/SUD and smoking and similar severity of OCD, anxiety and depressive symptoms. OCD+TD group was characterized by early onset of OCD, male predominance and low percentage of the married. Years of education, unemployment rate and history of SA did not show any difference. TD accompanying OCD in adults has no aggravating impact on the severity of OCD, on predisposition to harmful substances, on educational attainment, unemployment rate, and history of SA whereas marital status is seriously influenced.

Kaynakça

  • 1. Kloft L, Steinel T, Kathmann N. Systematic review of co-occurring OCD and TD: Evidence for a tic-related OCD subtype? Neurosci Biobehav Rev 2018;95:280-314. doi: 10.1016/j.neubiorev.2018.09.021. https://www.sciencedirect.com/science/article/pii/S0149763417309740?via%3Dihub
  • 2. Eddy CM, Cavanna AE. Tourette syndrome and obsessive-compulsive disorder: Compulsivity along the continuum. J Obsessive Compuls Relat Disord 2014;3:363-71. doi:org/10.1016/j.jocrd.2014.04.003 https://www.sciencedirect.com/science/article/pii/S221136491400027X
  • 3. Virtanen S, Sidorchuk A, Fernández de la Cruz L, Brander G, Lichtenstein P, Latvala A, Mataix-Cols D. Association of Tourette syndrome and chronic tic disorder with subsequent risk of alcohol- or drug-related disorders, criminal convictions, and death: A population-based family study. Biol Psychiatry 2021;89(4):407-14. doi: 10.1016/j.biopsych.2020.09.014. https://www.sciencedirect.com/science/article/pii/S0006322320319223?via%3Dihub
  • 4. Cuzen NL, Stein DJ, Lochner C, Fineberg NA. Comorbidity of obsessive-compulsive disorder and substance use disorder: A new heuristic. Hum Psychopharmacol 2014;29:89–93. doi: 10.1002/hup.2373. https://onlinelibrary.wiley.com/doi/10.1002/hup.2373
  • 5. Tan, O. Is obsessive–Compulsive disorder preventive against addiction? JNBS 2021;8:251-61. doi: 10.4103/jnbs.jnbs_15_21 https://journals.lww.com/jons/Fulltext/2021/08030/Is_Obsessive_Compulsive_Disorder_Preventive.10.aspx
  • 6. Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, et al. The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 1989;28(4):566-73. doi: 10.1097/00004583-198907000-00015. https://www.sciencedirect.com/science/article/abs/pii/S0890856709654770?via%3Dihub
  • 7. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989;46(11):1006-11. doi: 10.1001/archpsyc.1989.01810110048007. https://jamanetwork.com/journals/jamapsychiatry/article-abstract/494743
  • 8. Williams JB. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988;45(8):742-7. doi: 10.1001/archpsyc.1988.01800320058007. https://jamanetwork.com/journals/jamapsychiatry/article-abstract/494356
  • 9. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 1988;56(6):893-7. doi: 10.1037//0022-006x.56.6.893. https://psycnet.apa.org/record/1989-10559-001
  • 10. Comings DE. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. I. Drug abuse. Drug Alcohol Depend 1994;35(1):1-16. doi: 10.1016/0376-8716(94)90104-x. https://www.sciencedirect.com/science/article/abs/pii/037687169490104X?via%3Dihub
  • 11. Comings DE. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. II. Alcohol abuse. Drug Alcohol Depend 1994;35(1):17-24. doi: 10.1016/0376-8716(94)90105-8. https://www.sciencedirect.com/science/article/abs/pii/037687169490104X?via%3Dihub
  • 12. Coffey BJ, Miguel EC, Biederman J, Baer L, Rauch SL, O'Sullivan RL, et al. Tourette's disorder with and without obsessive-compulsive disorder in adults: are they different? J Nerv Ment Dis 1988;186(4):201-16. doi: 10.1097/00005053-199804000-00001. https://journals.lww.com/jonmd/abstract/1998/04000/tourette_s_disorder_with_and_without.1.aspx
  • 13. Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA, Illmann C, et al. Tourette Syndrome Association International Consortium for Genetics. Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome. JAMA Psychiatry 2015;72(4):325-33. doi: 10.1001/jamapsychiatry.2014.2650. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2110028
  • 14. Andersen K, Groth C, Skov L, Debes NM. Childhood comorbidity severity impacts adolescent substance consumption in patients with Tourette syndrome. Pediatr Neurol 2023;145:88-93. doi: 10.1016/j.pediatrneurol.2023.05.004. https://www.sciencedirect.com/science/article/pii/S0887899423001479?via%3Dihub
  • 15. Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: Prevalence, phenomenology, comorbidities, and coexistent psychopathologies. Lancet Psychiatry 2015;2(1):68-87. doi: 10.1016/S2215-0366(14)00132-1. https://www.sciencedirect.com/science/article/abs/pii/S2215036614001321?via%3Dihub
  • 16. Garris J, Quigg M. The female Tourette patient: Sex differences in Tourette disorder. Neurosci Biobehav Rev 2021;129:261-268. doi: 10.1016/j.neubiorev.2021.08.001. https://www.sciencedirect.com/science/article/pii/S0149763421003432?via%3Dihub https://www.neurology.org/doi/10.1212/WNL.0000000000210249
  • 17. Dy-Hollins ME, Chibnik LB, Tracy NA, Osiecki L, Budman CL, Cath DC, et al. Sex differences in natural history and health outcomes among individuals with tic disorders. Neurology 2025;104(3):e210249. doi: 10.1212/WNL.0000000000210249.https://onlinelibrary.wiley.com/doi/10.1111/ene.70252
  • 18. Subramaniam M, Soh P, Vaingankar JA, Picco L, Chong SA. Quality of life in obsessive-compulsive disorder: Impact of the disorder and of treatment. CNS Drugs 2013;27(5):367-383. doi: 10.1007/s40263-013-0056-z.https://link.springer.com/article/10.1007/s40263-013-0056-z
  • 19. O'Hare D, Helmes E, Eapen V, Grove R, McBain K, Reece J. The impact of tic severity, comorbidity and peer attachment on quality of life outcomes and functioning in Tourette's syndrome: Parental perspectives. Child Psychiatry Hum Dev 2016;47(4):563-573. doi: 10.1007/s10578-015-0590-7. https://link.springer.com/article/10.1007/s10578-015-0590-7
  • 20. Pring K, Malli M, Hardy BW, Rapp SR, Storch EA, et al. Reframing stigma in Tourette syndrome: An updated scoping review. Eur Child Adolesc Psychiatry 2025;34(1):19-39. doi: 10.1007/s00787-023-02332-3. https://link.springer.com/article/10.1007/s00787-023-02332-3
  • 21. Feehan A, Colozzo P, Pritchard L, Smith V, Charest M. Communication and psychosocial functioning in children with Tourette syndrome: Parent-reported measures. Int J Lang Commun Disord 2025;60(4):e70056. doi: 10.1111/1460-6984.70056. https://onlinelibrary.wiley.com/doi/full/10.1111/1460-6984.70056
  • 22. Martindale JM, Chapman L, Carson AJ, Reilly K, Malli M, Storch EA, et al. Beyond the tics: Experiences of stigma and psychosocial impact in Tourette syndrome. Child Psychiatry Hum Dev 2026. doi: 10.1007/s10578-026-01965-0.https://link.springer.com/article/10.1007/s10578-026-01965-0
  • 23. United Nations, Department of Economic and Social Affairs, Population Division. World Marriage Data 2019. Available at: https://www.un.org/development/desa/pd/data/world-marriage-data
  • 24. Turkish Statistical Institute (TÜİK). Marriage Statistics. Available at: https://web.archive.org/web/20150721230539/http://rapory.tuik.gov.tr/19-07-2015-20%3A52%3A56-51602485057173158853802835.html
  • 25. Çoban DA, Tan O, Gündoğmuş İ. Clinical and sociodemographic differences in adult women and men with obsessive-compulsive disorder. Psychiatry Behav Sci 2024;14(3):167-175. doi: 10.5455/PBS.20240618101957. https://www.pbsciences.org/fulltext/8-1718705997.pdf?1773829534
  • 26. Dell'Osso B, Benatti B, Hollander E, Fineberg NA, Stein DJ, Lochner C, et al. Socio-demographic and clinical characterization of patients with obsessive-compulsive tic-related disorder (OCTD): an Italian multicenter study. J Psychopathol 2018;24(3):148-53. https://arts.units.it/retrieve/e2913fdd-17a4-f688-e053-3705fe0a67e0/Dell%27Osso%20J%20Psychopathol%202018%20OCTD.pdf
  • 27. Benatti B, Ferrari S, Grancini B, Girone N, Briguglio M, Marazziti D, et al. Suicidal ideation and suicidal attempts in patients with obsessive-compulsive tic-related disorder vs obsessive-compulsive disorder: results of a multicenter Italian study. CNS Spectr 2021;26(4):354-61. doi: 10.1017/S1092852920001157. https://www.cambridge.org/core/journals/cns-spectrums/article/suicidal-ideation-and-suicidal-attempts-in-patients-with-obsessivecompulsive-ticrelated-disorder-vs-obsessivecompulsive-disorder-results-of-a-multicenter-italian-study/B3511C8CD019EFFCCFD83D23C7405ACD
  • 28. Pérez-Vigil A, Fernández de la Cruz L, Brander G, Isomura K, Jangmo A, Feldman I, et al. Association of obsessive-compulsive disorder with objective indicators of educational attainment: a nationwide register-based sibling control study. JAMA Psychiatry 2018;75(1):47-55. doi: 10.1001/jamapsychiatry.2017.3523. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2661815
  • 29. Çoban DA, Tan O. The predictors of occupational disability in obsessive-compulsive disorder in a large clinical sample. Ann Med Res 2019;29(7):1320-5. doi: 10.5455/annalsmedres.2019.05.262. https://pubmed.ncbi.nlm.nih.gov/18063040/
  • 30. Pérez-Vigil A, Fernández de la Cruz L, Brander G, Isomura K, Jangmo A, Kuja-Halkola R, et al. Association of Tourette syndrome and chronic tic disorders with objective indicators of educational attainment: a population-based sibling comparison study. JAMA Neurol 2018;75(9):1098-105. doi: 10.1001/jamaneurol.2018.1194. https://jamanetwork.com/journals/jamaneurology/fullarticle/2681441
  • 31. Isaacs DA, Riordan HR, Claassen DO. Clinical correlates of health-related quality of life in adults with chronic tic disorder. Front Psychiatry 2021;12:619854. doi: 10.3389/fpsyt.2021.619854. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.619854/full

Tik bozukluğuyla komorbid obsesif kompulsif bozukluğu olan erişkinlerde alkol, madde ve nikotin kullanımı

Yıl 2026, Cilt: 13 Sayı: 1 , 25 - 29 , 31.03.2026
https://doi.org/10.32739/jnbs.13.1.285
https://izlik.org/JA77RB74PC

Öz

Obsesif kompulsif bozukluğa (OKB) eşlik eden tik bozukluğunun (TB) sigara kullanımı, alkol kullanım bozukluğu (AKB) ve madde kullanım bozukluğu (MKB) üzerindeki etkisini inceleyen çalışma sayısı sınırlıdır. Bu kesitsel gözlemsel çalışmada, tik bozukluğu olan ya da olmayan toplam 559 OKB tanılı yetişkinde sigara kullanımı ve AKB/MKB sıklığını araştırdık. Ek olarak eğitim düzeyi, işsizlik, evlilik durumu ve intihar girişimi öyküsü gibi yetişkinlik yaşamına ilişkin parametreleri sorguladık. Katılımcıların 54’ünde (%9,66) çalışma sırasında ya da geçmişte TB mevcuttu. TB olan ve olmayan bireyler AKB/MKB ve sigara kullanımı sıklığı ile OKB, anksiyete ve depresyon belirtilerinin şiddeti açısından benzerdi. OKB+TB grubunda OKB daha erken başlangıçlıydı, ayrıca erkek baskınlığı ve düşük evlilik prevalansı dikkat çekiyordu. Eğitim düzeyi, işsizlik oranı ve intihar girişimi öyküsü açısından anlamlı bir fark bulunmadı. Erişkin OKB hastalarında TB komorbiditesi OKB şiddetini, zararlı madde kullanımına yatkınlığı, eğitim düzeyini, işsizlik oranını veya intihar girişimi öyküsünü artırmamaktadır. Ancak evlilik durumu üzerinde anlamlı bir etkisi bulunmaktadır.

Kaynakça

  • 1. Kloft L, Steinel T, Kathmann N. Systematic review of co-occurring OCD and TD: Evidence for a tic-related OCD subtype? Neurosci Biobehav Rev 2018;95:280-314. doi: 10.1016/j.neubiorev.2018.09.021. https://www.sciencedirect.com/science/article/pii/S0149763417309740?via%3Dihub
  • 2. Eddy CM, Cavanna AE. Tourette syndrome and obsessive-compulsive disorder: Compulsivity along the continuum. J Obsessive Compuls Relat Disord 2014;3:363-71. doi:org/10.1016/j.jocrd.2014.04.003 https://www.sciencedirect.com/science/article/pii/S221136491400027X
  • 3. Virtanen S, Sidorchuk A, Fernández de la Cruz L, Brander G, Lichtenstein P, Latvala A, Mataix-Cols D. Association of Tourette syndrome and chronic tic disorder with subsequent risk of alcohol- or drug-related disorders, criminal convictions, and death: A population-based family study. Biol Psychiatry 2021;89(4):407-14. doi: 10.1016/j.biopsych.2020.09.014. https://www.sciencedirect.com/science/article/pii/S0006322320319223?via%3Dihub
  • 4. Cuzen NL, Stein DJ, Lochner C, Fineberg NA. Comorbidity of obsessive-compulsive disorder and substance use disorder: A new heuristic. Hum Psychopharmacol 2014;29:89–93. doi: 10.1002/hup.2373. https://onlinelibrary.wiley.com/doi/10.1002/hup.2373
  • 5. Tan, O. Is obsessive–Compulsive disorder preventive against addiction? JNBS 2021;8:251-61. doi: 10.4103/jnbs.jnbs_15_21 https://journals.lww.com/jons/Fulltext/2021/08030/Is_Obsessive_Compulsive_Disorder_Preventive.10.aspx
  • 6. Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, et al. The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 1989;28(4):566-73. doi: 10.1097/00004583-198907000-00015. https://www.sciencedirect.com/science/article/abs/pii/S0890856709654770?via%3Dihub
  • 7. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989;46(11):1006-11. doi: 10.1001/archpsyc.1989.01810110048007. https://jamanetwork.com/journals/jamapsychiatry/article-abstract/494743
  • 8. Williams JB. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988;45(8):742-7. doi: 10.1001/archpsyc.1988.01800320058007. https://jamanetwork.com/journals/jamapsychiatry/article-abstract/494356
  • 9. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 1988;56(6):893-7. doi: 10.1037//0022-006x.56.6.893. https://psycnet.apa.org/record/1989-10559-001
  • 10. Comings DE. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. I. Drug abuse. Drug Alcohol Depend 1994;35(1):1-16. doi: 10.1016/0376-8716(94)90104-x. https://www.sciencedirect.com/science/article/abs/pii/037687169490104X?via%3Dihub
  • 11. Comings DE. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. II. Alcohol abuse. Drug Alcohol Depend 1994;35(1):17-24. doi: 10.1016/0376-8716(94)90105-8. https://www.sciencedirect.com/science/article/abs/pii/037687169490104X?via%3Dihub
  • 12. Coffey BJ, Miguel EC, Biederman J, Baer L, Rauch SL, O'Sullivan RL, et al. Tourette's disorder with and without obsessive-compulsive disorder in adults: are they different? J Nerv Ment Dis 1988;186(4):201-16. doi: 10.1097/00005053-199804000-00001. https://journals.lww.com/jonmd/abstract/1998/04000/tourette_s_disorder_with_and_without.1.aspx
  • 13. Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA, Illmann C, et al. Tourette Syndrome Association International Consortium for Genetics. Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome. JAMA Psychiatry 2015;72(4):325-33. doi: 10.1001/jamapsychiatry.2014.2650. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2110028
  • 14. Andersen K, Groth C, Skov L, Debes NM. Childhood comorbidity severity impacts adolescent substance consumption in patients with Tourette syndrome. Pediatr Neurol 2023;145:88-93. doi: 10.1016/j.pediatrneurol.2023.05.004. https://www.sciencedirect.com/science/article/pii/S0887899423001479?via%3Dihub
  • 15. Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: Prevalence, phenomenology, comorbidities, and coexistent psychopathologies. Lancet Psychiatry 2015;2(1):68-87. doi: 10.1016/S2215-0366(14)00132-1. https://www.sciencedirect.com/science/article/abs/pii/S2215036614001321?via%3Dihub
  • 16. Garris J, Quigg M. The female Tourette patient: Sex differences in Tourette disorder. Neurosci Biobehav Rev 2021;129:261-268. doi: 10.1016/j.neubiorev.2021.08.001. https://www.sciencedirect.com/science/article/pii/S0149763421003432?via%3Dihub https://www.neurology.org/doi/10.1212/WNL.0000000000210249
  • 17. Dy-Hollins ME, Chibnik LB, Tracy NA, Osiecki L, Budman CL, Cath DC, et al. Sex differences in natural history and health outcomes among individuals with tic disorders. Neurology 2025;104(3):e210249. doi: 10.1212/WNL.0000000000210249.https://onlinelibrary.wiley.com/doi/10.1111/ene.70252
  • 18. Subramaniam M, Soh P, Vaingankar JA, Picco L, Chong SA. Quality of life in obsessive-compulsive disorder: Impact of the disorder and of treatment. CNS Drugs 2013;27(5):367-383. doi: 10.1007/s40263-013-0056-z.https://link.springer.com/article/10.1007/s40263-013-0056-z
  • 19. O'Hare D, Helmes E, Eapen V, Grove R, McBain K, Reece J. The impact of tic severity, comorbidity and peer attachment on quality of life outcomes and functioning in Tourette's syndrome: Parental perspectives. Child Psychiatry Hum Dev 2016;47(4):563-573. doi: 10.1007/s10578-015-0590-7. https://link.springer.com/article/10.1007/s10578-015-0590-7
  • 20. Pring K, Malli M, Hardy BW, Rapp SR, Storch EA, et al. Reframing stigma in Tourette syndrome: An updated scoping review. Eur Child Adolesc Psychiatry 2025;34(1):19-39. doi: 10.1007/s00787-023-02332-3. https://link.springer.com/article/10.1007/s00787-023-02332-3
  • 21. Feehan A, Colozzo P, Pritchard L, Smith V, Charest M. Communication and psychosocial functioning in children with Tourette syndrome: Parent-reported measures. Int J Lang Commun Disord 2025;60(4):e70056. doi: 10.1111/1460-6984.70056. https://onlinelibrary.wiley.com/doi/full/10.1111/1460-6984.70056
  • 22. Martindale JM, Chapman L, Carson AJ, Reilly K, Malli M, Storch EA, et al. Beyond the tics: Experiences of stigma and psychosocial impact in Tourette syndrome. Child Psychiatry Hum Dev 2026. doi: 10.1007/s10578-026-01965-0.https://link.springer.com/article/10.1007/s10578-026-01965-0
  • 23. United Nations, Department of Economic and Social Affairs, Population Division. World Marriage Data 2019. Available at: https://www.un.org/development/desa/pd/data/world-marriage-data
  • 24. Turkish Statistical Institute (TÜİK). Marriage Statistics. Available at: https://web.archive.org/web/20150721230539/http://rapory.tuik.gov.tr/19-07-2015-20%3A52%3A56-51602485057173158853802835.html
  • 25. Çoban DA, Tan O, Gündoğmuş İ. Clinical and sociodemographic differences in adult women and men with obsessive-compulsive disorder. Psychiatry Behav Sci 2024;14(3):167-175. doi: 10.5455/PBS.20240618101957. https://www.pbsciences.org/fulltext/8-1718705997.pdf?1773829534
  • 26. Dell'Osso B, Benatti B, Hollander E, Fineberg NA, Stein DJ, Lochner C, et al. Socio-demographic and clinical characterization of patients with obsessive-compulsive tic-related disorder (OCTD): an Italian multicenter study. J Psychopathol 2018;24(3):148-53. https://arts.units.it/retrieve/e2913fdd-17a4-f688-e053-3705fe0a67e0/Dell%27Osso%20J%20Psychopathol%202018%20OCTD.pdf
  • 27. Benatti B, Ferrari S, Grancini B, Girone N, Briguglio M, Marazziti D, et al. Suicidal ideation and suicidal attempts in patients with obsessive-compulsive tic-related disorder vs obsessive-compulsive disorder: results of a multicenter Italian study. CNS Spectr 2021;26(4):354-61. doi: 10.1017/S1092852920001157. https://www.cambridge.org/core/journals/cns-spectrums/article/suicidal-ideation-and-suicidal-attempts-in-patients-with-obsessivecompulsive-ticrelated-disorder-vs-obsessivecompulsive-disorder-results-of-a-multicenter-italian-study/B3511C8CD019EFFCCFD83D23C7405ACD
  • 28. Pérez-Vigil A, Fernández de la Cruz L, Brander G, Isomura K, Jangmo A, Feldman I, et al. Association of obsessive-compulsive disorder with objective indicators of educational attainment: a nationwide register-based sibling control study. JAMA Psychiatry 2018;75(1):47-55. doi: 10.1001/jamapsychiatry.2017.3523. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2661815
  • 29. Çoban DA, Tan O. The predictors of occupational disability in obsessive-compulsive disorder in a large clinical sample. Ann Med Res 2019;29(7):1320-5. doi: 10.5455/annalsmedres.2019.05.262. https://pubmed.ncbi.nlm.nih.gov/18063040/
  • 30. Pérez-Vigil A, Fernández de la Cruz L, Brander G, Isomura K, Jangmo A, Kuja-Halkola R, et al. Association of Tourette syndrome and chronic tic disorders with objective indicators of educational attainment: a population-based sibling comparison study. JAMA Neurol 2018;75(9):1098-105. doi: 10.1001/jamaneurol.2018.1194. https://jamanetwork.com/journals/jamaneurology/fullarticle/2681441
  • 31. Isaacs DA, Riordan HR, Claassen DO. Clinical correlates of health-related quality of life in adults with chronic tic disorder. Front Psychiatry 2021;12:619854. doi: 10.3389/fpsyt.2021.619854. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.619854/full
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Psikiyatri
Bölüm Klinik Araştırma
Yazarlar

Oğuz Tan 0000-0002-8056-6244

Deniz Adnan Çoban 0000-0001-9197-2240

Gönderilme Tarihi 3 Temmuz 2025
Kabul Tarihi 23 Mart 2026
Yayımlanma Tarihi 31 Mart 2026
DOI https://doi.org/10.32739/jnbs.13.1.285
IZ https://izlik.org/JA77RB74PC
Yayımlandığı Sayı Yıl 2026 Cilt: 13 Sayı: 1

Kaynak Göster

Vancouver 1.Oğuz Tan, Deniz Adnan Çoban. Alcohol, Substance and Nicotine Use in Adults having Obsessive-Compulsive Disorder Comorbid with Tic Disorder. JNBS. 01 Mart 2026;13(1):25-9. doi:10.32739/jnbs.13.1.285