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Enteral Beslenen Hastalarda İki Farklı Ağız Bakım Yöntemine Göre Pnömoni Oranlarının Karşılaştırılması: Akut İnmeli Hastalarda Pilot Çalışma

Yıl 2025,
https://doi.org/10.17049/jnursology.1510606

Öz

Amaç: Bu çalışma, inme sonrası nazogastrik tüp ile beslenen ve ağızdan gıda alımı olmayan hastalarda iki farklı ağız bakım yönteminin inme ile ilişkili pnömoni insidansı üzerindeki etkisini karşılaştırmıştır.

Yöntemler: Randomize kontrollü olarak planlanan bu çalışma Ağustos 2020 ile Nisan 2021 arasında Ege Üniversitesi Hastanesi Nöroloji Yoğun Bakım Ünitesinde yürütüldü. Her iki gruba yedi gün boyunca farklı ağız bakım protokolleri uygulandı. Verilerin toplanmasında, Hasta Bilgi Formu, Ulusal Sağlık Enstitüleri İnme Ölçeği, Glasgow Koma Ölçeği, Yatak Başı Ağız Değerlendirme İzlem Formu ve Hasta Takip Formu kullanıldı. Uygulama ve kontrol gruplarına yedi gün boyunca ağız bakımı uygulandı, ağız sağlıkları ve tükürük pH'ı ölçülüp kaydedildi. Pnömoni tanısı fizik muayene, kan testleri ve göğüs röntgenine dayanarak enfeksiyon hastalıkları birimi tarafından konuldu.

Bulgular: Hastaların 7 günlük ağız sağlığı değerlendirme puanlarına göre uygulama ve kontrol grubu arasındaki farkın anlamlı olduğu tespit edildi (P<,05). Uygulama grubunda hiçbir hastada pnömoni gelişmezken kontrol grubundaki hastaların %25'inde pnömoni gelişti, gruplar arasındaki fark anlamız bulundu (P<,05). Pnömoni gelişen ve gelişmeyen hastaların ağız sağlık değerlendirme puanları arasındaki farkın anlamlı olduğu belirlendi (P<,05).

Sonuç: Kapsamlı ağız bakım uygulamasının ağız sağlığı üzerinde anlamlı etkisi olduğu ancak tükürük pH'ını ve pnömoni oranlarını etkilenmediği belirlenmiştir.

Kaynakça

  • 1. GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):439-458. https://doi.org/10.1016/S1474-4422(19)30034-1
  • 2. Ulusal Hastalık Yükü Çalışması Sonuçları ve Çözümleri 9: Beyin Damar Hastalıkları ve Demans (2017). Accessed December 21, 2023. http://www.tip.hacettepe.edu.tr/ekler/pdf
  • 3. Türkiye İstatistik Kurumu. Accessed October 20, 2023. https://www.tuik.gov.tr
  • 4. Westendorp WF, Nederkoorn PJ, Vermeij JD, Dijkgraaf MG, van de Beek D. Post-stroke infection: a systematic review and meta-analysis. BMC Neurol. 2011;11:110. Published 2011 Sep 20. https://doi.org/10.1186/1471-2377-11-110
  • 5. Kishore AK, Vail A, Chamorro A, et al. How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis. Stroke. 2015;46(5):1202-1209. https://doi.org/10.1161/STROKEAHA.114.007843
  • 6. Krishnamurthy R, Balasubramanium RK, Premkumar PK. Systematic Review and Meta-Analysis of Dysphagia and Associated Pneumonia in Patients With Stroke From India: A Call to Arms. Am J Speech Lang Pathol. 2022;31(1):502-514. https://doi.org/10.1044/2021_AJSLP-21-00175
  • 7. Scherbakov N, von Haehling S, Anker SD, Dirnagl U, Doehner W. Stroke induced Sarcopenia: muscle wasting and disability after stroke. Int J Cardiol. 2013;170(2):89-94. https://doi.org/10.1016/j.ijcard.2013.10.031
  • 8. Burgos R, Bretón I, Cereda E, et al. ESPEN guideline clinical nutrition in neurology. Clin Nutr. 2018;37(1):354-396. https://doi.org/10.1016/j.clnu.2017.09.003
  • 9. Brogan E, Langdon C, Brookes K, Budgeon C, Blacker D. Respiratory infections in acute stroke: nasogastric tubes and immobility are stronger predictors than dysphagia. Dysphagia. 2014;29(3):340-345. https://doi.org/10.1007/s00455-013-9514-5
  • 10. Dziewas R, Ritter M, Schilling M, et al. Pneumonia in acute stroke patients fed by nasogastric tube. J Neurol Neurosurg Psychiatry. 2004;75(6):852-856. https://doi.org/10.1136/jnnp.2003.019075
  • 11. Schwarz M, Coccetti A, Murdoch A, Cardell E. The impact of aspiration pneumonia and nasogastric feeding on clinical outcomes in stroke patients: A retrospective cohort study. J Clin Nurs. 2018;27(1-2):e235-e241. https://doi.org/10.1111/jocn.13922
  • 12. Arnold M, Liesirova K, Broeg-Morvay A, et al. Dysphagia in Acute Stroke: Incidence, Burden and Impact on Clinical Outcome. PLoS One. 2016;11(2):e0148424. https://doi.org/10.1371/journal.pone.0148424
  • 13. Brogan E, Langdon C, Brookes K, Budgeon C, Blacker D. Can't swallow, can't transfer, can't toilet: factors predicting infections in the first week post stroke. J Clin Neurosci. 2015;22(1):92-97. https://doi.org/10.1016/j.jocn.2014.05.035
  • 14. Kalra L, Hodsoll J, Irshad S, Smithard D, Manawadu D; STROKE-INF Investigators. Association between nasogastric tubes, pneumonia, and clinical outcomes in acute stroke patients. Neurology. 2016;87(13):1352-1359. https://doi.org/10.1212/WNL.0000000000003151
  • 15. Cieplik F, Wiedenhofer AM, Pietsch V, et al. Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia-A Prospective Observational Study. Front Neurol. 2020;11:528056. https://doi.org/10.3389/fneur.2020.528056
  • 16. Sørensen RT, Rasmussen RS, Overgaard K, Lerche A, Johansen AM, Lindhardt T. Dysphagia screening and intensified oral hygiene reduce pneumonia after stroke. J Neurosci Nurs. 2013;45(3):139-146. https://doi.org/10.1097/JNN.0b013e31828a412c
  • 17. Maeda K, Akagi J. Oral care may reduce pneumonia in the tube-fed elderly: a preliminary study. Dysphagia. 2014;29(5):616-621. doi:10.1007/s00455-014-9553-6
  • 18. Lyons M, Smith C, Boaden E, et al. Oral care after stroke: Where are we now? Eur Stroke J. 2018;3(4):347-354. https://doi.org/10.1177/2396987318775206
  • 19. Ab Malik N, Mohamad Yatim S, Abdul Razak F, et al. A multi‐centre randomised clinical trial of oral hygiene interventions following stroke—A 6‐month trial. J Oral Rehabil. 2018;45(2):132-139. https://doi.org/10.1111/joor.12582
  • 20. Oliveira IdJ, Couto GR, Santos RV, et al. Best practice recommendations for dysphagia management in stroke patients: a consensus from a Portuguese expert panel. Port J Public Health. 2022;39(3):145-162. https://doi.org/10.1159/000520505
  • 21. Cadilhac DA, Dalli LL, Morrison JL, et al. The Australian stroke clinical registry annual report 2021. https://research.monash.edu/en/publications/the-australian-stroke-clinical-registry-annual-report-2021
  • 22. Lam OL, McMillan AS, Samaranayake LP, Li LS, McGrath C. Randomized clinical trial of oral health promotion interventions among patients following stroke. Arch Phys Med Rehabil. 2013;94(3):435-443. https://doi.org/10.1016/j.apmr.2012.10.024
  • 23. Dai R, Lam OLT, Lo ECM, Li LSW, McGrath C. A randomized clinical trial of oral hygiene care programmes during stroke rehabilitation. J Dent. 2017;61:48-54. https://doi.org/10.1016/j.jdent.2017.04.001
  • 24. Campbell P, Bain B, Furlanetto DL, Brady MC. Interventions for improving oral health in people after stroke. Cochrane Database Syst Rev. 2020;12(12):CD003864. https://doi.org/10.1002/14651858.cd003864.pub3
  • 25. Umay E, Eyigor S, Ertekin C, et al. Best practice recommendations for stroke patients with dysphagia: a Delphi-based consensus study of experts in Turkey-part II: rehabilitation. Dysphagia, 2021: p. https://doi.org/10.1007/s00455-020-10218-8
  • 26. Remijn L, Sanchez F, Heijnen BJ, Windsor C, Speyer R. Effects of oral health interventions in people with oropharyngeal dysphagia: a systematic review. J Clin Med. 2022;11(12):3521. https://doi.org/10.3390/jcm11123521
  • 27. Soldani FA, Lamont T, Jones K, et al. One‐to‐one oral hygiene advice provided in a dental setting for oral health. Cochrane Database Syst Rev. 2018;10(10):CD007447. https://doi.org/10.1002/14651858.cd007447.pub2
  • 28. van der Maarel‐Wierink, CD, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C. Oral health care and aspiration pneumonia in frail older people: a systematic literature review. Gerodontology. 2013;30(1):3-9. https://doi.org/10.1111/j.1741-2358.2012.00637.x
  • 29. Cardoso AF, Ribeiro LE, Santos T, et al. Oral hygiene in patients with stroke: a best practice implementation project protocol. Nurs Rep. 2023;13(1):148-156. https://doi.org/10.3390/nursrep13010016
  • 30. Chen H-J, Chen J-L, Chen C-Y, Lee M, Chang W-H, Huang T-T. Effect of an oral health programme on oral health, oral intake, and nutrition in patients with stroke and dysphagia in Taiwan: A randomised controlled trial. Int J Environ Res Public Health. 2019;16(12):2228. https://doi.org/10.3390/ijerph16122228
  • 31. Shiraisi A., Yoshimura Y, Wakabayashi H, Nagano F, Bise T, Shimazu S, Improvement in oral health enhances the recovery of activities of daily living and dysphagia after stroke. J Stroke Cerebrovasc Dis. 2021;30(9):105961. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105961
  • 32. Aoyagi M, Furuya J, Matsubara C, et al. Association between improvement of oral health, swallowing function, and nutritional intake method in acute stroke patients. Int J Environ Res Public Health. 2021;18(21):11379. https://doi.org/10.3390/ijerph182111379
  • 33. Baliga S, Muglikar S, Kale R. Salivary pH: A diagnostic biomarker. J Indian Soc Periodontol. 2013;17(4):461-465. https://doi.org/10.4103/0972-124X.118317
  • 34. Langdon PC, Lee AH, Binns CW. High incidence of respiratory infections in 'nil by mouth' tube-fed acute ischemic stroke patients. Neuroepidemiology. 2009;32(2):107-113. https://doi.org/10.1159/000177036
  • 35. Cichero JA, Steele C, Duivestein J, et al. The Need for International Terminology and Definitions for Texture-Modified Foods and Thickened Liquids Used in Dysphagia Management: Foundations of a Global Initiative. Curr Phys Med Rehabil Rep. 2013;1(4):280-291. https://doi.org/10.1007/s40141-013-0024-z
  • 36. Wagner C, Marchina S, Deveau JA, Frayne C, Sulmonte K, Kumar S. Risk of Stroke-Associated Pneumonia and Oral Hygiene. Cerebrovasc Dis. 2016;41(1-2):35-39. https://doi.org/10.1159/000440733
  • 37. Murray J, Scholten I. An oral hygiene protocol improves oral health for patients in inpatient stroke rehabilitation. Gerodontology. 2018;35(1):18-24. https://doi.org/10.1111/ger.12309
  • 38. Wang ZY, Chen JM, Ni GX. Effect of an indwelling nasogastric tube on swallowing function in elderly post-stroke dysphagia patients with long-term nasal feeding. BMC Neurol. 2019;19(1):83. https://doi.org/10.1186/s12883-019-1314-6

Investigation of Pneumonia Rates in Enteral Fed Patients with Two Different Oral Care Methods: Pilot Study in Patients with Acute Stroke

Yıl 2025,
https://doi.org/10.17049/jnursology.1510606

Öz

Objective: This study compared the impact of two different oral care methods on the incidence of stroke-associated pneumonia in patients who were fed via nasogastric tube and had no oral intake after a stroke.

Methods: This randomized controlled trial was conducted at the Neurology Intensive Care Unit of Ege University Hospital between August 2020 and April 2021. Different oral care protocols were administered to both groups for seven days. Data were collected using the Patient Information Form, the National Institutes of Health Stroke Scale, the Glasgow Coma Scale, the Bedside Oral Exam and Patient Follow-up Form. Oral care was applied to both the intervention and control groups for seven days, with oral health and saliva pH measured and recorded. The diagnosis of pneumonia was made by the Infectious Diseases unit based on physical examination, blood tests, and chest X-rays.

Results: The difference in the seven-day oral health assessment scores between the intervention and control groups was found to be significant (P<.05). While no patients in the intervention group developed pneumonia, 25% of patients in the control group did, with the difference between the groups found to be insignificant (P<.05). The difference in oral health assessment scores between patients who developed pneumonia and those who did not was found to be significant (P<.05).

Conclusion: It was determined that comprehensive oral care had a significant effect on oral health but did not affect saliva pH or pneumonia rates.

Kaynakça

  • 1. GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):439-458. https://doi.org/10.1016/S1474-4422(19)30034-1
  • 2. Ulusal Hastalık Yükü Çalışması Sonuçları ve Çözümleri 9: Beyin Damar Hastalıkları ve Demans (2017). Accessed December 21, 2023. http://www.tip.hacettepe.edu.tr/ekler/pdf
  • 3. Türkiye İstatistik Kurumu. Accessed October 20, 2023. https://www.tuik.gov.tr
  • 4. Westendorp WF, Nederkoorn PJ, Vermeij JD, Dijkgraaf MG, van de Beek D. Post-stroke infection: a systematic review and meta-analysis. BMC Neurol. 2011;11:110. Published 2011 Sep 20. https://doi.org/10.1186/1471-2377-11-110
  • 5. Kishore AK, Vail A, Chamorro A, et al. How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis. Stroke. 2015;46(5):1202-1209. https://doi.org/10.1161/STROKEAHA.114.007843
  • 6. Krishnamurthy R, Balasubramanium RK, Premkumar PK. Systematic Review and Meta-Analysis of Dysphagia and Associated Pneumonia in Patients With Stroke From India: A Call to Arms. Am J Speech Lang Pathol. 2022;31(1):502-514. https://doi.org/10.1044/2021_AJSLP-21-00175
  • 7. Scherbakov N, von Haehling S, Anker SD, Dirnagl U, Doehner W. Stroke induced Sarcopenia: muscle wasting and disability after stroke. Int J Cardiol. 2013;170(2):89-94. https://doi.org/10.1016/j.ijcard.2013.10.031
  • 8. Burgos R, Bretón I, Cereda E, et al. ESPEN guideline clinical nutrition in neurology. Clin Nutr. 2018;37(1):354-396. https://doi.org/10.1016/j.clnu.2017.09.003
  • 9. Brogan E, Langdon C, Brookes K, Budgeon C, Blacker D. Respiratory infections in acute stroke: nasogastric tubes and immobility are stronger predictors than dysphagia. Dysphagia. 2014;29(3):340-345. https://doi.org/10.1007/s00455-013-9514-5
  • 10. Dziewas R, Ritter M, Schilling M, et al. Pneumonia in acute stroke patients fed by nasogastric tube. J Neurol Neurosurg Psychiatry. 2004;75(6):852-856. https://doi.org/10.1136/jnnp.2003.019075
  • 11. Schwarz M, Coccetti A, Murdoch A, Cardell E. The impact of aspiration pneumonia and nasogastric feeding on clinical outcomes in stroke patients: A retrospective cohort study. J Clin Nurs. 2018;27(1-2):e235-e241. https://doi.org/10.1111/jocn.13922
  • 12. Arnold M, Liesirova K, Broeg-Morvay A, et al. Dysphagia in Acute Stroke: Incidence, Burden and Impact on Clinical Outcome. PLoS One. 2016;11(2):e0148424. https://doi.org/10.1371/journal.pone.0148424
  • 13. Brogan E, Langdon C, Brookes K, Budgeon C, Blacker D. Can't swallow, can't transfer, can't toilet: factors predicting infections in the first week post stroke. J Clin Neurosci. 2015;22(1):92-97. https://doi.org/10.1016/j.jocn.2014.05.035
  • 14. Kalra L, Hodsoll J, Irshad S, Smithard D, Manawadu D; STROKE-INF Investigators. Association between nasogastric tubes, pneumonia, and clinical outcomes in acute stroke patients. Neurology. 2016;87(13):1352-1359. https://doi.org/10.1212/WNL.0000000000003151
  • 15. Cieplik F, Wiedenhofer AM, Pietsch V, et al. Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia-A Prospective Observational Study. Front Neurol. 2020;11:528056. https://doi.org/10.3389/fneur.2020.528056
  • 16. Sørensen RT, Rasmussen RS, Overgaard K, Lerche A, Johansen AM, Lindhardt T. Dysphagia screening and intensified oral hygiene reduce pneumonia after stroke. J Neurosci Nurs. 2013;45(3):139-146. https://doi.org/10.1097/JNN.0b013e31828a412c
  • 17. Maeda K, Akagi J. Oral care may reduce pneumonia in the tube-fed elderly: a preliminary study. Dysphagia. 2014;29(5):616-621. doi:10.1007/s00455-014-9553-6
  • 18. Lyons M, Smith C, Boaden E, et al. Oral care after stroke: Where are we now? Eur Stroke J. 2018;3(4):347-354. https://doi.org/10.1177/2396987318775206
  • 19. Ab Malik N, Mohamad Yatim S, Abdul Razak F, et al. A multi‐centre randomised clinical trial of oral hygiene interventions following stroke—A 6‐month trial. J Oral Rehabil. 2018;45(2):132-139. https://doi.org/10.1111/joor.12582
  • 20. Oliveira IdJ, Couto GR, Santos RV, et al. Best practice recommendations for dysphagia management in stroke patients: a consensus from a Portuguese expert panel. Port J Public Health. 2022;39(3):145-162. https://doi.org/10.1159/000520505
  • 21. Cadilhac DA, Dalli LL, Morrison JL, et al. The Australian stroke clinical registry annual report 2021. https://research.monash.edu/en/publications/the-australian-stroke-clinical-registry-annual-report-2021
  • 22. Lam OL, McMillan AS, Samaranayake LP, Li LS, McGrath C. Randomized clinical trial of oral health promotion interventions among patients following stroke. Arch Phys Med Rehabil. 2013;94(3):435-443. https://doi.org/10.1016/j.apmr.2012.10.024
  • 23. Dai R, Lam OLT, Lo ECM, Li LSW, McGrath C. A randomized clinical trial of oral hygiene care programmes during stroke rehabilitation. J Dent. 2017;61:48-54. https://doi.org/10.1016/j.jdent.2017.04.001
  • 24. Campbell P, Bain B, Furlanetto DL, Brady MC. Interventions for improving oral health in people after stroke. Cochrane Database Syst Rev. 2020;12(12):CD003864. https://doi.org/10.1002/14651858.cd003864.pub3
  • 25. Umay E, Eyigor S, Ertekin C, et al. Best practice recommendations for stroke patients with dysphagia: a Delphi-based consensus study of experts in Turkey-part II: rehabilitation. Dysphagia, 2021: p. https://doi.org/10.1007/s00455-020-10218-8
  • 26. Remijn L, Sanchez F, Heijnen BJ, Windsor C, Speyer R. Effects of oral health interventions in people with oropharyngeal dysphagia: a systematic review. J Clin Med. 2022;11(12):3521. https://doi.org/10.3390/jcm11123521
  • 27. Soldani FA, Lamont T, Jones K, et al. One‐to‐one oral hygiene advice provided in a dental setting for oral health. Cochrane Database Syst Rev. 2018;10(10):CD007447. https://doi.org/10.1002/14651858.cd007447.pub2
  • 28. van der Maarel‐Wierink, CD, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C. Oral health care and aspiration pneumonia in frail older people: a systematic literature review. Gerodontology. 2013;30(1):3-9. https://doi.org/10.1111/j.1741-2358.2012.00637.x
  • 29. Cardoso AF, Ribeiro LE, Santos T, et al. Oral hygiene in patients with stroke: a best practice implementation project protocol. Nurs Rep. 2023;13(1):148-156. https://doi.org/10.3390/nursrep13010016
  • 30. Chen H-J, Chen J-L, Chen C-Y, Lee M, Chang W-H, Huang T-T. Effect of an oral health programme on oral health, oral intake, and nutrition in patients with stroke and dysphagia in Taiwan: A randomised controlled trial. Int J Environ Res Public Health. 2019;16(12):2228. https://doi.org/10.3390/ijerph16122228
  • 31. Shiraisi A., Yoshimura Y, Wakabayashi H, Nagano F, Bise T, Shimazu S, Improvement in oral health enhances the recovery of activities of daily living and dysphagia after stroke. J Stroke Cerebrovasc Dis. 2021;30(9):105961. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105961
  • 32. Aoyagi M, Furuya J, Matsubara C, et al. Association between improvement of oral health, swallowing function, and nutritional intake method in acute stroke patients. Int J Environ Res Public Health. 2021;18(21):11379. https://doi.org/10.3390/ijerph182111379
  • 33. Baliga S, Muglikar S, Kale R. Salivary pH: A diagnostic biomarker. J Indian Soc Periodontol. 2013;17(4):461-465. https://doi.org/10.4103/0972-124X.118317
  • 34. Langdon PC, Lee AH, Binns CW. High incidence of respiratory infections in 'nil by mouth' tube-fed acute ischemic stroke patients. Neuroepidemiology. 2009;32(2):107-113. https://doi.org/10.1159/000177036
  • 35. Cichero JA, Steele C, Duivestein J, et al. The Need for International Terminology and Definitions for Texture-Modified Foods and Thickened Liquids Used in Dysphagia Management: Foundations of a Global Initiative. Curr Phys Med Rehabil Rep. 2013;1(4):280-291. https://doi.org/10.1007/s40141-013-0024-z
  • 36. Wagner C, Marchina S, Deveau JA, Frayne C, Sulmonte K, Kumar S. Risk of Stroke-Associated Pneumonia and Oral Hygiene. Cerebrovasc Dis. 2016;41(1-2):35-39. https://doi.org/10.1159/000440733
  • 37. Murray J, Scholten I. An oral hygiene protocol improves oral health for patients in inpatient stroke rehabilitation. Gerodontology. 2018;35(1):18-24. https://doi.org/10.1111/ger.12309
  • 38. Wang ZY, Chen JM, Ni GX. Effect of an indwelling nasogastric tube on swallowing function in elderly post-stroke dysphagia patients with long-term nasal feeding. BMC Neurol. 2019;19(1):83. https://doi.org/10.1186/s12883-019-1314-6
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hemşirelik Esasları, Yoğun Bakım Hemşireliği
Bölüm Araştırma Makaleleri
Yazarlar

Alev Yıldız Ilıman 0000-0001-7957-8873

İsmet Eşer 0000-0002-6563-6822

Hadiye Şirin 0000-0003-0262-3706

Erken Görünüm Tarihi 30 Eylül 2025
Yayımlanma Tarihi 5 Ekim 2025
Gönderilme Tarihi 4 Temmuz 2024
Kabul Tarihi 18 Nisan 2025
Yayımlandığı Sayı Yıl 2025

Kaynak Göster

AMA Yıldız Ilıman A, Eşer İ, Şirin H. Investigation of Pneumonia Rates in Enteral Fed Patients with Two Different Oral Care Methods: Pilot Study in Patients with Acute Stroke. Journal of Nursology. Published online 01 Eylül 2025. doi:10.17049/jnursology.1510606

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