Mikrobiata ve Kronik Hastalıklar

Yıl 2017, Cilt: 3 Sayı: 3, 126 - 136, 28.09.2017

Hasret Cengiz Ceyhun Varım Ali Tamer

Öz

Vücudumuzda
mikrobiata adı verilen çok sayıda kommensal ve mutual mikroorganizma mevcuttur.
Kendi mikrobial florası olan başlıca sistemler gastrointestinal sistem, genitoüriner
sistem ve solunum sistemi ve deridir. Özellikle barsak mikrobiata denilen
gastrointestinal sistem florasının, son zamanlarda bir çok fizyolojik ve
patolojik süreçte önemi fark edilmiştir.

Barsak
mikrobatası ile ilgili ilk çalışmalar rekürren C. Difficile enfeksiyonunun
tedavisi için planlanmıştır. Barsak mikrobiota modulasyonu ile rekürren C.
Difficile enfeksiyonunun tedavisinde sağlanan büyük başarı ile birlikte barsak
mikrobatası birçok gastrointestinal ve extragastrointestinal kronik hastalıkta
çalışılmış ve önemi anlaşılmıştır.Bu yüzden şu anda barsak mikrobata
modulasyonu ve değişimi ile bir çok hastalık tedavi edilmeye çalışılmaktadır.

İntestinal
mikrobiota gelecekte birçok kronik hastalığın tedavisinde büyük umut vaad etmektedir.
Ancak daha kapsamlı çalışmalara ciddiyetle ihtiyaç vardır. Biz bu derlemede
çeşitli kronik hastalıklar ile intestinal mikrobiata arasındaki ilişkiyi inceledik.

Anahtar Kelimeler

kronik hastalık, mikrobiata, barsak florası

Kaynakça

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